Advances in Clinical Medicine, Год журнала: 2023, Номер 13(08), С. 13561 - 13566
Опубликована: Янв. 1, 2023
Язык: Английский
Journal of Experimental & Clinical Cancer Research, Год журнала: 2025, Номер 44(1)
Опубликована: Янв. 11, 2025
Abstract Background Adenoid cystic carcinoma (ACC) is a rare glandular malignancy, commonly originating in salivary glands of the head and neck. Given its protracted growth, ACC usually diagnosed advanced stage. Treatment limited to surgery and/or adjuvant radiotherapy, which often fails prevent disease recurrence, no FDA-approved targeted therapies are currently available. As such, identification new therapeutic targets specific crucial for improved patients’ outcomes. Methods After thoroughly evaluating gene expression signaling patterns characterizing ACC, we applied PandaOmics (an AI-driven software platform novel target discovery) on unique transcriptomic dataset 87 primary ACCs. Identifying protein arginine methyl transferase 5 (PRMT5) as putative candidate with top-scored druggability, next determined applicability PRMT5 inhibitors (PRT543 PRT811) using cell lines, organoids, patient derived xenograft (PDX) models. Molecular changes associated response inhibition anti-proliferative effect combination therapy lenvatinib was then analyzed. Results Using comprehensive AI-powered engine identification, predicted among potential candidates ACC. Here show that monotherapy selective induced potent anti-tumor activity across several cellular animal models paralleled by downregulation genes tumorigenesis, including MYB MYC (the recognized drivers progression). Furthermore, subset upregulated demonstrate addition enhanced growth inhibitory blockade vitro, suggesting clinical benefit patients expressing favorable molecular profile. Conclusion Taken together, our study underscores role oncogenesis provides strong rationale development or treatment this disease, based analysis their underlying
Язык: Английский
Процитировано
0
Human Pathology, Год журнала: 2025, Номер unknown, С. 105758 - 105758
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Clinica Chimica Acta, Год журнала: 2025, Номер unknown, С. 120258 - 120258
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Contemporary Diagnostic Radiology, Год журнала: 2025, Номер 48(9), С. 1 - 7
Опубликована: Март 23, 2025
Adenoid cystic carcinoma (ACC) is a rare malignancy predominantly originating in the salivary glands, but capable of emerging other secretory-gland-rich anatomical sites, including reproductive tract, trachea, esophagus, and skin. Although characterized by its slow growth, ACC notably has concerning propensity for perineural spread often associated with late distant metastasis. Diagnosis management are complicated nonspecific presentation indolent nature. CT scan MR imaging offer insights into local extent ACC, highlighting features such as invasion involvement. Functional PET/CT emerged pivotal both initial staging detecting recurrence. This review underscores integral role multimodality imaging, especially PET/CT, improved clinical assessment optimization treatment strategies.
Язык: Английский
Процитировано
0
Genes, Год журнала: 2025, Номер 16(4), С. 370 - 370
Опубликована: Март 24, 2025
Background/Objectives: Salivary adenoid cystic carcinoma (ACC) is a rare but aggressive neoplasm that predominantly arises from the salivary glands, accounting for significant proportion of gland cancers. The aim this literature review to illustrate current insights on ACC with regards related genes and molecular pathways by analyzing original research articles period 2015–2025. Methods: An electronic search was performed between January February 2025 identify all investigating its pathways. conducted using MEDLINE (National Library Medicine)-PubMed restrictions concerning date publication. In particular, we focused 2015–2025 following keywords: AND This followed manual search, references were used relevant articles. Results: total, 41 identified through keywords. After implementation time frame 2015–2025, 31 remained. Subsequently, reading titles abstracts thereby excluding non-original written in language other than English, 23 Conclusions: These studies or whose analysis yielded most recent data regarding their function. classification multifaceted, encompassing distinct histological subtypes are crucial determining prognosis treatment approaches. Current oncological practices classify based these features alongside emerging genetic markers promise enhance our understanding disease’s biology. Diagnostic strategies have evolved, leveraging techniques such as biopsy diagnostics, which significantly improved detection characterization ACC. Regarding treatment, management remains challenge due propensity local invasion metastasis, surgery, radiation, chemotherapy being mainstays therapy. development targeted therapies ACC’s profile will allow better an enhanced quality life patients.
