Doxorubicin—An Agent with Multiple Mechanisms of Anticancer Activity

Cells, Год журнала: 2023, Номер 12(4), С. 659 - 659

Опубликована: Фев. 19, 2023

Doxorubicin (DOX) constitutes the major constituent of anti-cancer treatment regimens currently in clinical use. However, precise mechanisms DOX’s action are not fully understood. Emerging evidence points to pleiotropic anticancer activity DOX, including its contribution DNA damage, reactive oxygen species (ROS) production, apoptosis, senescence, autophagy, ferroptosis, and pyroptosis induction, as well immunomodulatory role. This review aims collect information on DOX influence anti-tumor immune response, providing a rationale behind importance modern cancer therapy.

Язык: Английский

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Single-cell analysis highlights differences in druggable pathways underlying adaptive or fibrotic kidney regeneration

Nature Communications, Год журнала: 2022, Номер 13(1)

Опубликована: Июль 11, 2022

The kidney has tremendous capacity to repair after acute injury, however, pathways guiding adaptive and fibrotic are poorly understood. We developed a model of regeneration by titrating ischemic injury dose. performed detailed biochemical histological analysis profiled transcriptomic changes at bulk single-cell level (> 110,000 cells) over time. Our highlights proximal tubule cells as key susceptible injury. Adaptive correlated with fatty acid oxidation oxidative phosphorylation. identify specific maladaptive/profibrotic cluster long ischemia, which expresses proinflammatory profibrotic cytokines myeloid cell chemotactic factors. Druggability pyroptosis/ferroptosis vulnerable in these cells. Pharmacological targeting vivo pushed towards ameliorates fibrosis. In summary, our defines differences identifies druggable for pharmacological intervention prevent

Язык: Английский

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VB12-Sericin-PBLG-IR780 Nanomicelles for Programming Cell Pyroptosis via Photothermal (PTT)/Photodynamic (PDT) Effect-Induced Mitochondrial DNA (mitoDNA) Oxidative Damage

ACS Applied Materials & Interfaces, Год журнала: 2022, Номер 14(15), С. 17008 - 17021

Опубликована: Апрель 8, 2022

Pyroptosis, a kind of programmed cell death involving inflammation, might be powerful way to fight against tumors, for example, using immunotherapy. However, how trigger pyroptosis in cancer cells is an important issue. Photothermal (PTT)/photodynamic (PDT) therapy crucial strategy inducing with noninvasiveness. In this work, sericin derivative modified poly(γ-benzyl-l-glutamate) (PBLG) could self-assemble and was stable aqueous environment. Furthermore, the conjugated tumor-targeting agent VB12 loaded IR780. Finally, we successfully synthesized VB12-sericin-PBLG-IR780 nanomicelles. The as-designed nanomicelles showed appropriate particle sizes, spherical morphology, improved photothermal stability, high conversion efficiency (∼40%), which generated reactive oxygen species (ROS) simultaneously. Through enhanced cellular uptake, deliver more IR780 into cells. With near-infrared (NIR), significantly inhibit expression ATP synthase, called ATP5MC3, followed by mitochondrial damage. presence (mitoROS) led oxidative damage DNA (mitoDNA), further activates NLRP3/Caspase-1/gasdermin D (GSDMD)-dependent promote dendritic (DC) maturation pyroptosis. our data that achieve brilliant antitumor effect activate DC maturation, initiate T-cell recruiting, prime adaptive efficiency. Overall, well-prepared offer tumor-targeted approach immunity via PTT/PDT effect-induced mitoDNA

Язык: Английский

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Nobiletin as an inducer of programmed cell death in cancer: a review

APOPTOSIS, Год журнала: 2022, Номер 27(5-6), С. 297 - 310

Опубликована: Март 21, 2022

Язык: Английский

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Role of pyroptosis in the pathogenesis and treatment of diseases

MedComm, Год журнала: 2023, Номер 4(3)

Опубликована: Апрель 25, 2023

Abstract Programmed cell death (PCD) is regarded as a pathological form of with an intracellular program mediated, which plays pivotal role in maintaining homeostasis and embryonic development. Pyroptosis new paradigm PCD, has received increasing attention due to its close association immunity disease. inflammatory mediated by gasdermin that promotes the release proinflammatory cytokines contents induced inflammasome activation. Recently, evidence studies shows pyroptosis crucial conditions like cardiovascular diseases (CVDs), cancer, neurological (NDs), metabolic (MDs), suggesting targeting potential intervention for treatment these diseases. Based on this, review aims identify molecular mechanisms signaling pathways related activation summarizes current insights into complicated relationship between multiple human (CVDs, NDs, MDs). We also discuss promising novel strategy method treating focus pathway application clinics.

