Cross-talk between cuproptosis and ferroptosis to identify immune landscape in cervical cancer for mRNA vaccines development DOI Creative Commons

Xuchao Zhang,

Wenwen Xu,

Zi Wang

и другие.

European journal of medical research, Год журнала: 2024, Номер 29(1)

Опубликована: Дек. 19, 2024

Messenger RNA (mRNA)-based vaccines present a promising avenue for cancer immunotherapy; however, their application in cervical remains unexplored. This study investigated the interplay between regulated cell death pathways of cuproptosis and ferroptosis to advance development mRNA cancer. We identified key cuproptosis-related ferroptosis-related genes (CFRGs) from public profiles determined prognostic significance, mutation frequencies, effect on immune landscape. Our analysis revealed two distinct subtypes associated with CFRGs, differences prognosis characteristics. Using LASSO, XGBoost, SVM–RFE methods, we established 4-gene signature (TSC22D3, SQLE, ZNF419, TFRC) stratify patients based risk determine its correlation microenvironment, profiles, treatment responses. RT-qPCR validation confirmed differential expression these clinical samples. findings identify TSC22D3, TFRC as candidate targets vaccine offer potential tool personalized treatment.

Язык: Английский

Copper, Iron, Cadmium, and Arsenic, All Generated in the Universe: Elucidating Their Environmental Impact Risk on Human Health Including Clinical Liver Injury DOI Open Access
Rolf Teschke

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(12), С. 6662 - 6662

Опубликована: Июнь 17, 2024

Humans are continuously exposed to various heavy metals including copper, iron, cadmium, and arsenic, which were specifically selected for the current analysis because they among most frequently encountered environmental mankind industrial pollutants potentially causing human health hazards liver injury. So far, these issues poorly assessed remained a matter of debate, also due inconsistent results. The aim actual report is thoroughly analyze positive as well negative effects four on health. Copper iron correctly viewed pollutant elements essential maintaining part important enzymes metabolic pathways. Healthy individuals prepared through genetically based mechanisms maintain cellular copper homeostasis, thereby circumventing or reducing hazardous organ injury excessive amounts entering body. In few humans with gene aberration, however, may develop excessively accumulated can lead Wilson disease substantial deposition hemochromatosis. At molecular level, toxicities some traced back Haber Weiss Fenton reactions involving reactive oxygen species formed in course oxidative stress. On other hand, homeostasis cadmium arsenic cannot be provided, their life-long organs. Consequently, represent leading higher disability-adjusted life years increased mortality rates cancer non-cancer diseases. For unknown reasons, rarely observed. sum, good except those hemochromatosis at risk radical formation, while lack any beneficial but rather focus disability potential cancer. Primary efforts should emission metals.

Язык: Английский

Процитировано

22
The Role of Copper Ions in Mediating the Anti‐Cancer Effects Using Nanomaterials DOI Open Access

Irfan Mehmud,

Song Wu, Shaohua Zhang

и другие.

Advanced Therapeutics, Год журнала: 2025, Номер unknown

Опубликована: Фев. 3, 2025

Abstract Copper plays a pivotal role in human physiology, particularly oncology, acting both as facilitator of progression and also potential avenue for advanced therapeutic approaches. Maintaining copper homeostasis is crucial. The dysregulation implicated tumor growth through its involvement critical processes angiogenesis, proliferation, metastasis. elevation level the microenvironment (TME) activates oncogenic pathways to drive neovascularization sustained malignancies. However, same reliance on offers unique weakness that can be leveraged innovative interventions. recent advances nanomedicine enable synthesis nanostructures help modulate with precision offering multifaceted approaches copper‐based cancer therapy controlled release mechanism, optimized structures induce cuproptosis, selective eradication cells minimum systemic toxicity. This review explores dual biology, emphasizing contribution tumors emerging application targeted therapy. highlights harnessing therapies their transformative from bench bed side novel, highly effective, clinical safety.

Язык: Английский

Процитировано

1
Taxifolin regulates SLC31A1-mediated cuproptosis and tumor progression in hepatocellular carcinoma DOI
Jike Li,

Yuelian Wang,

Lei Bao

и другие.

Human Cell, Год журнала: 2025, Номер 38(2)

Опубликована: Янв. 3, 2025

Язык: Английский

Процитировано

1
The functions of cuproptosis in gastric cancer: therapy, diagnosis, prognosis DOI Open Access
Zhiqin Zhang,

Shenhua Shao,

Hao Luo

и другие.

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 177, С. 117100 - 117100

Опубликована: Июль 15, 2024

Gastric cancer (GC) is the fifth most prevalent type of in whole world. Cuproptosis discovered as a programmed cell death pathway and connected to cells' growth death, well tumorigenesis. The relationship between cuproptosis GC still elusive. Two aspects this study will elaborate immunotherapy biomarkers GC. Notably, herein review intended highlight what has been accomplished regarding for diagnosis, immunotherapy, prognosis aim offer potential directions strategies future research inside

Язык: Английский

Процитировано

4
The Molecular Mechanisms of Cuproptosis and Small-Molecule Drug Design in Diabetes Mellitus DOI Creative Commons

Zhao-Wen Pan,

Lan Huang,

Yuanyuan Gan

и другие.

