miRNAs in pancreatic cancer progression and metastasis

Clinical & Experimental Metastasis, Год журнала: 2024, Номер 41(3), С. 163 - 186

Опубликована: Янв. 19, 2024

Abstract Small non-coding RNA or microRNA (miRNA) are critical regulators of eukaryotic cells. Dysregulation miRNA expression and function has been linked to a variety diseases including cancer. They play complex role in cancers, having both tumour suppressor promoter properties. In addition, single can be involved regulating several mRNAs many miRNAs regulate mRNA, therefore assessing these roles is essential better understanding cancer initiation development. Pancreatic leading cause death worldwide, part due the lack diagnostic tools limited treatment options. The most common form pancreatic cancer, ductal adenocarcinoma (PDAC), characterised by major genetic mutations that drive progression. regulation interaction with driving suggests strong link between two. Understanding this PDAC progression may give rise novel treatments tools. This review summarises PDAC, downstream signalling pathways they in, how being used studied as therapeutic targets well prognostic/diagnostic improve clinical outcome PDAC.

Язык: Английский

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An Overview of the Role of MicroRNAs on Carcinogenesis: A Focus on Cell Cycle, Angiogenesis and Metastasis

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(8), С. 7268 - 7268

Опубликована: Апрель 14, 2023

In recent years, the importance of epigenetic markers in carcinogenesis different malignant neoplasms has been demonstrated, also demonstrating their utility for understanding metastatic spread and tumor progression cancer patients. Among biomarkers, microRNAs represent a set non-coding RNAs that regulate gene expression, having involved wide variety neoplasia acting oncogenic pathways. Both overexpression downregulation complex interaction with various genes whose ultimate consequence is increased cell proliferation, invasion driver markers. It should be noted current clinical practice, even though combination shown to useful by authors at diagnostic prognostic levels, there are no kits can used initial approach or assess recurrences oncological diseases. Previous works have cited as critical role several carcinogenic mechanisms, ranging from cycle alterations angiogenesis mechanisms distant dissemination. Indeed, specific seem tightly modulation components related these processes. For instance, cyclins cyclin-dependent kinases, transcription factors, signaling molecules angiogenic/antiangiogenic products, among others, recognized targets types cancer. Therefore, purpose this article describe main implications alterations, metastasis angiogenesis, trying summarize involvement carcinogenesis.

Язык: Английский

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The long non-coding RNA ZFAS1 promotes colorectal cancer progression via miR200b/ZEB1 axis

Pathology - Research and Practice, Год журнала: 2023, Номер 247, С. 154567 - 154567

Опубликована: Май 24, 2023

Язык: Английский

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Exploring the Key Signaling Pathways and ncRNAs in Colorectal Cancer

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(8), С. 4548 - 4548

Опубликована: Апрель 21, 2024

Colorectal cancer (CRC) is the third most prevalent to be diagnosed, and it has a substantial mortality rate. Despite numerous studies being conducted on CRC, remains significant health concern. The disease-free survival rates notably decrease as CRC progresses, emphasizing urgency for effective diagnostic therapeutic approaches. development caused by environmental factors, which mostly lead disruption of signaling pathways. Among these pathways, Wingless/Integrated (Wnt) pathway, Phosphatidylinositol 3-kinase/protein kinase B/mammalian target rapamycin (PI3K/AKT/mTOR) Mitogen-Activated Protein Kinase (MAPK) Transforming Growth Factor-β (TGF-β) p53 pathway are considered important. These pathways also regulated non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long (lncRNAs), circular (circRNAs). They have emerged crucial regulators gene expression in changing their levels. altered patterns ncRNAs been implicated progression development, suggesting potential targets. This review provides an overview five key regulation involved pathogenesis that studied identify promising avenues diagnosis treatment strategies.

Язык: Английский

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Non-coding RNAs, a double-edged sword in breast cancer prognosis

Cancer Cell International, Год журнала: 2025, Номер 25(1)

Опубликована: Апрель 1, 2025

Cancer is a rising issue worldwide, and numerous studies have focused on understanding the underlying reasons for its occurrence finding proper ways to defeat it. By applying technological advances, researchers are continuously uncovering updating treatments in cancer therapy. Their vast functions regulation of cell growth proliferation their significant role progression diseases, including cancer. This review provides comprehensive analysis ncRNAs breast cancer, focusing long non-coding RNAs such as HOTAIR, MALAT1, NEAT1, well microRNAs miR-21, miR-221/222, miR-155. These pivotal regulating proliferation, metastasis, drug resistance, apoptosis. Additionally, we discuss experimental approaches that useful studying them highlight advantages challenges each method. We then explain results these clinical trials offer insights future by discussing major existing gaps. On basis an extensive number studies, this valuable into potential Key findings show even though undeniable there still complications associated with therapeutic use. Moreover, absence sufficient experiments regarding application mouse models, which area work on. emphasizing crucial ncRNAs, underscores need innovative further explore

Язык: Английский

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Microfluidic Synthesis of miR-200c-3p Lipid Nanoparticles: Targeting ZEB2 to Alleviate Chondrocyte Damage in Osteoarthritis

International Journal of Nanomedicine, Год журнала: 2025, Номер Volume 20, С. 505 - 521