Язык: Английский
Процитировано
0
Oral Surgery Oral Medicine Oral Pathology and Oral Radiology, Год журнала: 2024, Номер 138(6), С. 772 - 780
Опубликована: Авг. 16, 2024
Язык: Английский
Процитировано
2
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(14), С. 11370 - 11370
Опубликована: Июль 12, 2023
Primary tracheal tumors are rare, constituting approximately 0.1-0.4% of malignant diseases. Squamous cell carcinoma (SCC) and adenoid cystic (ACC) account for about two-thirds these tumors. Despite most primary cancers being eligible surgery and/or radiotherapy, unresectable, recurrent metastatic may require systemic treatments. Unfortunately, the poor response to available chemotherapy as well lack other real therapeutic alternatives affects quality life outcome patients suffering from more advanced disease. In this condition, target therapy against driver mutations could constitute an alternative chemotherapy, help in disease control. The past two decades have seen extraordinary progress developing novel treatment options, shifting paradigm several such lung cancer. improvement knowledge regarding genetic biological alterations, major tumors, has opened up new perspectives, suggesting possible role targeted therapies rare purpose review is outline state molecular biology, preliminary data on treatments main focusing salivary-gland-derived squamous carcinoma.
Язык: Английский
Процитировано
5
Research Square (Research Square), Год журнала: 2024, Номер unknown
Опубликована: Март 7, 2024
Abstract Background adenoid cystic carcinoma (ACC), a rare malignancy often treated through multidisciplinary approach, is noted for its slow progression and aggressive behavior. This study focuses on the impact of histone modification drugs (HMD) ACC tumors implications treatment. Methods: by analyzing effects HMD Cancer Stem Cells (CSC) non-CSC tumor cells, we investigated inhibitory effect various histone-modifying compounds cells. Our dual-pronged approach used reductions in sphere size increased cell death as indicators drug efficacy, employing diverse targeting histones. Results: subsequent validation revealed promising results, with specific showing significant cytotoxicity. Moreover, several as-yet untried clinical trials showed potential, notably UNC0638, methyltransferase inhibitor, ITF2357 (Givinostat), an HDAC inhibitor that exhibited significantly high cell-death percentages. Also examined was application distinct to non-cancer stem cells within tumors. Conclusions: findings underline importance identifying capable CSC independently from both populations present contrasting sensitivities.
Язык: Английский
Процитировано
1
International Journal of Ophthalmology, Год журнала: 2023, Номер 17(1), С. 164 - 172
Опубликована: Дек. 25, 2023
To evaluate lacrimal gland adenoid cystic carcinoma (LGACC) of prognosis in patients who underwent different treatment regimens.
Язык: Английский
Процитировано
3
Cancer Diagnosis & Prognosis, Год журнала: 2024, Номер 4(1), С. 25 - 29
Опубликована: Янв. 2, 2024
Among the tumour suppressor genes that affect critically cell functions and homeostasis, phosphatase tensin homolog deleted in chromosome 10 (PTEN- gene locus: 10q21) regulates PI3K/Akt/mTOR signalling pathway. PTEN is deleted, mutated or epigenetically hyper-methylated a variety of human solid malignancies. Salivary gland carcinomas (SGCs) belong to head neck (HNCs) super category Histo-pathologically, they demonstrate significant diversity due distinct mixed subtypes. Genetically, are characterized by broad spectrum chromosomal imbalances. Referring specifically genes, deregulation plays critical role signaling transduction corresponding SGC pre- malignant epithelia modifying response rates potential targeted therapeutic strategies. In current review, we explored mechanisms involved onset progression SGCs.
Язык: Английский
Процитировано
0