medRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 6, 2024
Excessive
Manganese
(Mn)
exposure
is
neurotoxic
and
can
cause
Mn-Induced
Parkinsonism
(MnIP),
marked
by
cognitive
motor
dysfunction.
Although
metabolomic
lipidomic
research
in
(PD)
patients
exists,
it
remains
limited.
This
study
hypothesizes
distinct
profiles
based
on
status,
disease
diagnosis,
their
interaction.
Toxicological Sciences,
Год журнала:
2024,
Номер
199(1), С. 1 - 11
Опубликована: Фев. 20, 2024
Abstract
Intestinal
failure-associated
liver
disease
(IFALD)
is
a
relatively
common
complication
in
individuals
receiving
parenteral
nutrition
(PN).
IFALD
can
be
manifested
as
different
types
of
injury,
including
steatosis,
cholestasis,
and
fibrosis,
could
result
failure
some
cases.
The
onset
progression
are
highly
dependent
on
various
patient
PN-related
risk
factors.
Despite
still
being
under
investigation,
several
mechanisms
have
been
proposed.
Liver
injury
originate
due
to
caloric
overload,
nutrient
deficiency,
toxicity,
well
phytosterol
content,
omega-6
omega-3
fatty
acids
ratio
contained
lipid
emulsions.
Additional
include
immature
or
defective
bile
acid
metabolism,
acute
heart
failure,
infections,
sepsis
exerting
negative
effects
via
Toll-like
receptor
4
nuclear
factor
κB
inflammatory
signaling.
Furthermore,
lack
enteral
feeding,
gut
dysbiosis,
altered
enterohepatic
circulation
that
affect
the
farnesoid
x
receptor-fibroblast
growth
19
axis
also
contribute
IFALD.
Various
best
practices
adopted
minimize
developing
IFALD,
such
prevention
management
central
line
infections
sepsis,
preservation
intestine’s
length,
switch
oral
cyclic
PN,
avoidance
overfeeding
soybean
oil-based
formulations,
avoiding
hepatotoxic
substances.
present
review
thus
provides
comprehensive
overview
all
relevant
aspects
inherent
Further
research
focused
clinical
observations,
translational
models,
advanced
toxicological
knowledge
frameworks
needed
gain
more
insight
into
molecular
pathogenesis
hepatotoxicity,
reduce
incidence,
encourage
safe
use
PN.
Following
a
request
from
the
European
Commission
(EC),
EFSA
Panel
on
Nutrition,
Novel
Foods
and
Food
Allergens
(NDA)
was
asked
to
deliver
scientific
opinion
tolerable
upper
intake
level
(UL)
for
manganese.
Systematic
reviews
of
literature
human
animal
data
were
conducted
assess
evidence
regarding
excess
manganese
(including
authorised
salts)
priority
adverse
health
effect,
i.e.
manganese-induced
neurotoxicity.
Available
studies
support
neurotoxicity
as
critical
however,
are
not
sufficient
suitable
characterise
dose–response
relationship
identify
reference
point
In
absence
adequate
establish
an
UL,
estimated
background
dietary
intakes
(i.e.
natural
sources
only)
observed
among
high
consumers
(95th
percentile)
used
provide
indication
highest
where
there
is
reasonable
confidence
effects.
A
safe
8
mg/day
established
adults
≥
18
years
pregnant
lactating
women)
ranged
between
2
7
other
population
groups.
The
application
more
limited
than
UL
because
at
which
risk
effects
starts
increase
defined.
Epigenomics,
Год журнала:
2024,
Номер
16(1), С. 5 - 21
Опубликована: Янв. 1, 2024
Aim:
To
explore
the
specific
histone
acetylation
sites
and
oxidative
stress-related
genes
that
are
associated
with
pathogenesis
of
manganese
toxicity.
Methods:
We
employed
liquid
chromatography-tandem
mass
spectrometry
bioinformatics
analysis
to
identify
acetylated
proteins
in
striatum
subchronic
manganese-intoxicated
rats.
Results:
identified
a
total
12
differentially
modified
sites:
H3K9ac,
H3K14ac,
H3K18ac,
H3K56ac
H3K79ac
were
upregulated
H3K27ac,
H3K36ac,
H4K91ac,
H4K79ac,
H4K31ac,
H2BK16ac
H2BK20ac
downregulated.
Additionally,
we
found
CAT,
SOD1
SOD2
might
be
epigenetically
regulated
involved
manganism.
