Parenteral nutrition-associated liver injury: clinical relevance and mechanistic insights

Toxicological Sciences, Год журнала: 2024, Номер 199(1), С. 1 - 11

Опубликована: Фев. 20, 2024

Abstract Intestinal failure-associated liver disease (IFALD) is a relatively common complication in individuals receiving parenteral nutrition (PN). IFALD can be manifested as different types of injury, including steatosis, cholestasis, and fibrosis, could result failure some cases. The onset progression are highly dependent on various patient PN-related risk factors. Despite still being under investigation, several mechanisms have been proposed. Liver injury originate due to caloric overload, nutrient deficiency, toxicity, well phytosterol content, omega-6 omega-3 fatty acids ratio contained lipid emulsions. Additional include immature or defective bile acid metabolism, acute heart failure, infections, sepsis exerting negative effects via Toll-like receptor 4 nuclear factor κB inflammatory signaling. Furthermore, lack enteral feeding, gut dysbiosis, altered enterohepatic circulation that affect the farnesoid x receptor-fibroblast growth 19 axis also contribute IFALD. Various best practices adopted minimize developing IFALD, such prevention management central line infections sepsis, preservation intestine’s length, switch oral cyclic PN, avoidance overfeeding soybean oil-based formulations, avoiding hepatotoxic substances. present review thus provides comprehensive overview all relevant aspects inherent Further research focused clinical observations, translational models, advanced toxicological knowledge frameworks needed gain more insight into molecular pathogenesis hepatotoxicity, reduce incidence, encourage safe use PN.

Язык: Английский

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Hybrid morphologies of paramagnetic manganese-based nanoparticles as theranostics

Chemical Engineering Journal, Год журнала: 2023, Номер 466, С. 142970 - 142970

Опубликована: Апрель 18, 2023

Язык: Английский

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Scientific opinion on the tolerable upper intake level for manganese

EFSA Journal, Год журнала: 2023, Номер 21(12)

Опубликована: Дек. 1, 2023

Following a request from the European Commission (EC), EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver scientific opinion tolerable upper intake level (UL) for manganese. Systematic reviews of literature human animal data were conducted assess evidence regarding excess manganese (including authorised salts) priority adverse health effect, i.e. manganese-induced neurotoxicity. Available studies support neurotoxicity as critical however, are not sufficient suitable characterise dose–response relationship identify reference point In absence adequate establish an UL, estimated background dietary intakes (i.e. natural sources only) observed among high consumers (95th percentile) used provide indication highest where there is reasonable confidence effects. A safe 8 mg/day established adults ≥ 18 years pregnant lactating women) ranged between 2 7 other population groups. The application more limited than UL because at which risk effects starts increase defined.

Язык: Английский

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Manganese-induced miR-125b-2-3p promotes anxiety-like behavior via TFR1-mediated ferroptosis

Environmental Pollution, Год журнала: 2023, Номер 344, С. 123255 - 123255

Опубликована: Дек. 28, 2023

Язык: Английский

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Identification of Histone Acetylation Modification Sites in the Striatum of Subchronically Manganese-Exposed Rats

Epigenomics, Год журнала: 2024, Номер 16(1), С. 5 - 21

Опубликована: Янв. 1, 2024

Aim: To explore the specific histone acetylation sites and oxidative stress-related genes that are associated with pathogenesis of manganese toxicity. Methods: We employed liquid chromatography-tandem mass spectrometry bioinformatics analysis to identify acetylated proteins in striatum subchronic manganese-intoxicated rats. Results: identified a total 12 differentially modified sites: H3K9ac, H3K14ac, H3K18ac, H3K56ac H3K79ac were upregulated H3K27ac, H3K36ac, H4K91ac, H4K79ac, H4K31ac, H2BK16ac H2BK20ac downregulated. Additionally, we found CAT, SOD1 SOD2 might be epigenetically regulated involved manganism. Conclusion: This study toxicity, these findings useful search for potential epigenetic targets

Язык: Английский

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The role of metal ions in stroke: current evidence and future perspectives

Ageing Research Reviews, Год журнала: 2024, Номер 101, С. 102498 - 102498

Опубликована: Сен. 6, 2024

Язык: Английский

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Assessment of potentially toxic and mineral elements in paddy soils and their uptake by rice (Oryza sativa L.) with associated health hazards in district Malakand, Pakistan

