Advances in Genomic Data and Biomarkers: Revolutionizing NSCLC Diagnosis and Treatment

Cancers, Год журнала: 2023, Номер 15(13), С. 3474 - 3474

Опубликована: Июль 3, 2023

Non-small cell lung cancer (NSCLC) is a significant public health concern with high mortality rates. Recent advancements in genomic data, bioinformatics tools, and the utilization of biomarkers have improved possibilities for early diagnosis, effective treatment, follow-up NSCLC. Biomarkers play crucial role precision medicine by providing measurable indicators disease characteristics, enabling tailored treatment strategies. The integration big data artificial intelligence (AI) further enhances potential personalized through advanced biomarker analysis. However, challenges remain impact new on efficacy due to limited evidence. Data analysis, interpretation, adoption approaches clinical practice pose additional emphasize technologies such as analysis (AI), which enhance Despite these obstacles, into has shown promising results NSCLC, improving patient outcomes targeted therapies. Continued research discovery, utilization, evidence generation are necessary overcome medicine. Addressing obstacles will contribute continued improvement non-small cancer.

Язык: Английский

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Lung Cancer—Epidemiology, Pathogenesis, Treatment and Molecular Aspect (Review of Literature)

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(5), С. 2049 - 2049

Опубликована: Фев. 26, 2025

Lung cancer is one of the most common malignant cancers in countries and leading cause death among diseases worldwide. Despite constant progress diagnosis therapy, survival rates patients diagnosed with lung remain unsatisfactory. Numerous epidemiological experimental studies conducted as early 1970s confirm that important risk factor for development long-term smoking, which remains valid to this day. In paper, authors present latest data on epidemiology, pathogenesis, treatment molecular aspects cancer. last decade, many alterations are effective have been discovered. adenocarcinoma, tyrosine kinase inhibitors were developed EGFR mutations ALK ROS1 translocations approved use advanced stage adenocarcinomas. case squamous cell carcinoma, evaluation these not yet being used clinical practice. addition, there ongoing concerning potential therapeutic targets, such ROS, MET, FGFR, DDR-2 RET. Constant diagnostic methods gives rise hopes an improved prognosis

Язык: Английский

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Superparamagnetic Iron Oxide Nanoparticles Reprogram the Tumor Microenvironment and Reduce Lung Cancer Regrowth after Crizotinib Treatment

ACS Nano, Год журнала: 2024, Номер 18(17), С. 11025 - 11041

Опубликована: Апрель 16, 2024

ALK-positive NSCLC patients demonstrate initial responses to ALK tyrosine kinase inhibitor (TKI) treatments, but eventually develop resistance, causing rapid tumor relapse and poor survival rates. Growing evidence suggests that the combination of drug immune therapies greatly improves patient survival; however, due low immunogenicity tumors, do not respond currently available immunotherapies. Tumor-associated macrophages (TAMs) play a crucial role in facilitating lung cancer growth by suppressing tumoricidal activation absorbing chemotherapeutics. However, they can also be programmed toward pro-inflammatory suppressive phenotype, which represents highly active area therapy development. Iron loading TAMs achieve such reprogramming correlating with an improved prognosis patients. We previously showed superparamagnetic iron oxide nanoparticles containing core-cross-linked polymer micelles (SPION-CCPMs) target stimulate activation. Here, we show SPION-CCPMs secrete reactive nitrogen species cytokines exert activity. further reshape immunosuppressive

Язык: Английский

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Biological Activity of Natural and Synthetic Peptides as Anticancer Agents

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(13), С. 7264 - 7264

Опубликована: Июль 1, 2024

Cancer is one of the leading causes morbidity and death worldwide, making it a serious global health concern. Chemotherapy, radiotherapy, surgical treatment are most used conventional therapeutic approaches, although they show several side effects that limit their effectiveness. For these reasons, discovery new effective alternative therapies still represents an enormous challenge for tumour diseases. Recently, anticancer peptides (ACPs) have gained attention cancer diagnosis treatment. ACPs small bioactive molecules which selectively induce cell through variety mechanisms such as apoptosis, membrane disruption, DNA damage, immunomodulation, well inhibition angiogenesis, survival, proliferation pathways. can also be employed targeted delivery drugs into cells. With over 1000 clinical trials using ACPs, potential application in therapy seems promising. Peptides utilized conjunction with imaging agents molecular methods, MRI, PET, CT, NIR, improving detection classification cancer, monitoring response. In this review we will provide overview biological activity some natural synthetic common malignant tumours affecting people around world.

