Molecular mechanisms and therapeutic strategies in overcoming chemotherapy resistance in cancer
Molecular Biomedicine,
Год журнала:
2025,
Номер
6(1)
Опубликована: Янв. 6, 2025
Cancer
remains
a
leading
cause
of
mortality
globally
and
major
health
burden,
with
chemotherapy
often
serving
as
the
primary
therapeutic
option
for
patients
advanced-stage
disease,
partially
compensating
limitations
non-curative
treatments.
However,
emergence
resistance
significantly
limits
its
efficacy,
posing
clinical
challenge.
Moreover,
heterogeneity
mechanisms
across
cancer
types
complicates
development
universally
effective
diagnostic
approaches.
Understanding
molecular
chemoresistance
identifying
strategies
to
overcome
it
are
current
research
focal
points.
This
review
provides
comprehensive
analysis
key
underlying
resistance,
including
drug
efflux,
enhanced
DNA
damage
repair
(DDR),
apoptosis
evasion,
epigenetic
modifications,
altered
intracellular
metabolism,
role
stem
cells
(CSCs).
We
also
examine
specific
causes
in
highlight
various
targets
involved
resistance.
Finally,
we
discuss
aiming
at
overcoming
such
combination
therapies,
targeted
treatments,
novel
delivery
systems,
while
proposing
future
directions
this
evolving
field.
By
addressing
these
barriers,
lays
foundation
more
therapies
aimed
mitigating
Язык: Английский
Management of lung cancer in older adults
Zeitschrift für Gerontologie und Geriatrie,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 19, 2025
Язык: Английский
Exploring manzamine a: a promising anti-lung cancer agent from marine sponge Haliclona sp
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Фев. 25, 2025
Manzamine
A
(MA),
a
bioactive
compound
derived
from
the
marine
sponge
Haliclona
sp.,
shows
considerable
therapeutic
potential,
particularly
in
treatment
of
various
cancer
types.
Extracted
with
acetone
and
purified
through
chromatography,
MA
exhibits
bioavailability
20.6%
when
administered
orally
rats,
underscoring
its
feasibility
for
use.
This
disrupts
key
cellular
mechanisms
essential
progression,
including
microtubule
dynamics
DNA
replication
enzymes,
demonstrating
strong
anti-proliferative
effects
against
multiple
cell
lines
while
sparing
normal
cells.
Additionally,
network
pharmacology
molecular
docking
studies
reveal
MA's
interactions
important
targets
related
to
lung
such
as
EGFR
SRC,
bolstering
potential
novel
anti-lung
agent.
Pathway
analyses
further
indicate
that
influences
critical
signaling
pathways
involved
tumor
growth
metastasis.
Given
urgent
need
effective
treatments
drug-resistant
cancers
limited
toxicity
profile
MA,
exploration
pharmacological
benefits
mechanism
could
pave
way
new
strategies
cancer.
Язык: Английский
Current diagnostic and therapeutical approaches to bone metastases in patients with non-small cell lung cancer: A cross-sectional study
Lung Cancer,
Год журнала:
2025,
Номер
unknown, С. 108531 - 108531
Опубликована: Апрель 1, 2025
The
current
study
aims
to
investigate
the
practice
of
bone
metastasis
management
in
patients
with
non-small
cell
lung
cancer.
An
online
questionnaire
was
administered
92
oncologists.
A
survey
developed
and
revised
by
dedicated
experts
composed
five
sections:
i)
general
work
characteristics,
ii)
diagnostic
issues,
bone-targeted
agents
iii)
radiotherapy
iv)
supportive
care
issues.
Descriptive
statistics
applied.
18F-FDG
PET
is
preferred
evaluation
for
skeletal
assessment
both
(62
%)
without
(54
lesions
at
CT
scan;
MRI
(63
(61
are
most
chosen
radiographic
assessments
when
a
oligoprogression
suspected.
number
metastatic
main
factor
considered
deciding
whether
start
(57
%).
In
choosing
between
agents,
renal
toxicity
Over
half
participants
did
not
stop
systemic
treatment
during
stereotactic
(68
re-irradiation
on
progressive
metastases
least
6
months
after
prior
(55
Overall,
64
%
41
assessed
patients'
body
weight
physical
activity,
respectively.
Oral
nutritional
supplements
or
specific
diet
were
recommended
34
46
clinicians;
40
them
also
advised
their
increase
activity
levels,
while
54
worried
that
exercise
might
risk
skeletal-related
adverse
events.
Lung-cancer
clinicians
pay
great
attention
metastases-related
diagnostic,
whereas
integration
approaches
seem
less
standardized.