Conclusion:
This
study
toxicity,
these
findings
useful
search
for
potential
epigenetic
targets
Heliyon,
Год журнала:
2024,
Номер
10(7), С. e28043 - e28043
Опубликована: Март 28, 2024
Rice,
a
primary
food
source
in
many
countries
of
the
world
accumulate
potentially
harmful
elements
which
pose
significant
health
hazard
to
consumers.
The
current
study
aimed
evaluate
toxic
and
mineral
both
paddy
soils
rice
grains
associated
with
allied
risks
Malakand,
Pakistan.
Rice
plants
intact
root
soil
were
randomly
collected
from
fields
analyzed
for
(PTEs)
through
inductively
coupled
plasma
optical
emission
spectrometry
(ICP‒OES).
Through
deterministic
probabilistic
risk
assessment
models,
daily
intake
PTEs
consumption
estimated
children
adults.
results
pH
(<8.5)
electrical
conductivity
(EC
>
400
μs/cm),
indicated
slightly
saline
nature.
mean
phosphorus
concentration
291.50
(mg/kg)
samples
exceeded
FAO/WHO
permissible
limits.
normalized
variation
matrix
respect
Ni
(0.05),
Ca
EC
(0.08),
Mg
(0.09),
influence
on
mobility.
In
grains,
concentrations
(463.81),
Al
(70.40),
As
(1.23),
Cr
(12.53),
Cu
(36.07),
Fe
(144.32),
Mn
(13.89),
(1.60)
safety
transfer
factor
>1
K,
Cu,
P
Zn
bioavailability
these
grains.
Monte
Carlo
simulations
index
Cr,
Zn,
As,
certainties
89.93%
90.17%,
noncarcinogenic
adults
consumption.
total
carcinogenic
(TCR)
USEPA
acceptable
limits
1.0E-06
1.0E-04,
respectively.
sensitivity
analysis
showed
that
ingestion
rate
was
key
factor.
Arsenic
(As)
primarily
influenced
cancer
children,
while
chromium
(Cr)
significantly
impacted
Deterministic
values
due
inherent
uncertainties
analysis.
poses
risks,
mainly
exposure
investigated
area.
CNS Neuroscience & Therapeutics,
Год журнала:
2024,
Номер
30(10)
Опубликована: Окт. 1, 2024
Manganism,
a
central
nervous
system
dysfunction
correlated
with
neurological
deficits
such
as
Parkinsonism,
is
caused
by
the
substantial
collection
of
manganese
chloride
(MnCl
Ecotoxicology and Environmental Safety,
Год журнала:
2025,
Номер
291, С. 117860 - 117860
Опубликована: Фев. 1, 2025
Prenatal
metals
exposure
and
its
effects
on
infant
neurodevelopment
have
garnered
significant
attention.
However,
most
studies
focus
individual
metals,
neglecting
combined
effects.
We
aimed
to
assess
the
of
both
single
prenatal
one-year-old
infants'
neurodevelopment.
This
study
included
189
mother-infant
pairs
from
Complex
Lipids
in
Mothers
Babies
(CLIMB)
cohort.
The
concentrations
21
metallic
elements
2
metalloids
umbilical
cord
blood
(UCB)
serum
were
measured
using
inductively
coupled
plasma
mass
spectrometry
(ICP-MS).
Neurodevelopment
was
Chinese
version
Bayley
Scales
Infant
Development
(BSID)
for
Psychomotor
Index
(PDI)
Mental
(MDI).
Multiple
statistical
methods,
including
linear
models,
restricted
cubic
splines
(RCS),
weighted
quantile
sum
(WQS)
regression,
Bayesian
kernel
machine
regression
(BKMR).
After
adjusting
potential
confounders,
arsenic
(As)
strontium
(Sr)
levels
associated
with
lower
PDI
scores
(As:
β
=
-2.324;
95
%
CI:
-4.61,
-0.04;
Sr:
-2.426;
-4.67,
-0.18)
by
while
Sr
MDI
(β
-2.841;
-5.44,
-0.25).
RCS
models
revealed
nonlinear
dose-response
relationships
between
manganese
(Mn)
calcium
(Ca)
PDI,
Mn,
As,
zirconium
(Zr)
MDI.
Interactions
certain
also
identified.
Metals
mixture
had
an
overall
negative
effect
scores,
Mn
being
primary
contributor.
selected
or
metal
mixtures
is
poorer
infants.