Life Science Alliance,
Год журнала:
2024,
Номер
7(12), С. e202402719 - e202402719
Опубликована: Сен. 20, 2024
PRDM16
is
a
transcription
factor
with
histone
methyltransferase
activity
expressed
at
the
earliest
stages
of
cardiac
development.
Pathogenic
mutations
in
humans
lead
to
cardiomyopathy,
conduction
abnormalities,
and
heart
failure.
specifically
ventricular
but
not
atrial
cardiomyocytes,
its
expression
declines
postnatally.
Because
other
tissues
best
known
for
role
binary
cell
fate
decisions,
we
hypothesized
similar
decision-making
function
cardiomyocytes.
Here,
demonstrated
that
cardiomyocyte-specific
deletion
Prdm16
during
development
results
contractile
dysfunction
abnormal
electrophysiology
postnatal
heart,
resulting
premature
death.
By
combined
RNA+ATAC
single-cell
sequencing,
found
favors
working
cardiomyocyte
identity,
by
opposing
master
regulators
fate.
Myocardial
loss
resulted
hyperplasia
(distal)
system.
Hence,
plays
an
indispensable
driving
identity.
Frontiers in Endocrinology,
Год журнала:
2023,
Номер
14
Опубликована: Фев. 16, 2023
Brown
adipose
tissue
(BAT),
a
thermoregulatory
organ
known
to
promote
energy
expenditure,
has
been
extensively
studied
as
potential
avenue
combat
obesity.
Although
BAT
is
the
opposite
of
white
(WAT)
which
responsible
for
storage,
shares
thermogenic
capacity
with
beige
that
emerges
from
WAT
depots.
This
unsurprising
both
and
display
huge
difference
in
terms
their
secretory
profile
physiological
role.
In
obesity,
content
declines
these
tissues
acquire
characteristics
via
process
called
“whitening”.
rarely
explored
its
implication
whether
it
contributes
or
exacerbates
Emerging
research
demonstrated
BAT/beige
whitening
sophisticated
metabolic
complication
obesity
linked
multiple
factors.
The
current
review
provides
clarification
on
influence
various
factors
such
diet,
age,
genetics,
thermoneutrality,
chemical
exposure
whitening.
Moreover,
defects
mechanisms
underpin
are
described.
Notably,
can
be
marked
by
accumulation
large
unilocular
lipid
droplets,
mitochondrial
degeneration,
collapsed
capacity,
virtue
dysfunction,
devascularization,
autophagy,
inflammation.
Nutrients,
Год журнала:
2023,
Номер
15(9), С. 2229 - 2229
Опубликована: Май 8, 2023
The
increasing
prevalence
of
overweight
and
obesity
suggests
that
current
strategies
based
on
diet,
exercise,
pharmacological
knowledge
are
not
sufficient
to
tackle
this
epidemic.
Obesity
results
from
a
high
caloric
intake
energy
storage,
the
latter
by
white
adipose
tissue
(WAT),
when
neither
counterbalanced
an
equally
expenditure.
As
matter
fact,
research
is
focused
developing
new
increase
Against
background,
brown
(BAT),
whose
importance
has
recently
been
re-evaluated
via
use
modern
positron
emission
techniques
(PET),
receiving
great
deal
attention
institutions
worldwide,
as
its
main
function
dissipate
in
form
heat
process
called
thermogenesis.
A
substantial
reduction
BAT
occurs
during
normal
growth
humans
hence
it
easily
exploitable.
In
recent
years,
scientific
made
strides
investigated
focus
expanding
activating
existing
BAT.
present
review
summarizes
about
various
molecules
can
be
used
promote
white-to-brown
conversion
expenditure
order
assess
potential
role
thermogenic
nutraceuticals.
This
includes
tools
could
represent,
future,
valid
weapon
against
Journal of Clinical Medicine,
Год журнала:
2023,
Номер
12(8), С. 2882 - 2882
Опубликована: Апрель 14, 2023
Mitochondria
are
semiautonomous
doubly
membraned
intracellular
components
of
cells.
The
organelle
comprises
an
external
membrane,
followed
by
coiled
structures
within
the
membrane
called
cristae,
which
further
surrounded
matrix
spaces
space
between
and
internal
organelle.