Язык: Английский
A newly constructed STC2/FPR1 dual genes signature works as a prognosis risk indicator with implication in the macrophages dominated and TIM-3 checkpoint related osteosarcoma immune landscape
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 17, 2024
Abstract
Background
Osteosarcoma
has
been
a
common
bone
malignancy
occurring
in
children
and
adolescents.
Attributing
to
high
tumor
heterogeneity,
none
specific
breakthrough
received
targeted
gene
therapy
for
osteosarcoma,
although
it’s
still
of
great
potential
immunotherapy
clinical
application.
In
the
study,
5
GEO
profiles
containing
transcriptome
information
109
osteosarcoma
samples,
single
cell
sequencing
data
composed
6
cases
as
well
43
local
hospital
tissue
samples
were
combine
used
identify
promising
immune
related
candidate
genes
osteosarcoma.
Methods
Based
on
microarrays
from
database
profile
IMMPORT
database,
differently
expressed
meanwhile
candidates
comparing
normal
control
identified.
Then,
protein-protein
interaction
network
(PPI),
survival
analysis
followed
by
LASSO
succession
applied
construct
signature
based
selected
genes.
After
understanding
basic
genetic
physicochemical
properties
evaluating
prognosis
risk
association
using
cancer
its
with
microenvironment
features
including
macrophages
included
various
cells
infiltration,
different
checkpoints
expression,
signaling
pathways
involvement
next
step
assessed.
Results
From
datasets
which
contains
total
108
level
PPI
highlighted
cluster
Further,
ROC
curve
Cox
regression
assisted
scaled
hub
down
2
key
genes,
namely
STC2
FPR1,
was
constructed
them.
double
staining
immunochemistry
(IHC)
experiment
date
revealed
that
mainly
cells,
meanwhile,
FPR1
mostly
enriched
focused
also
main
type
microenvironment.
Moreover,
combining
STC2/FPR1
dual
associated
distribution
multiple
checkpoints,
especially
TIM-3.
correlation
between
other
death
(ICD)
ESTIMATE
score
additionally
evaluated.
Conclusions
analysis,
constructed.
Immune
indicated
infiltration
ans
it
TIM-3
expression.
The
results
shall
benefit
further
researches
assist
revealing
prediction
markers
immunotherapy.
Язык: Английский
A prognostic nomogram of non-small cell lung cancer based on tumor marker inflammatory nutrition score
Translational Lung Cancer Research,
Год журнала:
2024,
Номер
13(12), С. 3392 - 3406
Опубликована: Дек. 1, 2024
Patients
diagnosed
with
non-small
cell
lung
cancer
(NSCLC)
usually
have
a
poor
prognosis,
so
it
is
critical
to
identify
effective
biomarkers
for
prognosis
prediction.
The
aim
of
this
study
establish
nomogram
evaluate
the
prognostic
significance
blood
markers
in
patients
NSCLC
and
provide
reference
clinical
work.
A
total
486
who
were
admitted
hospital
from
January
2009
December
2019
retrospectively
analyzed.
cohort
was
divided
into
training
set
(n=340)
validation
(n=146).
Eleven
indicators
selected
as
parameters
by
least
absolute
shrinkage
selection
operator
(LASSO)
model
tumor
marker
inflammatory
nutrition
(TMIN)
score.
Univariate
multivariate
regression
analyses
performed
TMIN-nomogram
predicting
overall
survival
(OS)
progression-free
(PFS).
Receiver
operating
characteristic
(ROC)
curve,
calibration
curve
decision
analysis
(DCA)
used
predictive
performance
model.
TMIN
score
constructed
11
most
valuable
variables,
including
white
cells
(WBCs),
neutrophils
(N),
platelets
(PLT),
albumin
(ALB),
globulin
(GLB),
prealbumin
(PAB),
carcinoembryonic
antigen
(CEA),
cytokeratin
fragment
21-1
(CYFRA21-1),
fibrinogen
(FIB),
platelet/lymphocyte
ratio
(PLR),
lymphocyte/monocyte
(LMR),
low-risk
high-risk
groups
using
optimal
cutovers.
showed
good
value
both
OS
PFS.
In
addition,
sex,
smoke,
pathological
classification,
American
Joint
Committee
on
Cancer
stage
(AJCC
stage),
diameter
Eastern
Cooperative
Oncology
Group-performance
status
(ECOG-PS)
other
strong
correlation.
confirmed
that
an
independent
risk
factor
PFS
patients.
It
worth
noting
based
combined
has
very
promising
predictor
prediction
can
be
tool
comprehensive
evaluation
Язык: Английский