The FUS/COL11A1/ZEB1 Axis Contributes to the Development of Oral Squamous Cell Carcinoma
Journal of Oral Pathology and Medicine,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 6, 2025
Oral
squamous
cell
carcinoma
(OSCC)
is
a
common
type
of
head
and
neck
cancer
with
high
metastasis
rate
poor
prognosis.
This
study
aimed
to
explore
the
role
collagen
XI
alpha
1
(COL11A1)
its
detailed
mechanisms
in
OSCC
progression.
Quantitative
reverse
transcription
polymerase
chain
reaction
(RT-qPCR)
analysis
was
used
measure
level
COL11A1,
fused
sarcoma/translocated
liposarcoma
(FUS)
zinc
finger
E-box
binding
homeobox
(ZEB1).
The
protein
expression
E-cadherin,
N-cadherin,
FUS,
ZEB1
were
detected
using
Western
blot.
3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium
bromide
(MTT)
5-Ethynyl-2'-deoxyuridine
(EdU)
staining
assays
conducted
proliferation.
Cell
migration
invasion
evaluated
via
wound-healing
assay
transwell
assays,
respectively.
Moreover,
epithelial
mesenchymal
transition
(EMT)
determined
detecting
EMT-related
proteins,
including
E-cadherin
N-cadherin.
RNA
immunoprecipitation
evaluate
relationship
between
COL11A1.
In
vivo
animal
experiments
carried
out
COL11A1
mice,
immunohistochemistry
performed
detect
proteins
tumor
tissues
from
mice.
augmented
cells.
knockdown
significantly
inhibited
proliferation,
migration,
invasion,
EMT
FUS
increased
tissues.
stabilized
mRNA
positively
regulated
highly
expressed
tissues,
COL11A1directly
targeted
ZEB1.
inhibition
effects
on
reversed
by
overexpression
Additionally,
depletion
markedly
repressed
growth
through
decreasing
vivo.
promote
malignant
progression
regulating
expression.
Язык: Английский
Understanding and treating HPV-associated oropharyngeal carcinoma: insights from a MedNewsWeek Keynote lecture by Dr Theodoros N. Teknos and literature review
Therapeutic Advances in Medical Oncology,
Год журнала:
2025,
Номер
17
Опубликована: Янв. 1, 2025
Oropharyngeal
carcinoma,
a
type
of
head
and
neck
cancer
(HNC),
is
an
emerging
malignancy
associated
with
low
survival
rates.
It
typically
affects
older
males
correlates
smoking,
drinking,
lower
socioeconomic
conditions.
Traditional
treatments
such
as
surgery
have
often
yielded
limited
outcomes.
However,
recent
insights,
particularly
those
emphasized
by
Dr
Teknos
in
his
Keynote
Conference
at
MedNews
Week,
sparked
deeper
exploration
into
alternative
more
promising
treatment
methods.
A
comprehensive
literature
review
was
conducted
to
explore
this
subject
further.
One
approach,
demonstrated
the
UMCC
9921
trial,
involves
protocol
starting
induction
chemotherapy.
This
initial
phase
aims
reduce
tumor
burden
assess
response
treatment.
Based
on
individual
outcomes,
patients
then
undergo
concurrent
chemoradiation
or
salvage
surgery.
strategy
has
significantly
improved
rates,
especially
human
papillomavirus
(HPV)-positive
patients,
showcasing
potential
tailored
treatments.
While
these
advancements
are
promising,
long-term
complications
dysphagia
osteoradionecrosis
remain
cause
concern.
The
rise
HPV-related
squamous
cell
carcinoma
further
changed
how
risk
factors
outcomes
viewed.
HPV-positive
cancers
unique
characteristics
respond
well
modern
therapies.
Researchers
investigating
biomarkers
circulating
HPV
DNA
immunoglobulin
J
polypeptide
expression,
which
could
provide
valuable
insights
disease
progression
pave
way
for
targeted
effective
strategies.
In
addition,
use
existing
medications,
fenofibrate,
combat
infections
illustrates
resourcefulness
repurposing
specific
Challenges
persist,
need
reliable
early
detection
monitoring.
