Applied Sciences,
Год журнала:
2022,
Номер
12(19), С. 9928 - 9928
Опубликована: Окт. 2, 2022
Honey
has
a
history
of
medical
use
and
is
known
as
bio-alternative
therapy.
This
research
assessed
the
phytochemical
biological
activity
grade
manuka
honey
(MH).
Gas
chromatography–mass
spectrometry
(GC–MS)
was
chosen
to
investigate
bioactive
compounds
MH.
The
DPPH
ABTS
free
radical
scavenging
beta-carotene
antioxidant
activities
well
antibacterial
antibiofilm
effects
against
S.
aureus,
B.
subtilis,
E.
coli
P.
aeruginosa
were
all
determined.
Furthermore,
gauge
anticancer
properties
MH,
MTT
assay
opted
towards
three
cell
lines,
including
HCT-116
(colon),
A549
(lung)
MCF-7
(breast)
cancer
cells.
GC–MS
analysis
tested
MH
revealed
identification
various
chemical
constituents
belonging
fatty
acids,
phenols,
esters.
found
have
higher
reducing
power
(DPPH
IC50:
7.36;
4.49
mg/mL)
than
bleaching
(IC50:
37.51
mg/mL).
Similarly,
noted
be
more
active
planktonic
biofilm
Gram-positive
bacteria.
dose-dependent
potential
observed,
although
significant
pointed
out
conforming
IC50
values
9.05
9.37
mg/mL,
respectively.
study’s
results
highlighted
MH’s
composition
with
bioactivities.
Antioxidants,
Год журнала:
2022,
Номер
11(12), С. 2388 - 2388
Опубликована: Дек. 1, 2022
Antioxidants
have
been
widely
studied
in
the
fields
of
biology,
medicine,
food,
and
nutrition
sciences.
There
has
extensive
work
on
developing
assays
for
foods
biological
systems.
The
scientific
communities
well-accepted
effectiveness
endogenous
antioxidants
generated
body.
However,
health
efficacy
possible
action
exogenous
dietary
are
still
questionable.
This
may
be
attributed
to
several
factors,
including
a
lack
basic
understanding
interaction
body,
agreement
different
antioxidant
assays,
specificity
which
leads
an
inability
relate
specific
outcomes.
Hence,
there
is
significant
doubt
regarding
relationship
between
human
health.
In
this
review,
we
documented
variations
current
methodologies,
their
mechanisms,
highly
varying
values
six
common
food
substrates
(fruits,
vegetables,
processed
foods,
grains,
legumes,
milk,
dairy-related
products).
Finally,
discuss
strengths
weaknesses
examine
challenges
correlating
activity
Cells,
Год журнала:
2022,
Номер
11(16), С. 2518 - 2518
Опубликована: Авг. 13, 2022
Mitochondria
are
not
only
the
main
energy
supplier
but
also
cell
metabolic
center
regulating
multiple
key
metaborates
that
play
pivotal
roles
in
epigenetics
regulation.
These
metabolites
include
acetyl-CoA,
α-ketoglutarate
(α-KG),
S-adenosyl
methionine
(SAM),
NAD+,
and
O-linked
beta-N-acetylglucosamine
(O-GlcNAc),
which
substrates
for
DNA
methylation
histone
post-translation
modifications,
essential
gene
transcriptional
regulation
fate
determination.
Tumorigenesis
is
attributed
to
many
factors,
including
mutations
tumor
microenvironment.
initiation,
evolution,
metastasis,
recurrence.
Targeting
mitochondrial
metabolism
promising
therapeutic
strategies
treatment.
In
this
review,
we
summarize
of
mitochondria
required
modification
discuss
current
strategy
cancer
therapies
via
targeting
epigenetic
modifiers
related
enzymes
This
review
an
important
contribution
understanding
metabolic-epigenetic-tumorigenesis
concept.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(7), С. 6192 - 6192
Опубликована: Март 24, 2023
The
study
aimed
to
perform
a
systematic
review
and
meta-analysis
of
the
evidence
for
prevention
future
cancers
following
bariatric
surgery.
A
literature
search
Cochrane
Library,
Embase,
Scopus,
Web
Science
PubMed
databases
(2007–2023),
Google
Scholar
grey
was
conducted.
performed
using
inverse
variance
method
random
effects
model.