Язык: Английский

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Effect of regulatory cell death on the occurrence and development of head and neck squamous cell carcinoma

Biomarker Research, Год журнала: 2023, Номер 11(1)

Опубликована: Янв. 5, 2023

Abstract Head and neck cancer is a malignant tumour with high mortality rate characterized by late diagnosis, recurrence metastasis rates, poor prognosis. squamous cell carcinoma (HNSCC) the most common type of head cancer. Various factors are involved in occurrence development HNSCC, including external inflammatory stimuli oncogenic viral infections. In recent years, studies on regulation death have provided new insights into biology therapeutic response such as apoptosis, necroptosis, pyroptosis, autophagy, ferroptosis, recently newly discovered cuproptosis. We explored how various deaths act unique defence mechanism against emergence they can be exploited to inhibit tumorigenesis progression, thus introducing regulatory (RCD) novel strategy for therapy. contrast accidental death, RCD controlled specific signal transduction pathways, TP53 signalling, KRAS NOTCH hypoxia metabolic reprogramming. this review, we describe molecular mechanisms nonapoptotic its relationship HNSCC discuss crosstalk between relevant signalling pathways cells. also highlight approaches elimination through RCD.

Язык: Английский

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Novel targets for gastric cancer: The tumor microenvironment (TME), N6-methyladenosine (m6A), pyroptosis, autophagy, ferroptosis and cuproptosis

Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 163, С. 114883 - 114883

Опубликована: Май 16, 2023

Gastric cancer (GC) is a fatal illness, and its mortality rate very high all over the world. At present, it serious health problem for any country. It multifactorial disease due to rising drug resistance increasing global burden, treatment of GC still faces many obstacles problems. In recent years, research on being carried out continuously, we hope address new targets through this review. same time, also discover ways fight create more gospel clinical patients. First, discuss descriptive tumor microenvironment (TME), N6-methyladenosine (m6A), pyroptosis, autophagy, ferroptosis, cuproptosis. Finally, expounded or potential treatment.

Язык: Английский

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Cell death pathways: molecular mechanisms and therapeutic targets for cancer

MedComm, Год журнала: 2024, Номер 5(9)

Опубликована: Сен. 1, 2024

Abstract Cell death regulation is essential for tissue homeostasis and its dysregulation often underlies cancer development. Understanding the different pathways of cell can provide novel therapeutic strategies battling cancer. This review explores several key mechanisms apoptosis, necroptosis, autophagic death, ferroptosis, pyroptosis. The research gap addressed involves a thorough analysis how these be precisely targeted therapy, considering tumor heterogeneity adaptation. It delves into genetic epigenetic factors signaling cascades like phosphatidylinositol 3‐kinase/protein kinase B/mammalian target rapamycin (PI3K/AKT/mTOR) mitogen‐activated protein kinase/extracellular signal‐regulated (MAPK/ERK) pathways, which are critical death. Additionally, interaction microenvironment with cells, particularly influence hypoxia, nutrient deprivation, immune cellular interactions, explored. Emphasizing strategies, this highlights emerging modulators inducers such as B lymphoma 2 (BCL2) homology domain 3 (BH3) mimetics, tumour necrosis factor‐related apoptosis‐inducing ligand (TRAIL), chloroquine, innovative approaches to induce ferroptosis provides insights therapy's future direction, focusing on multifaceted circumvent drug resistance. examination evolving underlines considerable clinical potential continuous necessity in‐depth exploration within scientific domain.

Язык: Английский

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Drug carrier wonders: Synthetic strategies of zeolitic imidazolates frameworks (ZIFs) and their applications in drug delivery and anti-cancer activity

Advances in Colloid and Interface Science, Год журнала: 2024, Номер 329, С. 103184 - 103184

Опубликована: Май 17, 2024

Язык: Английский

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Plasma membrane damage limits replicative lifespan in yeast and induces premature senescence in human fibroblasts

Nature Aging, Год журнала: 2024, Номер 4(3), С. 319 - 335

Опубликована: Фев. 22, 2024

Plasma membrane damage (PMD) occurs in all cell types due to environmental perturbation and cell-autonomous activities. However, cellular outcomes of PMD remain largely unknown except for recovery or death. In this study, using budding yeast normal human fibroblasts, we found that senescence-stable cycle arrest contributing organismal aging-is the long-term outcome PMD. Our genetic screening unexpectedly identified a close association between response replicative lifespan regulations. Furthermore, limits yeast; upregulation repair factors ESCRT-III (SNF7) AAA-ATPase (VPS4) extends it. induces premature senescence via Ca

Язык: Английский

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