Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 549 - 570
Опубликована: Янв. 1, 2024
Язык: Английский
Journal of Biochemical and Molecular Toxicology, Год журнала: 2024, Номер 38(11)
Опубликована: Окт. 18, 2024
Traumatic brain injury (TBI) causes deficits in neurological function, induces pathological changes, and increases oxidative stress. The current investigation aimed to determine Daidzein's neuroprotective potential experimental TBI. Initially, the HT-22 cell line exposed H
Язык: Английский
Процитировано
1
Advances in Human Biology, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 15, 2024
Abstract Neuropharmacology explores how drugs influence the nervous system and their potential in treating neurological psychiatric disorders. This review provides a comprehensive overview of mechanisms through which various impact neural processes therapeutic applications. It covers major drug classes, including antipsychotics, antidepressants, anxiolytics neuroprotective agents, highlighting modes action, efficacy limitations. Advances development, such as targeted therapies novel compounds, are discussed about to improve treatment outcomes for disorders schizophrenia, depression, anxiety neurodegenerative diseases. Understanding these is crucial developing more effective safer treatments.
Язык: Английский
Процитировано
1
Frontiers in Pharmacology, Год журнала: 2023, Номер 14
Опубликована: Ноя. 15, 2023
Simira cordifolia (Hook.f.) Steyerm (Rubiaceae) is a vascular plant used in Northern Colombia as source of pigments and wood. However, there lack information regarding its pharmacology toxicity. This research aimed to study the hydroalcoholic extract protector against metal-induced toxicity Caenorhabditis elegans . Preliminary phytochemical screening S. (HAE-Sc) was conducted using HPLC-ESI-QTOF. Wild-type N2 C. larvae were exposed different concentrations HAE-Sc evaluating lethality (50–5000 μg/mL), growth, lifespan, resistance heat stress, protective effect Mercury (Hg)-, Lead (Pb)- Cadmium (Cd)-induced (50–1000 μg/mL). The main metabolites present iridoids, β-carboline-alkaloids polyphenols. Bioassays demonstrated that exhibited low toxicity, with significant (4.2% 9.4%) occurring at 2500–5000 μg/mL. Growth inhibition reached up 23.3%, while reproduction declined 13% 17% 500 1000 μg/mL, respectively. enhanced survival rate nematode under thermal stress by 79.8%, extended mean lifespan worms over 33% compared control. average prolonged 15.3% 18.5% 50 100 μg/mL HAE-Sc, (1000 μg/mL) able reduce death presence heavy metals 65.9, 96.8% 87% for Pb, Hg, Cd, In summary, shows potential effects caused heat.
Язык: Английский
Процитировано
1
Annual Research & Review in Biology, Год журнала: 2023, Номер unknown, С. 20 - 33
Опубликована: Дек. 30, 2023
Turmeric has served as a potential chemotherapeutic and chemo-preventive drug in Asia for about four to five thousand years of human civilization. It occupies significant place religious rituals, kitchens food additives, many ethno-phyto-pharmaceutical safe drugs worldwide. India is the top producer (about 80%), leading exporter turmeric, rich containing curcumin turmerone oil world. The demand turmeric its marketing strategy reached peak naturopathic choice during SARS-02 pandemic from 2020 onwards. Indian yellow saffron grows an organic spice augment economic, societal, environmental conditions tribal hilly areas adding value chain. existing study envisages evaluation levels all chemical constituents including heavy/radioactive metals present so that widely used may have some refinement enhance safety standards. MITUTOYO microscope X-ray fluorescence Spectrometer (XRF) were both black varieties specimens various places like Kandhamal, Koraput, Khordha districts examine compare contents. Turmeric, variety rhizome Zingiberaceae (ginger) family, mostly grown by using methodology terrains India. Iron few rare earth are small proportions but zinc which immune developer body almost absent turmeric. volatile oil, colouring materials, culinary flavoured spices, or common cosmetics extracted They wide applications Ayurveda cardio-protective, Anti-septic, blood level depressant, anti-cancer, antioxidant, antifertility, antidepressant, anti-allergic, anti-inflammatory, neuro/ nephron-protective, immune-modulatory, anti-microbial, etc. Despite well-proven naturopathy Ayurveda, not accepted ingredient pharmacy, modern allopathic structure, needs attention.
Язык: Английский
Процитировано
1
Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 549 - 570
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
0