Thirty-two
studies
involving
patients
with
obesity
who
received
surgery
control
were
managed
conventional
treatment
included.
suggested
associated
reduced
overall
incidence
cancer
(RR
0.62,
95%
CI
0.46–0.84,
p
<
0.002),
obesity-related
0.59,
0.39–0.90,
=
0.01)
cancer-associated
mortality
0.51,
0.42–0.62,
0.00001).
In
specific
cancers,
reduction
in
hepatocellular
carcinoma
0.35,
0.22–0.55,
0.00001),
colorectal
0.63,
0.50–0.81,
0.0002),
pancreatic
0.52,
0.29–0.93,
0.03)
gallbladder
0.41,
0.18–0.96,
0.04),
as
well
female
including
breast
0.56,
0.44–0.71,
endometrial
0.38,
0.26–0.55,
0.00001)
ovarian
0.45,
0.31–0.64,
0.0001).
There
no
significant
oesophageal,
gastric,
thyroid,
kidney,
prostate
or
multiple
myeloma
after
compared
morbid
did
not
have
Obesity-associated
carcinogenesis
is
closely
related
metabolic
syndrome;
visceral
adipose
dysfunction;
aromatase
activity
detrimental
cytokine,
adipokine
exosomal
miRNA
release.
Bariatric
results
long-term
weight
loss
morbidly
obese
improves
syndrome.
may
decrease
mortality,
seven
cancers.
Journal of Chemistry,
Год журнала:
2024,
Номер
2024, С. 1 - 21
Опубликована: Май 31, 2024
Absorption
of
free
radicals
in
the
body
cannot
be
done
by
antioxidant
compounds
originating
from
human
body,
so
exogenous
antioxidants
are
required
to
help
their
natural
action.
Oxidative
stress
can
caused
an
imbalance
radical
inhibitors
and
accumulation
that
enter
cellular
structures.
Synthetic
found
external
not
primary
choice
because
they
harmful
carcinogenic.
Therefore,
using
ingredients
provides
a
necessary
alternative
constructing
novel
antioxidants.
Recent
studies
have
highlighted
critical
analysis
evaluation
flavonoids
unique
class
secondary
metabolites
plants
used
communities
as
traditional
therapeutics
with
proven
bioactivity.
This
could
support
new
discoveries
based
on
various
herbal
medicines
addition,
functional
effectiveness
against
radicals.
In
this
review,
there
several
strengths
discussion.
First,
study
takes
comprehensive
approach
covering
aspects,
including
properties
sources
radicals,
oxidative
relation
different
diseases,
defense
mechanisms,
specific
mechanisms
flavonoids.
Second,
focus
antioxidants,
especially
flavonoids,
also
discussion
about
clinical
applications
studies,
limitations,
global
perspectives,
future
research
directions
become
references
selection
medicines.
But,
constraints
should
considered
when
interpreting
findings
review.
mechanism
is
only
discussed
general
one
example
compound
(flavonoid)
has
potential
antioxidant.
lack
regarding
relationship
between
diseases
Third,
limited
number
investigated
some
discussed.
Cancers,
Год журнала:
2022,
Номер
14(21), С. 5444 - 5444
Опубликована: Ноя. 5, 2022
Breast
cancer
remains
the
most
frequently
diagnosed
form
of
female's
cancer,
and
in
recent
years
it
has
become
common
cause
death
women
worldwide.
Like
many
other
tumours,
breast
is
a
histologically
biologically
heterogeneous
disease.
In
years,
considerable
progress
been
made
diagnosis,
subtyping,
complex
treatment
with
aim
providing
best
suited
tumour-specific
personalized
therapy.
Traditional
methods
for
diagnosis
include
mammography,
MRI,
biopsy
histological
analysis
tumour
tissue
order
to
determine
classical
markers
such
as
estrogen
progesterone
receptors
(ER,
PR),
cytokeratins
(CK5/6,
CK14,
C19),
proliferation
index
(Ki67)
human
epidermal
growth
factor
type
2
receptor
(HER2).
these
have
supplemented
by
modern
molecular
methodologies
next-generation
sequencing,
microRNA,
situ
hybridization,
RT-qPCR
identify
novel
biomarkers.
