Clinical Science,
Год журнала:
2020,
Номер
134(12), С. 1403 - 1432
Опубликована: Июнь 1, 2020
Flavonoids
are
polyphenolic
compounds
naturally
occurring
in
fruits
and
vegetables,
addition
to
beverages
such
as
tea
coffee.
emerging
potent
therapeutic
agents
for
cardiovascular
well
metabolic
diseases.
Several
studies
corroborated
an
inverse
relationship
between
flavonoid
consumption
disease
(CVD)
or
adipose
tissue
inflammation
(ATI).
exert
their
anti-atherogenic
effects
by
increasing
nitric
oxide
(NO),
reducing
reactive
oxygen
species
(ROS),
decreasing
pro-inflammatory
cytokines.
In
addition,
flavonoids
alleviate
ATI
triglyceride
cholesterol
levels,
attenuating
inflammatory
mediators.
Furthermore,
inhibit
synthesis
of
fatty
acids
promote
oxidation.
this
review,
we
discuss
the
effect
main
classes
flavonoids,
namely
flavones,
flavonols,
flavanols,
flavanones,
anthocyanins,
isoflavones,
on
atherosclerosis
ATI.
dissect
underlying
molecular
cellular
mechanisms
action
these
flavonoids.
We
conclude
supporting
potential
benefit
management
treatment
CVD;
yet,
call
more
robust
clinical
safety
pharmacokinetic
values.
Drugs and Drug Candidates,
Год журнала:
2025,
Номер
4(1), С. 4 - 4
Опубликована: Фев. 5, 2025
Background/Objectives:
The
interaction
of
bioactive
compounds
derived
from
plants
with
drugs
has
become
a
significant
area
investigation
due
to
its
potential
improve,
reduce,
or
have
no
effect
on
therapeutic
outcomes.
Due
the
dual
these
interactions,
elucidating
underlying
mechanisms
is
essential
for
establishing
strategy.
This
study
emphasizes
findings,
mechanisms,
and
clinical
implications
drug–plant
interactions.
It
calls
more
studies
seek
safe
effective
incorporation
into
practice.
Methods:
To
identify
relevant
studies,
we
performed
systematic
literature
search
based
various
scientific
databases
11
August
2024
30
December
2024.
will
be
keywords
such
as
synergy,
antagonism,
plant
compounds,
drug
interactions
supplemented
secondary
terms
phytochemicals,
herb-drug
pharmacokinetics,
pharmacodynamics.
Results:
Plant
bioactives,
including
polyphenols,
flavonoids,
alkaloids,
terpenoids,
display
valuable
biological
activities
that
can
interact
medications
in
three
principal
ways:
additive
effects,
antagonism.
Synergy
occurs
when
combined
effects
chemicals
pharmaceuticals
outweigh
sum
their
separate
increasing
effectiveness
allowing
dosage
decrease
reduce
adverse
effects.
Additive
occur
impact
equals
total
individual
resulting
better
outcomes
without
risk.
Antagonism
ingredient
reduces
counteracts
medicine,
thereby
jeopardizing
treatment.
In
addition,
specific
may
discernible
effect.
chemical
makeup
chemicals,
medication
patient
characteristics
genetics
metabolism
all
intricacy
Conclusions:
Pharmacokinetics
pharmacodynamics
considerably
modulated
through
components,
which
cause
efficacy
increase
toxicity
agents.
More
are
needed
clarify
action,
prove
relevance,
create
guidelines
co-administration.
integrative
approach
mitigate
those
risks
allow
optimization
by
introducing
pharmacogenomics
personalized
medicine
approaches.
Biomedicines,
Год журнала:
2025,
Номер
13(2), С. 454 - 454
Опубликована: Фев. 12, 2025
Conditions
like
diabetes
mellitus
(DM),
cancer,
infections,
inflammation,
cardiovascular
diseases
(CVDs),
and
gastrointestinal
(GI)
disorders
continue
to
have
a
major
global
impact
on
mortality
morbidity.
Medicinal
plants
been
used
since
ancient
times
in
ethnomedicine
(e.g.,
Ayurveda,
Unani,
Traditional
Chinese
Medicine,
European
Medicine)
for
the
treatment
of
wide
range
disorders.
Plants
are
rich
source
diverse
phytoconstituents
with
antidiabetic,
anticancer,
antimicrobial,
antihypertensive,
antioxidant,
antihyperlipidemic,
cardioprotective,
immunomodulatory,
and/or
anti-inflammatory
activities.
This
review
focuses
35
most
commonly
reported
these
disorders,
particular
emphasis
their
traditional
uses,
phytoconstituent
contents,
pharmacological
properties,
modes
action.
Active
phytomolecules
therapeutic
potential
include
cucurbitane
triterpenoids,
diosgenin,
limonoids
(azadiradione
gedunin),
which
exhibit
antidiabetic
triterpenoids
specifically
activating
Glucose
Transporter
Type
4
(GLUT4)
translocation.
