Rhus coriaria (Sumac) induces autophagic cell death and inhibits mTOR, p38MAPK and STAT3 pathways in 5fluorouracil-resistant colorectal cancer cells DOI Creative Commons
Zohra Nausheen Nizami,

Mazoun Al Azzani,

Soumaya Khaldi

и другие.

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Март 19, 2025

Introduction Colorectal cancer is a leading cause of related-death worldwide, and resistance to 5-fluorouracil (5FU, key component chemotherapy regimens, major clinical concern. We have previously elucidated the effects Rhus coriaria ethanolic extract (RCE) in triple-negative breast cancer, CRC, pancreatic cells. Here, we explored anticancer RCE parental (HCT-116-WT) 5FU-resistant HCT-116 (HCT-116-5FU-R) CRC Methods MTT assay was used assess cell viability. Muse analyzer viability, cycle distribution, apoptosis. Additionally, colony formation growth assays western blots were performed. In vivo assessed by an ovo chick embryo tumor assay. Results found that inhibited viability capacities HCT-116-WT HCT-116-5FU-R The antiproliferative attributed DNA damage-mediated impairment at S phase, induction Beclin-1-independent autophagy both lines. Mechanistically, inhibition mTOR, STAT3 p38 MAPK pathways implicated latter. induced caspase-7-independent apoptosis However, cells resistant through upregulation survivin, downregulation Bax. Using proteasome inhibitors, clarified pathway contributed RCE-mediated death Lastly, confirmed xenografts model. Discussion Collectively, our findings highlight source phytochemicals can be as agents for CRC.

Язык: Английский

P53: A key player in diverse cellular processes including nuclear stress and ribosome biogenesis, highlighting potential therapeutic compounds DOI
Gazmend Temaj, Silvia Chichiarelli, Pelin Telkoparan‐Akillilar

и другие.

Biochemical Pharmacology, Год журнала: 2024, Номер 226, С. 116332 - 116332

Опубликована: Июнь 1, 2024

Язык: Английский

Процитировано

5
The role of LncRNA-mediated autophagy in cancer progression DOI Creative Commons

Zi-Yuan Liu,

Jiaming Tang,

Meng-Qi Yang

и другие.

Frontiers in Cell and Developmental Biology, Год журнала: 2024, Номер 12

Опубликована: Июнь 12, 2024

Long non-coding RNAs (lncRNAs) are a sort of transcripts that more than 200 nucleotides in length. In recent years, many studies have revealed the modulatory role lncRNAs cancer. Typically, linked to variety essential events, such as apoptosis, cellular proliferation, and invasion malignant cells. Simultaneously, autophagy, an intracellular degradation mechanism eukaryotic cells, is activated respond multiple stressful circumstances, for example, nutrient scarcity, accumulation abnormal proteins, organelle damage. Autophagy plays both suppressive promoting roles Increasingly, unveiled how dysregulated expression can disrupt autophagic balance, thereby contributing cancer progression. Consequently, exploring interplay between autophagy holds promising implications clinical research. this manuscript, we methodically compiled advances molecular mechanisms briefly summarized lncRNA-mediated axis.

Язык: Английский

Процитировано

5
Docking studies between Natural unsaturated Oleic-acid and a de novo lung cancer peptide of CHRNA3 (Cholinergic Receptor Nicotinic Alpha 3) using Insilico protocols DOI Creative Commons

Aadya. LN -

Опубликована: Янв. 18, 2025

Abstract Lung cancer, according to current clinical pharmacological studies, is among the most prevalent types of cancer. Polymorphisms in CHRNA3 gene have been associated with an increased risk smoking initiation and susceptibility lung In Insilico study, there were two major findings. First, novel 3D peptide was designed from genomic sequence CHRNA3. Next, we observe how Oleic acid interacts derived cancer using tools. The exonic converted into a protein which subject designing immuno-medicine protocols. modelled automated homology modelling server. binding affinities between control drug, 5-Fluorouracil test compound, Oleic-acid can be found CB Dock, drug docking results clearly elucidated that when compared existing anti-cancer 5-flourouracil, showed higher affinity Hence, added as supplementary drugs enhance their efficiency. acid, being natural one expect lesser side-effects. Our structure will available PDB-Dev (https://www.modelarchive.org/doi/10.5452/ma-m1plw). study revealed potential therapeutic agent for Carcinoma.

Язык: Английский

Процитировано

0
Recent advances in metallodrug: Coordination-induced synergy between clinically approved drugs and metal ions DOI Creative Commons
Won Kyu Kim, Jong Min An, Yun Seng Lim

и другие.

Materials Today Advances, Год журнала: 2025, Номер 25, С. 100569 - 100569

Опубликована: Фев. 24, 2025

Язык: Английский

Процитировано

0
Rhus coriaria (Sumac) induces autophagic cell death and inhibits mTOR, p38MAPK and STAT3 pathways in 5fluorouracil-resistant colorectal cancer cells DOI Creative Commons
Zohra Nausheen Nizami,

Mazoun Al Azzani,

Soumaya Khaldi

и другие.

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Март 19, 2025

Introduction Colorectal cancer is a leading cause of related-death worldwide, and resistance to 5-fluorouracil (5FU, key component chemotherapy regimens, major clinical concern. We have previously elucidated the effects Rhus coriaria ethanolic extract (RCE) in triple-negative breast cancer, CRC, pancreatic cells. Here, we explored anticancer RCE parental (HCT-116-WT) 5FU-resistant HCT-116 (HCT-116-5FU-R) CRC Methods MTT assay was used assess cell viability. Muse analyzer viability, cycle distribution, apoptosis. Additionally, colony formation growth assays western blots were performed. In vivo assessed by an ovo chick embryo tumor assay. Results found that inhibited viability capacities HCT-116-WT HCT-116-5FU-R The antiproliferative attributed DNA damage-mediated impairment at S phase, induction Beclin-1-independent autophagy both lines. Mechanistically, inhibition mTOR, STAT3 p38 MAPK pathways implicated latter. induced caspase-7-independent apoptosis However, cells resistant through upregulation survivin, downregulation Bax. Using proteasome inhibitors, clarified pathway contributed RCE-mediated death Lastly, confirmed xenografts model. Discussion Collectively, our findings highlight source phytochemicals can be as agents for CRC.

Язык: Английский

Процитировано

0