Язык: Английский

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Revolutionizing anti-cancer drug discovery against breast cancer and lung cancer by modification of natural genistein: an advanced computational and drug design approach

Frontiers in Oncology, Год журнала: 2023, Номер 13

Опубликована: Сен. 25, 2023

Breast and lung cancer are two of the most lethal forms cancer, responsible for a disproportionately high number deaths worldwide. Both doctors patients express alarm about rising incidence disease globally. Although targeted treatment has achieved enormous advancements, it is not without its drawbacks. Numerous medicines chemotherapeutic drugs have been authorized by FDA; nevertheless, they can be quite costly often fall short completely curing condition. Therefore, this investigation conducted to identify potential medication against breast through structural modification genistein. Genistein active compound in Glycyrrhiza glabra (licorice), exhibits solid anticancer efficiency various cancers, including brain cancer. Hence, design analogs with interchange five functional groups-COOH, NH2 OCH3, Benzene, NH-CH2-CH2-OH-have employed enhance affinities compared primary Additionally, advanced computational studies such as PASS prediction, molecular docking, ADMET, dynamics simulation were conducted. Firstly, prediction spectrum was analyzed, revealing that designed genistein exhibit improved antineoplastic activity. In data, selected targets. Subsequently, other investigations gradually The mentioned compounds shown acceptable results silico ADME, AMES toxicity, hepatotoxicity estimations, which fundamental their oral medication. It noteworthy initial binding affinity only -8.7 kcal/mol protein (PDB ID: 3HB5). However, after group, when calculating affinities, becomes apparent increase gradually, reaching maximum -11.0 -10.0 kcal/mol. Similarly, -8.0 2P85), but addition affinity, reached -9.5 Finally, study models over 100 ns examine stability docked complexes. indicate complexes remain highly stable throughout 100-ns runs, displaying strong correlations ligands within site protein. important further investigate proceed clinical or wet lab experiments determine practical value proposed compounds.

Язык: Английский

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Nanoparticles overcome adaptive immune resistance and enhance immunotherapy via targeting tumor microenvironment in lung cancer

Frontiers in Pharmacology, Год журнала: 2023, Номер 14

Опубликована: Март 24, 2023

Lung cancer is one of the common malignant cancers worldwide. Immune checkpoint inhibitor (ICI) therapy has improved survival lung patients. However, ICI leads to adaptive immune resistance and displays PD-1/PD-L1 blockade in cancer, leading less response Tumor microenvironment (TME) an integral tumor microenvironment, which involved immunotherapy resistance. Nanomedicine been used enhance cancer. In this review article, we described association between TME We also highlighted importance Moreover, discussed how nanoparticles are regulation improve efficacy immunotherapy, including SGT-53, AZD1080, Nanomodulator NRF2, Cisplatin nanoparticles, Au@PG, DPAICP@ME, SPIO NP@M-P, NBTXR3 ARAC Nano-DOX, MS NPs, Nab-paclitaxel, GNPs-hPD-L1 siRNA. Furthermore, concluded that targeting by could be helpful overcome

Язык: Английский

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A review on non-small cell lung cancer

Vacunas, Год журнала: 2024, Номер 25(2), С. 239 - 253

Опубликована: Янв. 11, 2024

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Investigation of the Anticancer Effect of Newly Synthesized Palladium Conjugate Schiff Base Metal Complexes on Non-Small Cell Lung Cancer Cell Line and Mouse Embryonic Fibroblast Cell Line

Biochemical and Biophysical Research Communications, Год журнала: 2024, Номер 735, С. 150658 - 150658

Опубликована: Сен. 4, 2024

Язык: Английский

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Umbilical cord mesenchymal stem cells and lung cancer: We should be hopeful or hopeless?

Tissue and Cell, Год журнала: 2024, Номер 88, С. 102410 - 102410

Опубликована: Май 18, 2024

Язык: Английский

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PET Radiomics and Response to Immunotherapy in Lung Cancer: A Systematic Review of the Literature

Cancers, Год журнала: 2023, Номер 15(12), С. 3258 - 3258

Опубликована: Июнь 20, 2023

The aim of this review is to provide a comprehensive overview the existing literature concerning applications positron emission tomography (PET) radiomics in lung cancer patient candidates or those undergoing immunotherapy.

Язык: Английский

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