Hallmarks of Neuroblastoma—Pathophysiology, Diagnosis, and Therapeutic Interventions DOI Creative Commons
Abhimanyu Thakur, Anne Bert Dijkstra

Опубликована: Май 19, 2025

ABSTRACT Neuroblastoma, the most common extracranial solid tumor in childhood, continues to challenge clinicians and researchers because of its heterogeneous nature complex pathophysiology. Recent breakthroughs molecular profiling revealed intricate genetic alterations driving progression, necessitating an updated perspective on disease’s Rapid advancements diagnostic techniques, including novel imaging modalities assays, warrant a thorough examination guide clinical decision‐making. Furthermore, emergence targeted therapies immunotherapeutic approaches dramatically shifted treatment landscape, creating urgent need for critical evaluation their efficacy integration into existing protocols. This comprehensive review is critically needed synthesize latest understanding hallmarks neuroblastoma, evolving therapeutic approaches. By consolidating current knowledge identifying gaps, this aims provide valuable resource researchers, potentially catalyzing new research directions improving patient outcomes.

Язык: Английский

Hallmarks of Neuroblastoma—Pathophysiology, Diagnosis, and Therapeutic Interventions DOI Creative Commons
Abhimanyu Thakur, Anne Bert Dijkstra

Опубликована: Май 19, 2025

ABSTRACT Neuroblastoma, the most common extracranial solid tumor in childhood, continues to challenge clinicians and researchers because of its heterogeneous nature complex pathophysiology. Recent breakthroughs molecular profiling revealed intricate genetic alterations driving progression, necessitating an updated perspective on disease’s Rapid advancements diagnostic techniques, including novel imaging modalities assays, warrant a thorough examination guide clinical decision‐making. Furthermore, emergence targeted therapies immunotherapeutic approaches dramatically shifted treatment landscape, creating urgent need for critical evaluation their efficacy integration into existing protocols. This comprehensive review is critically needed synthesize latest understanding hallmarks neuroblastoma, evolving therapeutic approaches. By consolidating current knowledge identifying gaps, this aims provide valuable resource researchers, potentially catalyzing new research directions improving patient outcomes.

Язык: Английский

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