Molecules, Год журнала: 2024, Номер 29(12), С. 2852 - 2852

Опубликована: Июнь 15, 2024

In the field of human health research, homeostasis copper (Cu) is receiving increased attention due to its connection pathological conditions, including diabetes mellitus (DM). Recent studies have demonstrated that proteins associated with Cu homeostasis, such as ATOX1, FDX1, ATP7A, ATPB, SLC31A1, p53, and UPS, also contribute DM. Cuproptosis, characterized by dysregulation overload, has been found cause oligomerization lipoylated in mitochondria, loss iron–sulfur protein, depletion glutathione, production reactive oxygen species, cell death. Further research into how cuproptosis affects DM essential uncover mechanism action identify effective interventions. this article, we review molecular role pathogenesis The study small-molecule drugs affect these offers possibility moving from symptomatic treatment treating underlying causes

Язык: Английский

Процитировано

3
A Narrative Review of Prognostic Gene Signatures in Oral Squamous Cell Carcinoma Using LASSO Cox Regression DOI Creative Commons

Nur Fatinazwa Mohd Faizal,

Saptarsi Shai,

Bansi Savaliya

и другие.

Biomedicines, Год журнала: 2025, Номер 13(1), С. 134 - 134

Опубликована: Янв. 8, 2025

Oral squamous cell carcinoma (OSCC) is one of the most common malignancies head and neck (HNSCC). HNSCC recognized as eighth commonly occurring cancer globally in men. It essential to distinguish between cancers arising regions due significant differences their etiologies, treatment approaches, prognoses. As Cancer Genome Atlas (TCGA) dataset available HNSCC, survival analysis prognosis OSCC patients based on TCGA for discovering gene expression-based prognostic biomarkers limited. To address this paucity, we aimed provide comprehensive evidence by recruiting studies that have reported new biomarkers/signatures establish a model predict patients. Using PubMed search, identified 34 been using least absolute shrinkage selection operator (LASSO)-based Cox regression analyses signature related different pathways from past 4 years. Our review was focused summarizing these signatures implications targeted therapy FDA-approved drugs. Furthermore, conducted an LASSO signatures. findings revealed 13 correlated greater number regulatory T cells (Tregs) protective with increased recurrence-free overall rates. Conversely, two displayed opposing trend cases OSCC. We will also explore how dysregulation impacts immune status, promoting tumor evasion or, conversely, enhancing surveillance. Overall, insight future anti-cancer therapies potential associated poor

Язык: Английский

Процитировано

0
Impact of cuproptosis in gliomas pathogenesis with targeting options DOI

Mariam Markouli,

Panagiotis Skouras, Christina Piperi

и другие.

Chemico-Biological Interactions, Год журнала: 2025, Номер unknown, С. 111394 - 111394

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Group IB Metal‐Based Nanomaterials for Antibacterial Applications DOI Creative Commons

Xuezhi Zhao,

Hongyu Wang, Yun Sun

и другие.

Small Science, Год журнала: 2025, Номер unknown

Опубликована: Март 9, 2025

Pathogenic bacteria pose significant threats to human health. In recent years, escalating bacterial resistance against antibiotics has diminished their efficacy in treating infections like pneumonia, tuberculosis, and sepsis, making some cases virtually untreatable. Hence, there is an urgent demand for novel approaches combat threats. Group IB metal‐based nanomaterials including copper, silver, gold have attracted considerable attention the field of antibacterial research owing remarkable broad‐spectrum bactericidal properties. Their high efficacy, ease synthesis, amenability functionalization render group highly promising diverse applications domain. This review comprehensively elucidates on mechanisms IB‐group addressing infections. Additionally, insights into challenges associated with utilizing such purposes while outlining future directions are provided.

Язык: Английский

Процитировано

0
Cuproptosis-related genes and agents: implications in tumor drug resistance and future perspectives DOI Creative Commons

Lingwen Xu,

Xiaolan Cao,

Yuxiao Deng

и другие.

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Май 8, 2025

In the field of tumor treatment, drug resistance remains a significant challenge requiring urgent intervention. Recent developments in cell death research have highlighted cuproptosis, mechanism induced by copper, as promising avenue for understanding biology and addressing resistance. Cuproptosis is initiated dysregulation copper homeostasis, which turn triggers mitochondrial metabolic disruptions induces proteotoxic stress. This process specifically entails accumulation lipoylated proteins depletion iron-sulfur cluster within context tricarboxylic acid cycle. Simultaneously, it accompanied activation distinct signaling pathways that collectively lead to death. Emerging evidence highlights critical role cuproptosis However, core molecular mechanisms regulation microenvironment, clinical translation still require further exploration. review examines intersection resistance, detailing essential roles cuproptosis-related genes exploring therapeutic potential ionophores, chelators, nanodelivery systems. These offer promise overcoming advancing precision medicine. By elucidating underlying this study aims identify novel strategies targets, thereby paving way development innovative anti-cancer drugs.

Язык: Английский

Процитировано

0
Mechanism of cell death and its application in the repair of inflammatory bowel disease by mesenchymal stem cells DOI Creative Commons

Francis Atim Akanyibah,

C. He,

Peipei Cai

и другие.

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Июнь 4, 2025

The onset and progression of inflammatory bowel disease (IBD), which encompasses ulcerative colitis Crohn’s disease, are influenced by the immune system, environmental factors, genetics, intestinal flora. Cell death is a biological phenomenon that occurs in all living organisms; nevertheless, excessive cell has been linked to IBD, including increased epithelial barrier abnormalities. Anti-tumor necrosis factor medication, made significant progress treating IBD death, may fail some individuals or lose effectiveness over time, necessitating search for safe effective treatment. One novel emerging areas regenerative nanomedicine used regulate mesenchymal stem cells (MSCs) their mediators (extracellular vesicles). MSCs have found attenuate several illnesses, IBD. This review explores mechanisms implications focusing on potential ameliorative effects death.

Язык: Английский

Процитировано

0