Roles of programmed cell death in paramyxovirus infection DOI Creative Commons
Ye Liu, Yilong Wang,

Zhixu He

и другие.

Journal of Zhejiang University (Medical Sciences), Год журнала: 2025, Номер unknown

Опубликована: Май 1, 2025

Paramyxoviruses are significant respiratory pathogens with substantial clinical relevance in pediatric infectious diseases. During infection, they induce multiple forms of programmed cell death (PCD), which play pivotal roles viral replication, dissemination, and host immune responses, thereby profoundly influencing the life cycle disease progression. On one hand, PCD facilitates clearance infected cells, restricts spread, activates defenses, enhancing antiviral immunity. other excessive or dysregulated may lead to tissue damage imbalance, creating a microenvironment conducive replication exacerbating severity. For instance, apoptosis-mediated by both intrinsic extrinsic pathways-contributes infection control but also be hijacked viruses promote dissemination. Pyroptosis, driven inflammasome activation, triggers lytic release pro-inflammatory cytokines. Necroptosis, mediated RIPK1-RIPK3-MLKL signaling axis, pyroptosis amplify innate responses concurrently inflammatory dysregulation. Immunogenic (ICD), characterized damage-associated molecular patterns (DAMPs) neoantigens, antigen-specific holds therapeutic potential for antitumor interventions. Emerging evidence suggests that ferroptosis, through modulation iron metabolism associated transporters, participate clearance. This review comprehensively summarizes apoptosis, pyroptosis, necroptosis, ICD, ferroptosis paramyxovirus aiming deepen understanding pathogenesis provide insights developing novel strategies, particularly populations.

Язык: Английский

Roles of programmed cell death in paramyxovirus infection DOI Creative Commons
Ye Liu, Yilong Wang,

Zhixu He

и другие.

Journal of Zhejiang University (Medical Sciences), Год журнала: 2025, Номер unknown

Опубликована: Май 1, 2025

Paramyxoviruses are significant respiratory pathogens with substantial clinical relevance in pediatric infectious diseases. During infection, they induce multiple forms of programmed cell death (PCD), which play pivotal roles viral replication, dissemination, and host immune responses, thereby profoundly influencing the life cycle disease progression. On one hand, PCD facilitates clearance infected cells, restricts spread, activates defenses, enhancing antiviral immunity. other excessive or dysregulated may lead to tissue damage imbalance, creating a microenvironment conducive replication exacerbating severity. For instance, apoptosis-mediated by both intrinsic extrinsic pathways-contributes infection control but also be hijacked viruses promote dissemination. Pyroptosis, driven inflammasome activation, triggers lytic release pro-inflammatory cytokines. Necroptosis, mediated RIPK1-RIPK3-MLKL signaling axis, pyroptosis amplify innate responses concurrently inflammatory dysregulation. Immunogenic (ICD), characterized damage-associated molecular patterns (DAMPs) neoantigens, antigen-specific holds therapeutic potential for antitumor interventions. Emerging evidence suggests that ferroptosis, through modulation iron metabolism associated transporters, participate clearance. This review comprehensively summarizes apoptosis, pyroptosis, necroptosis, ICD, ferroptosis paramyxovirus aiming deepen understanding pathogenesis provide insights developing novel strategies, particularly populations.

Язык: Английский

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