Deeper
viral-host
interactions
shape
immunotherapy
strategies
that
revolutionize
approaches.
Collaborative
efforts
between
researchers,
healthcare
providers,
policymakers
play
vital
role
translating
substantial
clinical
benefits,
improving
quality
life
individuals
affected
diseases.
HPV-associated
HNCs
present
significant
challenges,
continuous
research
innovative
offer
hope
brighter
future
combating
growing
epidemic
patient
care.
Язык: Английский
Expression of 9-O-Acetylated Sialic Acid in HPV+ Oral Squamous Cell Carcinoma Cells
Hugo Sánchez-Martínez,
Victoria Jiménez-Castillo,
Daniela Illescas-Barbosa
и другие.
Life,
Год журнала:
2025,
Номер
15(4), С. 663 - 663
Опубликована: Апрель 17, 2025
Oral
squamous
cell
carcinoma
(OSCC)
is
a
common
type
of
head
and
neck
malignancy
that
represents
significant
global
health
issue.
Sialylations
are
events
in
tumor
transformation,
proliferation,
metastasis,
immune
evasion.
Modifications
sialylation
can
be
detected
by
lectins,
whose
changes
OSCC
have
been
related
to
grade,
invasion,
metastasis.
The
presence
9-O-acetylated
sialic
acid
(Neu5,9Ac2)
cells
its
potential
expression,
modification,
role
unknown.
This
study
aimed
analyze
the
expression
Neu5,9Ac2
using
Macrobrachium
rosenbergii
lectin
(MrL)
recognizes
this
(Neu5Ac)
residue
also
compare
effect
on
SCC-152
line
(CRL-3240,
ATCC)
immortalized
keratinocytes
(HaCaT)
as
control.
We
observed
immunocytochemistry
expressed
more
compared
HaCaT
cells;
specificity
MrL
was
confirmed
after
sialidase
treatment
which
loss
lectin’s
recognition
observed.
electrophoretic
profile
similar
between
both
types;
however,
Western
blot
showed
differences
glycoprotein
patterns
recognized
for
each
type.
increased
proliferation
cells,
well
integrity
morphology
colonies.
Therefore,
our
results
suggest
glycosylated
receptors
could
involved
survival
offers
promising
avenue
developing
diagnostic
prognostic
tools
(tumor
markers)
against
oral
future.
Язык: Английский
Head and neck cancer trends in Ohio: Examining temporal, anatomical, and geospatial patterns across Appalachian and non-Appalachian regions
American Journal of Otolaryngology,
Год журнала:
2025,
Номер
unknown, С. 104634 - 104634
Опубликована: Апрель 1, 2025
Head
and
neck
cancer
(HNC)
is
the
seventh
most
common
type
of
worldwide.
Compared
to
rest
United
States,
Appalachia
has
higher
incidence
rates
HNC.
The
purpose
this
project
examine
temporal,
anatomical,
geospatial
variances
in
head
cancers
across
Ohio,
focusing
on
disparities
between
Appalachian
non-Appalachian
regions.
Data
was
sourced
from
Center
for
Disease
Control
Prevention
Surveillance,
Epidemiology,
End
Results
database.
mortality
HNC
Ohio
were
identified
sub
classified
based
anatomical
site.
Social
determinants
health
environmental
factors
affecting
raters
compared
(R
=
0.9,
P
<
0.01)
0.8,
increased
significantly
1999
2021
demonstrated
a
relationship
with
0.3,
0.01).
Adult
smoking
0.5,
0.001),
obesity
dentist
associated
rates.
Mean
(mean
10.7,
SD
2.6)
than
8.6,
2.4)
regions
(P
communities.
These
findings
emphasize
importance
addressing
modifiable
risk
through
cessation,
weight
management,
dietary
improvements.
difference
underscores
role
geographic
socioeconomic
shaping
outcomes
Ohio.
Язык: Английский
Survival Outcomes of Surgically Treated Oral Cavity Squamous Cell Carcinoma Patients at Tertiary Care Hospital in Northern Thailand
Journal of Stomatology Oral and Maxillofacial Surgery,
Год журнала:
2024,
Номер
unknown, С. 102166 - 102166
Опубликована: Ноя. 1, 2024
Язык: Английский