STAT3-related lncRNAs in colorectal cancer progression; special focus on immune cell’s evasion

Pathology - Research and Practice, Год журнала: 2025, Номер 266, С. 155810 - 155810

Опубликована: Янв. 5, 2025

Язык: Английский

GAS5 rs145204276 Ins/Del Polymorphism Is Associated with CRC Susceptibility in a Romanian Population

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(7), С. 3078 - 3078

Опубликована: Март 27, 2025

Colorectal cancer (CRC) is a leading cause of cancer-related morbidity and mortality, influenced by both genetic epigenetic factors. Long non-coding RNAs (lncRNAs) such as GAS5 CASC8 have been implicated in susceptibility. This study aimed to assess the association rs145204276 ins/del rs10505477 A>G polymorphisms with CRC risk Romanian population. A case-control was conducted, including 156 patients 195 healthy controls. Genotyping for performed using real-time PCR, evaluated logistic regression calculate odds ratios (OR) 95% confidence intervals (CI). The carriers del allele significantly associated increased (OR: 2.13, CI: 1.24-3.63, p = 0.005) dominant model. In subgroup analysis, polymorphism restricted distal colon cases 2.98, 1.57-5.66, 0.001), advanced tumor stages (III + IV) 2.54, 1.31-4.91, 0.007), poorly differentiated tumors (G3) 3.98, 1.49-10.59, 0.009). No significant correlation found polymorphism. may influence susceptibility, particularly stages. However, showed no this cohort.

Язык: Английский

The SOX gene superfamily in oncogenesis: unraveling links to ncRNAs, key pathways, chemoresistance, and gene editing approaches

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2025, Номер unknown

Опубликована: Май 20, 2025

Язык: Английский