Journal of Drug Delivery and Therapeutics,
Год журнала:
2022,
Номер
12(1-S), С. 123 - 131
Опубликована: Фев. 22, 2022
Wide-reaching
interest
in
use
of
plant
derived
secondary
metabolites
(PDSMs)
has
been
growing
world
over.
This
implies
that
the
beneficial
effects
based
natural
products
(PBNPs)
being
rediscovered
and
harnessed
for
development
novel
drugs;
drug-leads
structural
background
drug
design.
Survey
literature
on
indigenous
traditional
medicinal
knowledge
bestows
ethnopharmacological
potentials
PBNPs
inspired
design
through
research
discovery;
provide
baseline
leads
against
various
pharmacological
targets.
Studies
indicate
Cymbopogon
martini
Essential
Oil
(CMEO)
exhibits
a
wide
range
biological
activities
(anticancer,
antidiabetic,
antibacterial,
antifungal,
antioxidant,
hepatoprotective
insecticide)
attributed
to
presence
bio-active
(BASM).
However,
wide-spread
application
CMEO
is
limited
because
typical
odor,
color
taste.
In
present
study,
In-silico
Absorption,
Distribution,
Metabolism,
Elimination,
Toxicity
(ADMET)
studies
β-caryophyllene
(BCP)
from
martinii
envisaged.
enhances
wound
healing
multiple
routes
therefore,
Non
AMES
toxic,
Non-carcinogens,
biodegradable
nature
prospects
this
compound
as
considered
an
apt
lead
drugs
treatment
cuts
wounds
besides
other
diseases
viz.,
diabetics,
cancer,
metabolic
inflammation
long
term
complications
associated
with
these
diseases.
particular,
BCP
inhibits
cytochrome
P450
isoforms
(CYP3A4)
metabolize
xenobiotics
results
adverse
effects.
Pharmacokinetic
properties
predicted
score
values
have
highlighted
both
toxicological
aspects
need
be
further
investigated
before
put
clinical
trials.
Keywords:
ADMET;
β-caryophyllene;
martinii;
Cardiotoxicity;
Cytotoxicity;
Drugability;
Pharmacokinetics;
Bioactivity;
Oil;
Archiv der Pharmazie,
Год журнала:
2024,
Номер
358(1)
Опубликована: Ноя. 14, 2024
Abstract
This
study
deals
with
the
comprehensive
phytochemical
composition
and
antiviral
activity
against
SARS‐CoV‐2
of
acidic
(non‐decarboxylated)
neutral
(decarboxylated)
ethanolic
extracts
from
seven
high‐cannabidiol
(CBD)
two
high‐Δ
9
‐tetrahydrocannabinol
(Δ
‐THC)
Cannabis
sativa
L.
genotypes.
Their
secondary
metabolite
profiles,
phytocannabinoid,
terpenoid,
phenolic,
were
determined
by
LC‐UV,
GC‐MS,
LC‐MS/MS
analyses,
respectively.
All
three
cannabinoid,
varied
significantly
among
cannabinoid
different
The
dose–response
analyses
their
showed
that
only
single
predominant
phytocannabinoids
(CBD
or
THC)
exhibited
(all
IC
50
<
10.0
μM).
correlation
matrix
between
phytoconstituent
levels
revealed
phenolic
acids,
salicylic
acid
its
glucoside,
chlorogenic
acid,
ferulic
flavonoids,
abietin,
luteolin,
in
high‐CBD
genotypes
are
implicated
genotype‐distinct
antagonistic
effects
on
phytocannabinoid.
On
other
hand,
these
also
suggested
flavonoid
orientin
can
enrich
extract's
pharmacological
profiles.
Thus,
further
preclinical
studies
extract
formulations
adjusted
non‐phytocannabinoid
compositions
warranted
to
develop
supplementary
treatments.
Journal of Drug Delivery and Therapeutics,
Год журнала:
2022,
Номер
12(1-S), С. 123 - 131
Опубликована: Фев. 22, 2022
Wide-reaching
interest
in
use
of
plant
derived
secondary
metabolites
(PDSMs)
has
been
growing
world
over.
This
implies
that
the
beneficial
effects
based
natural
products
(PBNPs)
being
rediscovered
and
harnessed
for
development
novel
drugs;
drug-leads
structural
background
drug
design.
Survey
literature
on
indigenous
traditional
medicinal
knowledge
bestows
ethnopharmacological
potentials
PBNPs
inspired
design
through
research
discovery;
provide
baseline
leads
against
various
pharmacological
targets.
Studies
indicate
Cymbopogon
martini
Essential
Oil
(CMEO)
exhibits
a
wide
range
biological
activities
(anticancer,
antidiabetic,
antibacterial,
antifungal,
antioxidant,
hepatoprotective
insecticide)
attributed
to
presence
bio-active
(BASM).
However,
wide-spread
application
CMEO
is
limited
because
typical
odor,
color
taste.
In
present
study,
In-silico
Absorption,
Distribution,
Metabolism,
Elimination,
Toxicity
(ADMET)
studies
β-caryophyllene
(BCP)
from
martinii
envisaged.
enhances
wound
healing
multiple
routes
therefore,
Non
AMES
toxic,
Non-carcinogens,
biodegradable
nature
prospects
this
compound
as
considered
an
apt
lead
drugs
treatment
cuts
wounds
besides
other
diseases
viz.,
diabetics,
cancer,
metabolic
inflammation
long
term
complications
associated
with
these
diseases.
particular,
BCP
inhibits
cytochrome
P450
isoforms
(CYP3A4)
metabolize
xenobiotics
results
adverse
effects.
Pharmacokinetic
properties
predicted
score
values
have
highlighted
both
toxicological
aspects
need
be
further
investigated
before
put
clinical
trials.
Keywords:
ADMET;
β-caryophyllene;
martinii;
Cardiotoxicity;
Cytotoxicity;
Drugability;
Pharmacokinetics;
Bioactivity;
Oil;
