Exploring the Role of Cellular Interactions in the Colorectal Cancer Microenvironment DOI Creative Commons
Jiadai Tang, Lixin Chen, Xin Shen

и другие.

Journal of Immunology Research, Год журнала: 2025, Номер 2025(1)

Опубликована: Янв. 1, 2025

Colorectal cancer (CRC) stands as one of the tumors with globally high incidence and mortality rates. In recent years, researchers have extensively explored role tumor immune microenvironment (TME) in CRC, highlighting crucial influence cell populations driving progression shaping therapeutic outcomes. The TME encompasses an array cellular noncellular constituents, spanning cells, myeloid tumor-associated fibroblasts, among others. However, composition within is highly dynamic, evolving throughout different stages progression. These shifts subpopulation proportions lead to a gradual transition response, shifting from early antitumor growth late-stage environment that supports survival. Therefore, it further investigate understand complex interactions various TME. this review, we explore key components varying origins, subpopulations shared elements CRC TME, examining their interconnections critical considerations for developing personalized precise immunotherapy strategies.

Язык: Английский

Exploring the Role of Cellular Interactions in the Colorectal Cancer Microenvironment DOI Creative Commons
Jiadai Tang, Lixin Chen, Xin Shen

и другие.

Journal of Immunology Research, Год журнала: 2025, Номер 2025(1)

Опубликована: Янв. 1, 2025

Colorectal cancer (CRC) stands as one of the tumors with globally high incidence and mortality rates. In recent years, researchers have extensively explored role tumor immune microenvironment (TME) in CRC, highlighting crucial influence cell populations driving progression shaping therapeutic outcomes. The TME encompasses an array cellular noncellular constituents, spanning cells, myeloid tumor-associated fibroblasts, among others. However, composition within is highly dynamic, evolving throughout different stages progression. These shifts subpopulation proportions lead to a gradual transition response, shifting from early antitumor growth late-stage environment that supports survival. Therefore, it further investigate understand complex interactions various TME. this review, we explore key components varying origins, subpopulations shared elements CRC TME, examining their interconnections critical considerations for developing personalized precise immunotherapy strategies.

Язык: Английский

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