Research Square (Research Square),
Год журнала:
2023,
Номер
unknown
Опубликована: Янв. 4, 2023
Abstract
Colorectal
cancer
(CRC)
is
one
of
the
most
common
malignant
tumors
with
a
poor
prognosis.
Long
noncoding
RNAs
(lncRNAs)
were
reported
to
play
vital
role
in
regulating
progression
cancers
and
had
been
become
focus
intense
research
biology.
Meanwhile,
LINC01134
functions
as
an
oncogene
many
cancers,
but
possible
roles
mechanisms
occurrence
development
CRC
are
still
unclear.
This
study
aimed
explore
biological
mechanism
CRC.
First,
we
found
was
highly
expressed
tissues
associated
worse
clinical
stages
prognosis,
which
line
that
cell
lines.
Functional
experiments
indicated
silencing
attenuated
cells
proliferation
induced
apoptosis
both
vitro
vivo.
Mechanistically,
weighted
gene
co-expression
analysis
identified
positively
related
SLC1A5,
also
upregulated
prognosis
Going
further,
RNA–RNA
interaction
mRNA
stability
could
directly
bind
SLC1A5
enhance
stability.
Notably,
partly
reverse
promotion
effect
overexpression
on
inhibitory
cells.
Our
findings
showed
acted
via
binding
enhancing
stability,
suggested
might
act
promising
therapeutic
target
for
Biomedicine & Pharmacotherapy,
Год журнала:
2022,
Номер
154, С. 113609 - 113609
Опубликована: Авг. 27, 2022
Epigenetic
factors
are
critical
regulators
of
biological
and
pathological
mechanisms
they
could
interact
with
different
molecular
pathways.
Targeting
epigenetic
has
been
an
idea
approach
in
disease
therapy,
especially
cancer.
Accumulating
evidence
highlighted
function
long
non-coding
RNAs
(lncRNAs)
as
cancer
initiation
development
focused
on
their
association
downstream
targets.
microRNAs
(miRNAs)
the
most
well-known
targets
lncRNAs
present
review
focuses
lncRNA-miRNA
axis
malignancy
therapy
resistance
tumors.
LncRNA-miRNA
regulates
cell
death
such
apoptosis
autophagy
cancers.
This
affects
tumor
metastasis
via
regulating
EMT
MMPs.
Besides,
determines
sensitivity
cells
to
chemotherapy,
radiotherapy
immunotherapy.
Based
studies,
can
be
affected
by
drugs
genetic
tools
this
may
affect
expression
level
miRNAs
targets,
leading
suppression/progression.
LncRNAs
have
both
tumor-promoting
tumor-suppressor
functions
unique
complicated
implication
therapy.
also
other
signaling
networks
PI3K/Akt,
STAT3,
Wnt/β-catenin
EZH2
among
others.
Notably,
lncRNA/miRNA
considered
a
signature
for
diagnosis
prognosis
Biomedicine & Pharmacotherapy,
Год журнала:
2023,
Номер
165, С. 115187 - 115187
Опубликована: Июль 25, 2023
Brain
tumors,
which
are
highly
malignant,
pose
a
significant
threat
to
health
and
often
result
in
substantial
rates
of
mortality
morbidity
worldwide.
The
brain
cancer
therapy
has
been
challenging
due
obstacles
such
as
the
BBB,
hinders
effective
delivery
therapeutic
agents.
Additionally,
emergence
drug
resistance
further
complicates
management
tumors.
TMZ
is
utilized
removal,
but
drawback.
ncRNAs
implicated
various
diseases,
their
involvement
particularly
noteworthy.
focus
current
manuscript
explore
controlling
resistance,
specifically
context
chemotherapy
TMZ.
review
emphasizes
function
ncRNAs,
miRNAs,
modulating
growth
invasion
significantly
influences
response
treatment.
Through
interactions
with
molecular
pathways,
miRNAs
modulators
response.
Similarly,
lncRNAs
also
associate
pathways
affecting
efficacy
chemotherapy.