Capsaicin
curcumin
demonstrate
anticancer
activity
by
deactivating
NF-κB
arresting
cell
cycle
G2
phase.
Antimicrobial
activities
observed
piperine,
reserpine,
berberine,
dictamnine,
chelerythrine,
allitridin,
latter
two
triggering
bacterial
lysis.
Quercetin,
catechin,
genistein
suppressing
CD8+
cytotoxic
T
function.
Ginsenoside
Rg1
ginsenoside
Rg3
treating
diseases,
PPARα
promoter,
PI3K/Akt
pathway.
In
contrast,
ternatin,
tannins,
quercitrin
regulating
arachidonic
acid
metabolism
cyclooxygenase
(COX)
lipoxygenase
activity.
Further
studies
warranted
fully
investigate
clinical
benefits
phytoconstituents,
as
well
elucidate
underlying
molecular
mechanisms
Journal of Ethnopharmacology,
Год журнала:
2020,
Номер
266, С. 113436 - 113436
Опубликована: Окт. 1, 2020
Dingxin
Recipe
(DXR)
is
a
traditional
Chinese
medicine
formula
that
has
been
reported
to
be
effective
and
safe
treatment
for
cardiovascular
diseases,
such
as
arrhythmias,
coronary
heart
disease.
IV
(DXR
IV)
was
further
improved
from
the
DXR
according
use.
However,
mechanism
of
in
atherosclerosis
unclear.
This
study
aimed
illustrate
whether
improve
through
modulating
lipid
metabolism
gut
microbiota
mice.
40
male
ApoE-/-
mice
were
fed
on
HFD
12
weeks
then
treated
with
(1.8,
0.9,
or
0.45
g/kg/d)
another
weeks.
The
decroation
contains
four
medicines:
dried
rhizome
Coptis
chinensis
Franch.
(15.09%),
root
Salvia
miltiorrhiza
Bunge
(28.30%),
seed
Ziziphus
jujuba
Mill.
(37.74%)
fruiting
body
Ganoderma
lucidum
(Leyss.ex
Fr.)
Karst.
(18.87%).
8
c57BL/6
normal
diet
served
control
group.
atherosclerotic
plaque
quantified
by
oil-red
O
staining
masson
trichrome
staining.
Mice
feces
collected.
micobiota
detected
16S
rRNA
gene
sequencing
fecal
metabolites
analyzed
1H
NMR
spectroscopy.
effect
blood
lipids
(TG,
TC,
LDL-C,
HDL-C)
investigated.
related
genes
determined
RT-qPCR
western
blotting
respectively.
exerted
anti-atherosclerosis
inhibiting
excessive
cholesterol
deposition
aorta
regulating
level
TG,
LDL-C
HDL-C.
composition
changed.
Interestingly,
relative
abundance
Muribaculaceae
Ruminococcaceae
increased
after
administration,
whereas
Erysipelotrichaceae
decreased,
which
have
beneficial
metabolism.
Nine
potential
metabolic
biomarkers,
including
acetate,
butyrate,
propionate,
alanine,
succinate,
valerate,
xylose,
choline,
glutamate,
identified,
fatty
acid
Further,
pathway
blotting.
Compared
model
group,
LXR-α
SREBP1
decreased
significantly
group
while
LXR-β,
SREBP2
showed
no
statistical
significance.
It
indicated
modulated
LXR-α/SREBP1
but
not
LXRβ
SREBP2.
exhibits
effect,
closely
microbiota.
may
provide
novel
insights
into
basis
promising
clinical
usage.
Clinical Science,
Год журнала:
2020,
Номер
134(12), С. 1403 - 1432
Опубликована: Июнь 1, 2020
Flavonoids
are
polyphenolic
compounds
naturally
occurring
in
fruits
and
vegetables,
addition
to
beverages
such
as
tea
coffee.
emerging
potent
therapeutic
agents
for
cardiovascular
well
metabolic
diseases.
Several
studies
corroborated
an
inverse
relationship
between
flavonoid
consumption
disease
(CVD)
or
adipose
tissue
inflammation
(ATI).
exert
their
anti-atherogenic
effects
by
increasing
nitric
oxide
(NO),
reducing
reactive
oxygen
species
(ROS),
decreasing
pro-inflammatory
cytokines.
In
addition,
flavonoids
alleviate
ATI
triglyceride
cholesterol
levels,
attenuating
inflammatory
mediators.
Furthermore,
inhibit
synthesis
of
fatty
acids
promote
oxidation.
this
review,
we
discuss
the
effect
main
classes
flavonoids,
namely
flavones,
flavonols,
flavanols,
flavanones,
anthocyanins,
isoflavones,
on
atherosclerosis
ATI.
dissect
underlying
molecular
cellular
mechanisms
action
these
flavonoids.
We
conclude
supporting
potential
benefit
management
treatment
CVD;
yet,
call
more
robust
clinical
safety
pharmacokinetic
values.