MicroRNAs
(miR-10b,
miR-125b,
miR145,
miR-21,
miR-155,
mir-30,
let-7,
miR-25-3p),
altered
DNA
methylation
mutations
specific
genes
(p16,
BRCA1,
RASSF1A,
APC,
GSTP1),
circular
RNA
(hsa_circ_0072309,
hsa_circRNA_0001785),
circulating
cells,
levels
proteins
(apolipoprotein
C-I),
lipids,
gene
polymorphisms
or
nanoparticle
enhanced
imaging,
all
are
promising
diagnostic
prognostic
tools
disclose
any
features
from
multifaceted
nature
prepare
individualized
Antioxidants,
Год журнала:
2022,
Номер
11(10), С. 2071 - 2071
Опубликована: Окт. 20, 2022
Lipid
peroxidation,
including
its
prominent
byproducts
such
as
malondialdehyde
(MDA)
and
4-hydroxy-2-nonenal
(4-HNE),
has
long
been
linked
with
worsened
metabolic
health
in
patients
type
2
diabetes
(T2D).
In
fact,
T2D
already
display
increased
levels
of
lipids
circulation,
low-density
lipoprotein-cholesterol
triglycerides,
which
are
easily
attacked
by
reactive
oxygen
molecules
to
give
rise
lipid
peroxidation.
This
process
severely
depletes
intracellular
antioxidants
cause
excess
generation
oxidative
stress.
consequence
mainly
drives
poor
glycemic
control
complications
that
implicated
the
development
cardiovascular
disease.
The
current
review
explores
pathological
relevance
elevated
peroxidation
products
T2D,
especially
highlighting
their
potential
role
biomarkers
therapeutic
targets
disease
severity.
addition,
we
briefly
explain
implication
some
antioxidant
enzymes/factors
involved
blockade
termination
reactions
involve
effect
antioxidants,
catalase,
coenzyme
Q10,
glutathione
peroxidase,
superoxide
dismutase,
well
vitamins
C
E.
Metabolites,
Год журнала:
2023,
Номер
13(5), С. 675 - 675
Опубликована: Май 21, 2023
The
present
study
aims
to
provide
a
narrative
review
of
the
molecular
mechanisms
Western
diet-induced
obesity
and
obesity-related
carcinogenesis.
A
literature
search
Cochrane
Library,
Embase
Pubmed
databases,
Google
Scholar
grey
was
conducted.
Most
that
induce
are
also
involved
in
twelve
Hallmarks
Cancer,
with
fundamental
process
being
consumption
highly
processed,
energy-dense
diet
deposition
fat
white
adipose
tissue
liver.
generation
crown-like
structures,
macrophages
surrounding
senescent
or
necrotic
adipocytes
hepatocytes,
leads
perpetual
state
chronic
inflammation,
oxidative
stress,
hyperinsulinaemia,
aromatase
activity,
activation
oncogenic
pathways
loss
normal
homeostasis.
Metabolic
reprogramming,
epithelial
mesenchymal
transition,
HIF-1α
signalling,
angiogenesis
host
immune-surveillance
particularly
important.
Obesity-associated
carcinogenesis
is
closely
related
metabolic
syndrome,
hypoxia,
visceral
dysfunction,
oestrogen
synthesis
detrimental
cytokine,
adipokine
exosomal
miRNA
release.
This
important
pathogenesis
oestrogen-sensitive
cancers,
including
breast,
endometrial,
ovarian
thyroid
cancer,
but
‘non-hormonal’
obesity-associated
cancers
such
as
cardio-oesophageal,
colorectal,
renal,
pancreatic,
gallbladder
hepatocellular
adenocarcinoma.
Effective
weight
interventions
may
improve
future
incidence
overall
cancer.
Antioxidants,
Год журнала:
2023,
Номер
12(1), С. 155 - 155
Опубликована: Янв. 9, 2023
The
contention
that
flavonoids'
oxidation
would
necessarily
lead
to
a
loss
of
their
antioxidant
properties
was
recently
challenged
by
the
demonstration
quercetin
leads
formation
2-(3,4-dihydroxybenzoyl)-2,4,6-trihydroxy-3(2H)-benzofuranone
(Que-BZF),
metabolite
whose
potency
notably
higher
than
its
precursor.