Given
functional
properties,
can
either
induce
or
suppress
Furthermore,
circRNAs,
controllers,
regulate
by
acting
sponges,
thereby
impacting
explores
correlation
between
chemotherapy,
shedding
light
on
underlying
involved
this
process.
Journal of Gastrointestinal Oncology,
Год журнала:
2024,
Номер
15(1), С. 203 - 219
Опубликована: Фев. 1, 2024
Background:
Mucinous
colonic
adenocarcinoma
remains
a
challenging
disease
due
to
its
high
propensity
for
metastasis
and
recurrence.
N7-methylguanosine
(m7G)
long
non-coding
RNA
(lncRNA)
are
closely
associated
with
the
occurrence
progression
of
tumors.
However,
research
on
m7G-related
lncRNA
in
mucinous
is
lacking.
Therefore,
we
sought
explore
prognostic
impact
lncRNAs
(MC)
patients.
Methods:
In
this
study,
Pearson
analysis
was
used
identify
from
transcriptome
data
The
Cancer
Genome
Atlas
(TCGA).
Univariate
Cox
regression
least
absolute
shrinkage
selection
operator
(LASSO)
were
further
screen
incorporate
them
into
signature.
Based
risk
model,
patients
divided
low-
high-risk
groups
randomly
assigned
training
set
test
sets
6:4
ratio.
Kaplan-Meier,
receiver
operating
characteristic
(ROC)
curve,
multivariate
regression,
nomogram
analyses
confirm
accuracy
CIBERSORT
algorithm
calculate
degree
immune
cell
infiltration
(ICI).
Finally,
correlation
signature
tumor
mutational
burden
(TMB)
immunophenotype
score
(IPS)
evaluated.
Results:
A
total
432
identified
by
analysis.
LASSO
survival
performed
select
six
(P<0.05):
AC254629.1,
LINC01133,
LINC01134,
MHENCR,
SMIM2-AS1,
XACT.
heat
maps,
Kaplan-Meier
curves,
ROC
curves
constructed,
results
showed
that
there
significant
differences
expression
levels
status
between
two
groups.
area
under
curve
(AUC)
values
3-,
5-,
10-year
0.944,
0.957,
1.000,
respectively.
And
0.964,
Subsequently,
univariate
clinical
characteristics
performed.
[hazard
ratio
(HR):
6.458,
95%
confidence
interval
(CI):
2.708–15.403,
P<0.001;
HR:
7.280,
CI:
2.500–21.203,
P<0.001],
Using
as
an
independent
factor,
AUC
it
over
3,
5,
10
years
0.911,
0.955,
0.961,
Calibration
plots
show
model
calibration
line
very
close
ideal
line,
indicating
good
calibration.
level
ICI
significantly
different
Survival
that,
regardless
TMB
risk,
MC
consistently
had
poor
overall
(OS).
Conclusions:
has
potential
value
prognosis
adenocarcinoma.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Авг. 26, 2024
The
DNA
damage
repair
(DDR)
pathway
is
a
complex
signaling
cascade
that
can
sense
and
trigger
cellular
responses
to
maintain
genome
stability
integrity.
A
typical
hallmark
of
cancer
genomic
instability
or
nonintegrity,
which
closely
related
the
accumulation
within
cells.
treatment
principles
radiotherapy
chemotherapy
for
are
based
on
their
cytotoxic
effects
damage,
accompanied
by
severe
unnecessary
side
normal
tissues,
including
dysregulation
DDR
induced
therapeutic
tolerance.
As
driving
factor
oncogenes
tumor
suppressor
genes,
noncoding
RNA
(ncRNA)
have
been
shown
play
an
important
role
in
cell
resistance
chemotherapy.
Recently,
it
has
found
ncRNA
regulate
tolerance
altering
cells,
indicating
potential
regulatory
factors
targeting
reverse
This
review
provides
overview
basic
information
functions
ncRNAs
sensitivity
tumors
radiation
therapy.
We
focused
impact
(mainly
microRNA
[miRNA],
long
[lncRNA],
circular
[circRNA])
regulating
underlying
molecular
mechanisms
effects.
These
findings
provide
theoretical
basis
new
insights
tumor-targeted
therapy
development
novel
drugs
ncRNAs.