A
typical
eukaryotic
cell
contains
thousands
mitochondria
it,
make
up
25%
cytoplasm
present
in
cell.
acts
as
a
common
point
for
metabolism
glucose,
lipids,
glutamine.
chiefly
regulate
oxidative
phosphorylation-mediated
aerobic
respiration
TCA
cycle
generate
energy
form
ATP
to
fulfil
cellular
needs.
possesses
unique
supercoiled
stranded
mitochondrial
DNA
(mtDNA)
encodes
several
proteins,
including
rRNA
tRNA
crucial
transport
electrons,
phosphorylation,
initiating
genetic
repair
processors.
Defects
act
principal
factor
chronic
diseases.
dysfunction
can
cause
malfunction
leakage
electron
respiratory
chain,
leading
increase
reactive
oxygen
species
signaling
aberrant
oncogenic
tumor
suppressor
alter
pathways
involved
metabolism,
disrupt
redox
balance,
induce
endurance
towards
apoptosis
treatments
play
major
role
developing
metabolic
conditions.
current
review
presents
knowledge
on
aspects
its
cancer,
diabetes
mellitus,
infections,
obesity.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(24), С. 13438 - 13438
Опубликована: Дек. 15, 2024
The
global
rise
in
obesity
underscores
the
need
for
effective
weight
management
strategies
that
address
individual
metabolic
and
hormonal
variability,
moving
beyond
simplistic
“calories
in,
calories
out”
model.
Body
types—ectomorph,
mesomorph,
endomorph—provide
a
framework
understanding
differences
fat
storage,
muscle
development,
energy
expenditure,
as
each
type
responds
uniquely
to
caloric
intake
exercise.
Variability
outcomes
is
influenced
by
factors
such
genetic
polymorphisms
epigenetic
changes
signaling
pathways
processes,
well
lifestyle
factors,
including
nutrition,
exercise,
sleep,
stress.
These
impact
magnitude
of
lipogenesis
myofibrillar
protein
synthesis
during
overfeeding,
extent
lipolysis
proteolysis
restriction,
through
complex
mechanisms
involve
resting
rate,
pathways,
profiles.
Precision
approaches,
nutrigenomics,
indirect
calorimetry,
artificial-intelligence-based
strategies,
can
potentially
leverage
these
insights
create
individualized
aligned
with
person’s
unique
profile.
By
addressing
personalized
precision
nutrition
offers
promising
pathway
sustainable
outcomes.
main
objective
this
review
examine
adaptations
driving
variability
explore
how
challenges
strategies.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(6), С. 2792 - 2792
Опубликована: Март 20, 2025
The
widespread
use
of
wireless
technologies
has
raised
public
health
concerns
about
the
biological
effects
radiofrequency
(RF)
exposure.
Children
have
a
higher
specific
absorption
rate
(SAR)
radiation
energy
compared
to
adults.
Furthermore,
brown
adipose
tissue
(BAT)
is
more
prevalent
in
infants
and
tends
decrease
with
age.
Previous
animal
studies
demonstrated
cold
sensation
rats
exposed
900
MHz
(second
generation,
2G).
UCP1-dependent
thermogenesis
BAT
hyperplasia
are
two
fundamental
adaptive
mechanisms
initiated
response
cold.
This
study
investigated
impact
short-term
exposure
2G
fifth
generation
(5G)
on
key
thermogenic
adipogenic
markers
related
these
while
considering
age
duration.
Juvenile
young
adult
Wistar
were
randomized
into
three
subgroups:
5G
group
(3.5
GHz),
(900
MHz),
control
(SHAM).
They
their
respective
continuous-wave
RF
signals
for
1
or
2
weeks
at
an
intensity
1.5
V/m,
sessions
h
per
day.
After
period,
RT-qPCR
was
carried
out
evaluate
genetic
involved
adipogenesis.
Two
biomarkers
affected;
fold
change
reduction
49%
32%
detected
PRDM16
(p
=
0.016)
C/EBP
β
0.0002),
respectively,
after
exposure,
regardless
No
significant
effect
found
transcriptional
level.
These
findings
suggest
that
may
partially
disrupt
adipocyte
differentiation
function
by
downregulating
β,
possibly
leading
sensitivity.
