Plants,
Год журнала:
2023,
Номер
12(14), С. 2661 - 2661
Опубликована: Июль 16, 2023
Transdermal
delivery
devices
and
wound
dressing
materials
are
constantly
improved
upgraded
with
the
aim
of
enhancing
their
beneficial
effects,
biocompatibility,
biodegradability,
cost
effectiveness.
Therefore,
researchers
in
field
have
shown
an
increasing
interest
using
natural
compounds
as
constituents
for
such
systems.
Plants,
important
source
so-called
“natural
products”
enormous
variety
structural
diversity
that
still
exceeds
capacity
present-day
sciences
to
define
or
even
discover
them,
been
part
medicine
since
ancient
times.
However,
benefits
just
at
beginning
being
fully
exploited
modern
dermal
transdermal
Thus,
plant-based
primary
compounds,
without
biological
activity,
contained
gums
mucilages,
traditionally
used
gelling
texturing
agents
food
industry,
now
explored
valuable
cost-effective
components
biomedical
field.
Their
non-toxicity
compensate
local
availability
compositional
variations.
Also,
secondary
metabolites,
classified
based
on
chemical
structure,
intensively
investigated
wide
pharmacological
toxicological
effects.
impact
is
highlighted
detail
through
most
recent
reported
studies.
Innovative
isolation
purification
techniques,
new
drug
systems,
advanced
evaluation
procedures
presented.
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Март 13, 2025
The
latest
research
on
nanotechnology
through
the
new
tailored
scaffolds
encompassed
therapeutic
effects
of
natural
compounds,
and
unique
properties
metallic
nanoparticles
offer
possibilities
in
emerging
biomedical
fields.
Various
strategies
have
been
developed
to
address
limitations
existing
agents
concerning
specificity,
vectorization,
bioavailability,
drug
resistance,
adverse
effects.
In
this
study,
medicinal
plant
Portulaca
oleracea
L.
magnetite
were
used
develop
an
innovative
target
carrier
system,
designed
enhance
cytotoxic
effect
overcome
main
drawbacks
(permeability
localization)
phytoconstituents.
low-metabolite
profile
Romanian
wild-grown
exhibits
a
diverse
range
hundred
fifty-five
compounds
across
various
chemical
categories
(amino
acids,
peptides,
fatty
flavonoids,
alkaloids,
terpenoids,
phenolic
organic
esters,
sterols,
coumarins,
nucleosides,
lignans,
miscellaneous
compounds).
Morpho-structural
magnetic
phytocarrier
investigated
using
variety
methods,
including
XRD,
FTIR,
Raman,
SEM,
DLS),
determinations.
MTT
assay
was
conducted
evaluate
vitro
potential
cytotoxicity
normal
human
dermal
fibroblasts
(NHDF),
as
well
two
tumoral
cell
lines:
osteosarcoma
(HOS)
cervical
cancer
(HeLa).
Results
indicated
that
significant
inhibition
both
lines'
viability
exerted
by
compared
herbal
extract.
Furthermore,
results
obtained
for
total
content
antioxidant
screening
performed
FRAP
DPPH
assays
superior
system.
These
findings
suggest
applications
system
its
promising
implications
future
development
field.
European Journal of Medicinal Chemistry,
Год журнала:
2025,
Номер
290, С. 117535 - 117535
Опубликована: Март 20, 2025
Cancer
drug
delivery
remains
a
critical
challenge
with
systemic
toxicity,
poor
bioavailability,
and
lack
of
effective
targeting.
Overcoming
these
barriers
is
essential
for
improving
treatment
efficacy
patient
outcomes.
This
review
discusses
current
techniques
that
reshape
cancer
therapy
by
offering
precise,
controlled-release
tailored
to
tumor-specific
features.
Innovations
in
nanotechnology,
immunotherapy,
gene
enable
interventions
at
molecular
cellular
levels.
Radiomics
pathomics
integrate
high-dimensional
data
optimize
diagnostics
planning.
Combination
addresses
the
complexities
tumor
heterogeneity
synergizing
multiple
agents
within
single
therapeutic
framework,
while
peptide-drug
conjugates
enhance
specificity
potency.
Hydrogel-based
systems
microneedle
arrays
offer
localized,
sustained
release,
significantly
However,
clinical
translation
advancements
faces
significant
such
as
resistance,
off-target
effects,
scalability,
cost,
ethical
concerns.
Moreover,
regulatory
economic
feasibility
therapies
highlight
need
innovative
frameworks
make
them
accessible
globally.