Here,
we
compared
and
expanded
former
observation
analogue
kaempferol.
Oxidation
kaempferol
led
mixture
metabolites
included
2-(4-hydroxybenzoyl)-2,4,6-trihydroxy-3(2H)-benzofuranone
(Kae-BZF).
Following
chromatographic
isolation
Kae-BZF
from
such
mixture,
antioxidant,
mitochondria-
cell-protecting,
NF-kB-inhibiting
effects
were
assessed,
with
those
Que-BZF,
in
Caco-2
cells
exposed
indomethacin
as
source
ROS.
concentrations
Que-BZF
(100
nm)
(1
needed
attain
maximal
protection
50-
5000-fold
lower
respective
precursors.
differences
also
seen
when
abilities
inhibit
indomethacin-induced
activation
NF-kB
compared.
These
data
not
only
reveal
oxidative
conversion
into
2-benzoyl-2-hydroxy-3(2H)-benzofuranones
(BZF)
results
considerable
amplification
original
properties,
but
case
kaempferol,
is
100-fold
greater
quercetin.
Cell Communication and Signaling,
Год журнала:
2024,
Номер
22(1)
Опубликована: Май 2, 2024
Abstract
Anticancer
immune
surveillance
and
immunotherapies
trigger
activation
of
cytotoxic
cytokine
signaling,
including
tumor
necrosis
factor-α
(TNF-α)
TNF-related
apoptosis-inducing
ligand
(TRAIL)
pathways.
The
pro-inflammatory
TNF-α
may
be
secreted
by
stromal
cells,
tumor-associated
macrophages,
cancer
indicating
a
prominent
role
in
the
microenvironment
(TME).
However,
tumors
manage
to
adapt,
escape
surveillance,
ultimately
develop
resistance
effects
TNF-α.
mechanisms
which
cells
evade
host
immunity
is
central
topic
current
research.
Resistance
mediated
diverse
molecular
mechanisms,
such
as
mutation
or
downregulation
TNF/TRAIL
receptors,
well
anti-apoptotic
enzymes
transcription
factors.
signaling
also
sphingosine
kinases
(SphK1
SphK2),
are
responsible
for
synthesis
growth-stimulating
phospholipid,
sphingosine-1-phosphate
(S1P).
Multiple
studies
have
demonstrated
crucial
S1P
its
transmembrane
receptors
(S1PR)
both
regulation
inflammatory
responses
progression
cancer.
Considering
that
SphK/S1P/S1PR
axis
mediates
resistance,
this
sphingolipid
pathway
mechanistic
significance
when
considering
immunotherapy-resistant
malignancies.
exact
mechanism
sphingolipids
contribute
evasion
abrogation
TNF-α-induced
apoptosis
remains
largely
unclear.
This
study
reviews
TNF-α-resistance
with
emphasis
on
pro-survival
immunomodulatory
sphingolipids.
Inhibition
SphK/S1P-linked
branch
facilitate
reactivation
pro-apoptotic
TNF
superfamily
effects,
although
SphK/S1P
inhibitors
TME
lymphocyte
trafficking
should
thoroughly
assessed
future
studies.
Healthcare,
Год журнала:
2024,
Номер
12(4), С. 416 - 416
Опубликована: Фев. 6, 2024
Obesity
has
become
a
global
health
concern,
with
its
prevalence
steadily
increasing
in
recent
decades.
It
is
associated
numerous
complications,
including
cardiovascular
diseases,
diabetes,
and
certain
types
of
cancer.
The
aetiology
obesity
multifactorial,
involving
genetic,
environmental,
lifestyle
factors.
In
years,
oxidative
stress
emerged
as
potential
contributor
to
related
metabolic
disorders.
Dietary
antioxidants,
which
can
counteract
stress,
have
gained
significant
attention
for
their
role
preventing
managing
obesity.
This
comprehensive
review
aims
explore
the
impact
dietary
antioxidants
on
dysregulations,
discussing
underlying
mechanisms
highlighting
therapeutic
implications.