Heliyon, Год журнала: 2024, Номер 10(7), С. e28043 - e28043

Опубликована: Март 28, 2024

Rice, a primary food source in many countries of the world accumulate potentially harmful elements which pose significant health hazard to consumers. The current study aimed evaluate toxic and mineral both paddy soils rice grains associated with allied risks Malakand, Pakistan. Rice plants intact root soil were randomly collected from fields analyzed for (PTEs) through inductively coupled plasma optical emission spectrometry (ICP‒OES). Through deterministic probabilistic risk assessment models, daily intake PTEs consumption estimated children adults. results pH (<8.5) electrical conductivity (EC > 400 μs/cm), indicated slightly saline nature. mean phosphorus concentration 291.50 (mg/kg) samples exceeded FAO/WHO permissible limits. normalized variation matrix respect Ni (0.05), Ca EC (0.08), Mg (0.09), influence on mobility. In grains, concentrations (463.81), Al (70.40), As (1.23), Cr (12.53), Cu (36.07), Fe (144.32), Mn (13.89), (1.60) safety transfer factor >1 K, Cu, P Zn bioavailability these grains. Monte Carlo simulations index Cr, Zn, As, certainties 89.93% 90.17%, noncarcinogenic adults consumption. total carcinogenic (TCR) USEPA acceptable limits 1.0E-06 1.0E-04, respectively. sensitivity analysis showed that ingestion rate was key factor. Arsenic (As) primarily influenced cancer children, while chromium (Cr) significantly impacted Deterministic values due inherent uncertainties analysis. poses risks, mainly exposure investigated area.

Язык: Английский

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Effects of chronic manganese administration on motor and non-motor disorders similar to Parkinson’s disease in rats: involvement of oxidative stress

Egyptian Journal of Basic and Applied Sciences, Год журнала: 2025, Номер 12(1), С. 169 - 184

Опубликована: Янв. 28, 2025

Язык: Английский

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Relationship between prenatal metals exposure and neurodevelopment in one-year-old infants in the CLIMB study

Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 291, С. 117860 - 117860

Опубликована: Фев. 1, 2025

Prenatal metals exposure and its effects on infant neurodevelopment have garnered significant attention. However, most studies focus individual metals, neglecting combined effects. We aimed to assess the of both single prenatal one-year-old infants' neurodevelopment. This study included 189 mother-infant pairs from Complex Lipids in Mothers Babies (CLIMB) cohort. The concentrations 21 metallic elements 2 metalloids umbilical cord blood (UCB) serum were measured using inductively coupled plasma mass spectrometry (ICP-MS). Neurodevelopment was Chinese version Bayley Scales Infant Development (BSID) for Psychomotor Index (PDI) Mental (MDI). Multiple statistical methods, including linear models, restricted cubic splines (RCS), weighted quantile sum (WQS) regression, Bayesian kernel machine regression (BKMR). After adjusting potential confounders, arsenic (As) strontium (Sr) levels associated with lower PDI scores (As: β = -2.324; 95 % CI: -4.61, -0.04; Sr: -2.426; -4.67, -0.18) by while Sr MDI (β -2.841; -5.44, -0.25). RCS models revealed nonlinear dose-response relationships between manganese (Mn) calcium (Ca) PDI, Mn, As, zirconium (Zr) MDI. Interactions certain also identified. Metals mixture had an overall negative effect scores, Mn being primary contributor. selected or metal mixtures is poorer infants.

Язык: Английский

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Consequences of Dietary Manganese-Based Nanoparticles Supplementation or Deficiency on Systemic Health and Gut Metabolic Dynamics in Rats

Nanotechnology Science and Applications, Год журнала: 2025, Номер Volume 18, С. 19 - 34

Опубликована: Фев. 1, 2025

Trace elements such as manganese (Mn) are essential for various biological processes, including enzyme activation, metabolic pathways, and antioxidant defences. Given its involvement in these critical maintaining adequate Mn levels is crucial overall health. The experimental design involved 24 male Wistar rats divided into three groups (n=8 per group): a control group receiving standard supplementation (65 mg/kg), an Mn-deficient group, supplemented with Mn2O₃ nanoparticles mg/kg). 12-week feeding trial assessed selected physiological parameters, tissue composition, caecal health, biochemical markers. Body major organ weights were not significantly affected across (p=0.083 to p=0.579). However, significant differences observed fat percentage (p=0.016) lean (p<0.001). Caecal parameters showed higher ammonia (p=0.030) increased pH (p=0.031) the nano-Mn group. In turn, total SCFA concentrations highest followed by Enzymatic activities of bacteria differed between groups, reduced activity Blood plasma analysis revealed lower insulin (p<0.001) neurotransmitter levels, dopamine serotonin, compared controls. Our findings suggest that both deficiency can lead alterations, affecting metabolism, gut health microbial enzymatic or highlighting role homeostasis potential implications nutritional pharmaceutical interventions.

Язык: Английский

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