Therefore,
there
innovation
cell
therapy,
next-generation
platforms,
personalized
medicine.
focuses
on
recent
over
past
decade,
evaluating
their
limitations
exploring
potential
future
directions
transforming
treatment.
Food Hydrocolloids for Health,
Год журнала:
2022,
Номер
3, С. 100110 - 100110
Опубликована: Дек. 9, 2022
Bee
pollen
extract
(BPE)
based
polymer
nanoparticles
(BPENP)
were
fabricated
in
the
current
study
by
using
bovine
serum
albumin
(BSA)
and
complex
was
then
coated
folic
acid
conjugated
protamine
to
be
targeted
for
cancer
cells.
Spectroscopic
microscopic
methods
used
characterize
resultant
nanoparticles.
High
flavonoid
polyphenolic
contents
detected
HPLC.
At
336
nm,
it
found
that
BPENP
provided
highest
absorption
UV.
The
average
particle
size
ranged
between
25
40
nm.
inhibitory
effects
IC50
values
of
acquired
BPE,
BPENP,
Avastin,
or
their
combination
at
24
48
h
against
A549
lung
therapy
assay
Avastin
revealed
a
very
significant
synergism
two
drugs
with
low
index
(CI).
These
therapies
particularly
have
significantly
affected
expression
HRAS,
MAPK,
apoptotic
genes
such
as
Bax,
Bcl-2,
Caspase
3.
It
established
obtained
might
employed
support
administration
treatment
cancer.
Pharmaceutics,
Год журнала:
2023,
Номер
15(6), С. 1771 - 1771
Опубликована: Июнь 20, 2023
This
study
aimed
to
improve
the
anticancer
effect
of
Cordyceps
militaris
herbal
extract
(CME)
on
breast
cancer
cells
with
hyaluronic
acid
(HYA)
surface-decorated
lipid
polymer
hybrid
nanoparticles
(LPNPs)
and
evaluate
applicability
a
synthesized
poly(glycerol
adipate)
(PGA)
for
LPNP
preparation.
Firstly,
cholesterol-
vitamin
E-grafted
PGA
polymers
(PGA-CH
PGA-VE,
respectively)
were
fabricated,
without
maleimide-ended
polyethylene
glycol.
Subsequently,
CME,
which
contained
an
active
cordycepin
equaling
9.89%
its
weight,
was
encapsulated
in
LPNPs.
The
results
revealed
that
could
be
used
prepare
CME-loaded
formulations
containing
Mal-PEG
decorated
cysteine-grafted
HYA
via
thiol-maleimide
reactions.
HYA-decorated
PGA-based
LPNPs
substantially
enhanced
CME
against
MDA-MB-231
MCF-7
by
enhancing
cellular
uptake
through
CD44
receptor-mediated
endocytosis.
demonstrated
successful
targeted
delivery
receptors
tumor
HYA-conjugated
new
application
PGA-CH-
PGA-VE-based
developed
showed
promising
potential
extracts
treatment
clear
translation
vivo
experiments.
Plants,
Год журнала:
2023,
Номер
12(14), С. 2661 - 2661
Опубликована: Июль 16, 2023
Transdermal
delivery
devices
and
wound
dressing
materials
are
constantly
improved
upgraded
with
the
aim
of
enhancing
their
beneficial
effects,
biocompatibility,
biodegradability,
cost
effectiveness.
Therefore,
researchers
in
field
have
shown
an
increasing
interest
using
natural
compounds
as
constituents
for
such
systems.
Plants,
important
source
so-called
“natural
products”
enormous
variety
structural
diversity
that
still
exceeds
capacity
present-day
sciences
to
define
or
even
discover
them,
been
part
medicine
since
ancient
times.
However,
benefits
just
at
beginning
being
fully
exploited
modern
dermal
transdermal
Thus,
plant-based
primary
compounds,
without
biological
activity,
contained
gums
mucilages,
traditionally
used
gelling
texturing
agents
food
industry,
now
explored
valuable
cost-effective
components
biomedical
field.
Their
non-toxicity
compensate
local
availability
compositional
variations.
Also,
secondary
metabolites,
classified
based
on
chemical
structure,
intensively
investigated
wide
pharmacological
toxicological
effects.
impact
is
highlighted
detail
through
most
recent
reported
studies.
Innovative
isolation
purification
techniques,
new
drug
systems,
advanced
evaluation
procedures
presented.
