Anti-angiogenic therapy in head and neck squamous cell carcinoma - current limitations and future directions

Vessel Plus, Год журнала: 2024, Номер unknown

Опубликована: Июнь 24, 2024

Angiogenesis, the formation of new blood vessels, plays a crucial role in progression and metastasis various cancers, including head neck squamous cell carcinoma (HNSCC). HNSCCs are characterized by altered levels angiogenesis-related factors, overexpression pro-angiogenic factors such as vascular endothelial growth factor (VEGF) platelet-derived (PDGF), well dysregulation angiogenesis inhibitors. Together, these drive vessels within tumor microenvironment considered therapeutic targets HNSCC. Although preclinical studies promising, challenges have emerged clinical use anti-angiogenic agents clinic, treatment-related toxicities development resistance to therapy. There is an unmet need for further research elucidate molecular pathways involved HNSCC angiogenesis, identify novel targets, discover predictive biomarkers improve patient selection.

Язык: Английский

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Identification of key protein-coding genes, lncRNAs and their regulatory network associated with the progression of lung adenocarcinoma in humans

Human Gene, Год журнала: 2024, Номер unknown, С. 201368 - 201368

Опубликована: Дек. 1, 2024

Язык: Английский

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Shared molecular, cellular, and environmental hallmarks in cardiovascular disease and cancer: any place for drug repurposing?

Pharmacological Reviews, Год журнала: 2024, Номер 77(2), С. 100033 - 100033

Опубликована: Дек. 24, 2024

Cancer and cardiovascular disease (CVD) are the 2 biggest killers worldwide. Specific treatments have been developed for diseases. However, mutual therapeutic targets should be considered because of overlap cellular molecular mechanisms. research has grown at a fast pace, leading to an increasing number new mechanistic treatments. Some these drugs could prove useful treating CVD, which realizes concept cancer drug repurposing. This review provides comprehensive outline shared hallmarks primarily ischemic heart failure. We focus on chronic inflammation, altered immune response, stromal vascular cell activation, underlying signaling pathways causing pathological tissue remodeling. There is obvious scope targeting those mechanisms, thereby achieving reciprocal preventive benefits. Major attention devoted illustrating logic, advantages, challenges, viable examples repurposing discussing potential influence sex, gender, age, ethnicity in realizing this approach. Artificial intelligence will help refine personalized application patients with CVD. SIGNIFICANCE STATEMENT: (CVD), worldwide, share several So far, specific therapies tackle development slow compared drugs. Understanding intersection between mechanisms diseases basis therapeutics CVD treatment. approach allow rapid CVDs.

Язык: Английский

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Single-cell analysis identifies phospholysine phosphohistidine inorganic pyrophosphate phosphatase as a target in ulcerative colitis

World Journal of Gastroenterology, Год журнала: 2023, Номер 29(48), С. 6222 - 6234

Опубликована: Дек. 27, 2023

Ulcerative colitis (UC) is a chronic gastrointestinal disorder characterized by inflammation and ulceration, representing significant predisposition to colorectal cancer. Recent advances in single-cell RNA sequencing (scRNA-seq) technology offer promising avenue for dissecting the complex cellular inter-actions molecular signatures driving UC pathology.

Язык: Английский

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Single-cell transcriptomics reveals activation of endothelial cell and identifies LHPP as a potential target in ulcerative colitis

Heliyon, Год журнала: 2024, Номер 10(7), С. e29163 - e29163

Опубликована: Апрель 1, 2024

This study delves into Ulcerative colitis (UC), a persistent gastrointestinal disorder marked by inflammation and ulcers, significantly elevating colorectal cancer risk. The emergence of single-cell RNA sequencing (scRNA-seq) technology has opened new avenues for dissecting the intricate cellular dynamics molecular mechanisms at play in UC pathology. By analyzing scRNA-seq data from individuals with UC, our revealed consistent enhancement inflammatory response pathways throughout course disease, alongside detailing characteristics endothelial cell damage within environments. A noteworthy finding is downregulation Phospholysine Phosphohistidine Inorganic Pyrophosphate Phosphatase (LHPP), which exhibited inversely correlate STAT3 expression levels. markedly reduced LHPP both tissues plasma patients positions as compelling target therapeutic intervention. Our findings highlight pivotal role could moderating inflammation, spotlighting its potential crucial quest to understand treat UC.

Язык: Английский

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Expression of Interleukin-8, Interleukin-12 and Interleukin-13 in Esophageal Squamous Cell Carcinoma: Biomarker Potentiality and Prognostic Significance

Journal of Gastrointestinal Cancer, Год журнала: 2024, Номер 55(3), С. 1239 - 1255

Опубликована: Июнь 23, 2024

Язык: Английский

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