Journal of Personalized Medicine,
Год журнала:
2024,
Номер
14(11), С. 1092 - 1092
Опубликована: Ноя. 4, 2024
After
the
COVID-19
pandemic,
mRNA-based
vaccines
have
emerged
as
a
revolutionary
technology
in
immunization
and
vaccination.
These
shown
remarkable
efficacy
against
virus
opened
up
avenues
for
their
possible
application
other
diseases.
This
has
renewed
interest
investment
mRNA
vaccine
research
development,
attracting
scientific
community
to
explore
all
its
applications
beyond
infectious
Recently,
researchers
focused
on
possibility
of
adapting
this
vaccination
approach
cancer
immunotherapy.
While
there
is
huge
potential,
challenges
still
remain
design
optimization
synthetic
molecules
lipid
nanoparticle
delivery
system
required
ensure
adequate
elicitation
immune
response
successful
eradication
tumors.
review
points
out
basic
mechanisms
mRNA-LNP
immunotherapy
recent
approaches
design.
displays
current
modifications
components
how
these
factors
affect
efficacy.
Furthermore,
discusses
future
directions
clinical
treatment.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2023,
Номер
unknown
Опубликована: Дек. 5, 2023
The
interaction
between
peptides
and
major
histocompatibility
complex
(MHC)
molecules
is
pivotal
in
autoimmunity,
pathogen
recognition
tumor
immunity.
Recent
advances
cancer
immunotherapies
demand
for
more
accurate
computational
prediction
of
MHC-bound
peptides.
We
address
the
generalizability
challenge
peptide
predictions,
revealing
limitations
current
sequence-based
approaches.
Our
structure-based
methods
leveraging
geometric
deep
learning
(GDL)
demonstrated
promising
improvement
across
unseen
MHC
alleles.
Further,
we
tackle
data
efficiency
by
introducing
a
self-supervised
approach
on
structures
(3D-SSL).
Without
being
exposed
to
any
binding
affinity
data,
our
3D-SSL
outperforms
trained
~90
times
datapoints.
Finally,
demonstrate
resilience
GDL
biases
an
Hepatitis
B
virus
vaccine
immunopeptidomics
case
study.
This
proof-of-concept
study
highlights
methods'
potential
enhance
efficiency,
with
important
implications
data-intensive
fields
like
T-cell
receptor
specificity
paving
way
enhanced
comprehension
manipulation
immune
responses.
Cancer Prevention Research,
Год журнала:
2024,
Номер
17(11), С. 499 - 515
Опубликована: Июль 30, 2024
Abstract
Currently,
eight
million
people
in
the
United
States
suffer
from
cancer
and
it
is
a
major
global
health
concern.
Early
detection
interventions
are
urgently
needed
for
all
cancers,
including
colorectal
cancer.
Colorectal
third
most
common
type
of
worldwide.
Based
on
diagnostic
efforts
to
general
awareness
lifestyle
choices,
understandable
why
so
prevalent
today.
There
notable
lack
concerning
impact
this
its
connection
elements,
as
well
sometimes
mistaking
symptoms
different
gastrointestinal
condition.
Artificial
intelligence
(AI)
may
assist
early
The
usage
AI
has
exponentially
grown
healthcare
through
extensive
research,
since
clinical
implementation,
succeeded
improving
patient
lifestyles,
modernizing
processes,
innovating
current
treatment
strategies.
Numerous
challenges
arise
patients
with
oncologists
alike
during
treatment.
For
initial
screening
phases,
conventional
methods
often
result
misdiagnosis.
Moreover,
after
detection,
determining
course
which
can
contribute
delays.
This
article
touches
recent
advancements
application
while
shedding
light
disease
Journal of Personalized Medicine,
Год журнала:
2024,
Номер
14(11), С. 1092 - 1092
Опубликована: Ноя. 4, 2024
After
the
COVID-19
pandemic,
mRNA-based
vaccines
have
emerged
as
a
revolutionary
technology
in
immunization
and
vaccination.
These
shown
remarkable
efficacy
against
virus
opened
up
avenues
for
their
possible
application
other
diseases.
This
has
renewed
interest
investment
mRNA
vaccine
research
development,
attracting
scientific
community
to
explore
all
its
applications
beyond
infectious
Recently,
researchers
focused
on
possibility
of
adapting
this
vaccination
approach
cancer
immunotherapy.
While
there
is
huge
potential,
challenges
still
remain
design
optimization
synthetic
molecules
lipid
nanoparticle
delivery
system
required
ensure
adequate
elicitation
immune
response
successful
eradication
tumors.
review
points
out
basic
mechanisms
mRNA-LNP
immunotherapy
recent
approaches
design.
displays
current
modifications
components
how
these
factors
affect
efficacy.
Furthermore,
discusses
future
directions
clinical
treatment.