Опубликована: Янв. 1, 2025

Osteoarthritis (OA) is a degenerative joint disease characterized by articular cartilage degeneration. Chondrocyte inflammation, apoptosis, and extracellular matrix degradation accelerated OA progression. MicroRNA (miRNA) has the potential to be therapeutic method for osteoarthritis. However, it difficult penetrate cell exercise its biological function, effect unclear. lipo-AgPEI-miR-200c-3p was created combining miR-200c-3p with silver nitrate polyvinylimine nanoparticles on microfluidic device. The drug release curve, stability, temperature sensitivity, cytotoxicity, impact of expression proteins linked disintegration, inflammatory factors were all detected. Results showed that particle size Lipo-AgPEI-miR-200c-3p about 130 nm, Zeta lowered 1.08±0.12 mV. could increase viability, prevent decrease levels TNF-α, IL-6, IL-1β, MCP-1 in ADTC5 cells following LPS stimulation. MMP3, MMP13, ADAMTS-4 downregulated whereas collagen II upregulated. ZEB2 greatly elevated stimulation dramatically decreased transfection miR-200c-3p. Collagen rose si-ZEB2, factors, apoptosis-related proteins, decreased. dual luciferase experiment demonstrated target gene synergistic AgPEI can inhibit response, chondrocytes. also improve efficiency obtain good physicochemical properties drugs. may crucial development influence ZEB2, control chondrocyte breakdown.

Язык: Английский

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Urinary extracellular vesicles-encapsulated miRNA signatures: A new paradigm for urinary bladder cancer diagnosis and classification

Urologic Oncology Seminars and Original Investigations, Год журнала: 2024, Номер 42(7), С. 179 - 190

Опубликована: Апрель 8, 2024

Язык: Английский

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Circulating microRNAs for Early Diagnosis of Ovarian Cancer: A Systematic Review and Meta-Analysis

Biomolecules, Год журнала: 2023, Номер 13(5), С. 871 - 871

Опубликована: Май 22, 2023

In this study, we conducted a systematic review and meta-analysis to summarize evaluate the global research potential of different circulating miRNAs as an early diagnostic biomarker for OC. A literature search relevant studies was in June 2020 followed up November 2021. The English databases (PubMed, ScienceDirect). primary resulted total 1887 articles, which were screened according prior established inclusion exclusion criteria. We identified 44 studies, 22 eligible quantitative meta-analysis. Statistical analysis performed using Meta-package Rstudio. Standardized mean differences (SMD) relative levels between control subjects OC patients used differential expression. All quality evaluated Newcastle-Ottawa Scale. Based on meta-analysis, nine dysregulated compared controls. Nine upregulated controls (miR-21, -125, -141, -145, -205, -328, -200a, -200b, -200c). Furthermore, miR-26, -93, -106 -200a analyzed, but did not present overall significant difference These observations should be considered when performing future relation OC: sufficient size clinical cohorts, development consensus guidelines miRNA measurements, coverage previously reported miRNAs.

Язык: Английский

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E-cadherin re-expression: Its potential in combating TRAIL resistance and reversing epithelial-to-mesenchymal transition

Gene, Год журнала: 2024, Номер 909, С. 148293 - 148293

Опубликована: Фев. 17, 2024

The major limitation of conventional chemotherapy drugs is their lack specificity for cancer cells. As a selective apoptosis-inducing agent, tumor necrosis factor (TNF)-related ligand (TRAIL) has emerged as an attractive alternative. However, most the cells are found to be either intrinsically resistant TRAIL protein or may develop resistance after multiple treatments, and can induce epithelial-to-mesenchymal transition (EMT) at later stage, promoting invasion migration. Interestingly, E-cadherin loss been linked initiation EMT, making re-expression potential target overcome these obstacles. Recent research suggests that re-expressing reduce by enhancing TRAIL-induced apoptosis preventing EMT modulating signalling factors. This reversal also aid in improving apoptosis. Therefore, this review provides remarkable insights into mechanisms underlying re-expression, clinical implications, potentiation, well gaps current treatment.

Язык: Английский

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Understanding the role of miRNAs in cervical cancer pathogenesis and therapeutic responses

Frontiers in Cell and Developmental Biology, Год журнала: 2024, Номер 12

Опубликована: Авг. 28, 2024

Cervical cancer (CC) is the most common in women and poses a serious threat to health. Despite familiarity with factors affecting its etiology, initiation, progression, treatment strategies, even resistance therapy, it considered significant problem for women. However, several have greatly affected previous aspects of CC progression recent decades. miRNAs are short non-coding RNA sequences that regulate gene expression by inhibiting translation target mRNA. play crucial role pathogenesis promoting stem cell (CSC) proliferation, postponing apoptosis, continuing cycle, invasion, angiogenesis, metastasis. Similarly, influence important CC-related molecular pathways, such as PI3K/AKT/mTOR signaling pathway, Wnt/β-catenin system, JAK/STAT MAPK pathway. Moreover, affect response patients chemotherapy radiotherapy. Consequently, this review aims provide an acquainted summary onco tumor suppressor (TS) their potential therapy responses focusing on pathways drive them.

Язык: Английский

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