1,2,3-Triazole-based betulinic acid derivatives as α-glucosidase inhibitors: Synthesis and in vitro and in vivo biological evaluation

Journal of Molecular Structure, Год журнала: 2024, Номер 1310, С. 138294 - 138294

Опубликована: Апрель 9, 2024

Язык: Английский

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The Effect of HBV Therapy on Glycemic Control in HBV‐Infected Patients With Diabetes: A 90‐day Multicenter Study

Journal of Medical Virology, Год журнала: 2025, Номер 97(2)

Опубликована: Янв. 27, 2025

Patients with diabetes are at increased risk of HBV infection; however, the effects infection and anti-HBV therapy on management type 1 (T1D), 2 (T2D), latent autoimmune in adults (LADA) remain unclear. From 2016 to 2023, we recruited a multicenter cohort 355 HBV-infected inpatients, including 136 T1D, 140 T2D, 79 LADA. The control group included 525 HBV-uninfected comparing 171 204 T2D 150 We employed propensity-score matching between cases controls minimize confounding effects. Hemoglobin A1c (HbA1c) was monitored baseline months 1, 2, 3. At baseline, median HbA1c significantly higher patients compared their controls: T1D (10.4% vs. 7.5%, p < 0.01), (9.6% 8.6%, = LADA (9.4% 8.4%, 0.03). Baseline levels were lower HBV-treated those HBV-untreated patients, regardless whether they antidiabetic (p 0.05). A 90-day follow-up consistently indicated as well 3 among or Both univariate multivariate analyses identified (OR 0.44, 0.001) treatment(OR 0.51, 0.031) protective factors for glycemic diabetes. Poor is found diabetes, but intervention treatment contributes improved

Язык: Английский

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Change in albuminuria as a surrogate endpoint for cardiovascular and renal outcomes in patients with diabetes

Diabetes Obesity and Metabolism, Год журнала: 2023, Номер 25(6), С. 1434 - 1443

Опубликована: Фев. 21, 2023

Abstract For the purpose of predicting clinical outcomes in patients with diabetes and chronic kidney disease, change albuminuria is a good candidate to be surrogate marker for future cardiovascular events progression disease. Spot urine albumin/creatinine ratio convenient recognized as viable alternative 24‐h albumin, some limitations. Although there sufficient evidence validate its use trials endpoint renal outcomes, this not yet case outcomes. While primary or secondary trial‐specific, should encouraged, nonetheless.

Язык: Английский

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Optimal Medical Management of Atherosclerotic Intracranial Stenosis

Stroke, Год журнала: 2024, Номер 55(2), С. 335 - 343

Опубликована: Янв. 22, 2024

Reducing the high risk of recurrent stroke in patients with symptomatic intracranial atherosclerotic stenosis (sICAS) has proven to be challenging, but aggressive medical management, intensive factor control and antithrombotic therapy, been shown beneficial. High-intensity statins are recommended for stroke, including sICAS. Ezetimibe PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitors beneficial those who fail reach low-density lipoprotein targets or statin intolerance. The treatment target sICAS is <70 mg/dL. In neurologically stable patients, blood pressure should treated goal <140/90 mm Hg use thiazide diuretics, angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers preferentially. For diabetes, treat hemoglobin A1C ≤7% most through combination diet, insulin, hypoglycemic drugs. Some degree physical activity (eg, walking, stationary biking arms legs, etc) encouraged all not severely disabled. A minimum 10 minutes moderate-intensity aerobic 4 times a week capable exercise. severe (70%-99% stenosis), dual antiplatelet therapy up 90 days followed by single agent recommended.

Язык: Английский

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Green synthesis of silver nanoparticles from the essential oil of Curcuma amada and their antihyperglycemic effect in STZ induced diabetic rats

Inorganic Chemistry Communications, Год журнала: 2024, Номер 168, С. 112873 - 112873

Опубликована: Июль 20, 2024

Язык: Английский

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