Reviews on Clinical Pharmacology and Drug Therapy,
Год журнала:
2024,
Номер
22(3), С. 237 - 255
Опубликована: Ноя. 13, 2024
This
review
article
focuses
on
the
use
of
violets
and
their
derivatives
as
medicinal
agents.
Special
attention
is
given
to
historical
aspects
using
healing
properties
violets,
well
analysis
substances
derived
from
these
plants
for
pharmaceutical
production.
The
specifically
discusses
oxytocin-like
found
in
particularly
cyclotides.
Cyclotides
are
globular
microproteins
with
a
unique
head-to-tail
cyclized
backbone
stabilized
by
three
disulfide
bonds
forming
cystine
knot.
chemical
characteristics
cyclotides
make
them
suitable
recombinant
scaffolds
design
development
ligands
G
protein-coupled
receptors,
which
part
modern
generation
drugs.
bradykinin
κ-opioid
demand
pharmacology,
described
detail.
Molecules,
Год журнала:
2024,
Номер
29(20), С. 4951 - 4951
Опубликована: Окт. 19, 2024
Peptide-based
inhibitors
represent
a
promising
approach
for
the
treatment
of
HIV-1,
offering
range
potential
advantages,
including
specificity,
low
toxicity,
and
ability
to
target
various
stages
viral
lifecycle.
This
review
outlines
current
state
research
on
peptide-based
anti-HIV
therapies,
highlighting
key
advancements
identifying
future
directions.
Over
past
few
years,
there
has
been
significant
progress
in
developing
synthetic
drugs
that
life
cycle,
entry
replication.
These
approaches
aim
create
effective
therapies.
Additionally,
peptides
have
proven
valuable
development
vaccines.
In
quest
HIV
vaccines,
discovering
potent
antigens
designing
suitable
vaccine
strategies
are
crucial
overcoming
challenges
such
as
immunogenicity,
safety
concerns,
increased
load.
Innovative
through
peptide
are,
therefore,
focus
area
achieving
prevention.
aims
explore
with
activity
highlight
their
role
advancing
both
therapeutic
preventive
measures
against
HIV.
Current Issues in Molecular Biology,
Год журнала:
2024,
Номер
47(1), С. 1 - 1
Опубликована: Дек. 24, 2024
Antimicrobial
peptides
(AMPs)
are
constituent
molecules
of
the
innate
defense
system
and
naturally
produced
by
all
organisms.
AMPs
characterized
a
relatively
low
molecular
weight
(less
than
10
kDa)
variable
number
cysteine
residues
that
form
disulfide
bonds
contribute
to
stabilization
tertiary
structure.
In
addition,
there
is
wide
repertoire
antimicrobial
agents
against
bacteria,
viruses,
fungi,
protozoa
can
provide
large
prototype
for
study
biochemical
manipulation.
this
sense,
plant
stand
out
because
they
have
range
biological
functions
microorganisms
potential
applications
in
medicine
agriculture.
Herein,
we
describe
mini-review
principal
AMP
families,
such
as
defensins,
lipid
transfer
proteins
(LTPs),
thionins,
heveins,
cyclotides.
The
objective
work
was
present
main
discoveries
regarding
activities
these
especially
last
20
years.
We
also
discuss
current
knowledge
their
activities,
gene
expression,
possible
uses
biotechnology.
ACS Infectious Diseases,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 22, 2025
Plants
provide
an
abundant
source
of
potential
therapeutic
agents,
including
a
diverse
array
compounds,
such
as
cyclotides,
which
are
peptides
known
for
their
antimicrobial
activity.
Cyclotides
multifaceted
molecules
with
wide
range
biological
activities.
Their
unique
topology
forms
head-to-tail
cyclic
structure
reinforced
by
cysteine
knot,
confers
chemical
and
thermal
stability.
These
can
directly
target
membranes
infectious
agents
binding
to
phosphatidylethanolamine
in
lipid
membranes,
leading
membrane
permeabilization.
Additionally,
they
function
carriers
cell-penetrating
molecules,
demonstrating
antiviral,
antibacterial,
antifungal,
nematicidal
properties.
The
cyclotides
is
also
amenable
synthesis,
facilitating
drug
design
through
residue
substitutions
or
grafting
bioactive
epitopes
within
the
cyclotide
scaffold
enhance
peptide
In
this
review,
we
explore
multifunctionality
these
biomolecules
anti-infective
emphasizing
novel
class
drugs.
Journal of Clinical Laboratory Analysis,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 14, 2025
ABSTRACT
Background
Sexually
transmitted
infections
(STIs)
are
a
major
threat
to
global
health,
and
the
emergence
of
antibiotic‐resistant
strains
has
made
therapeutic
strategies
more
complex.
Antimicrobial
peptides
(AMPs)
ubiquitous
class
natural
compounds
that
expected
be
an
alternative
conventional
antibiotics
due
their
broad
spectrum
activity
lower
propensity
for
resistance,
promising
alternatives
antibiotics.
Objective
To
emphasize
importance
antimicrobial
in
fight
against
STIs
review
recent
advances
AMPs
treatment
prevention
STIs.
Methods
This
article
focuses
on
reviewing
progress
research
prognosis
such
as
gonorrhea,
HIV,
HPV,
chlamydia,
discusses
challenges
future
directions
field.
Results
have
great
potential
However,
face
enzymatic
degradation,
safety
high
cost,
while
nanotechnology
peptide
modification
enhance
stability
bioavailability
AMPs.
Conclusion
become
important
tool
with
further
technological
innovation.
The
cannabinoid
type
2
receptor
(CB2R),
a
G
protein-coupled
(GPCR),
is
an
important
regulator
of
immune
cell
function
and
promising
target
for
to
treat
chronic
inflammation
fibrosis.
While
CB2R
typically
targeted
by
small
organic
molecules,
including
endo-,
phyto-
synthetic
cannabinoids,
peptides
may
offer
different
interaction
space,
owing
their
larger
size
greater
contact
area
they
facilitate
differential
interactions
with
specific
target.
Here
we
explore
plant-derived
cyclic
cystine-knot
as
ligands
the
CB2R.
Cyclotides
are
known
exceptional
biochemical
stability.
Recently
gained
attention
modulators
GPCR
signaling
templates
designing
peptide
improved
pharmacokinetic
properties
over
linear
peptides.
Cyclotide-based
were
profiled
based
on
peptide-enriched
extract
library
comprising
nine
plant
species.
Employing
pharmacology-guided
fractionation
peptidomics
identified
cyclotide
vodo-C1
from
sweet
violet
(Viola
odorata)
full
agonist
affinity
(Ki)
1
µM
potency
(EC50)
8
µM.
Leveraging
deep
learning
networks
verified
structural
topology
modelled
its
molecular
volume
in
comparison
ligand
binding
pocket.
In
fragment-based
approach
designed
characterized
vodo-C1-based
bicyclic
(vBCL1-4),
aiming
reduce
improve
potency.
Opposite
vodo-C1,
vBCL
lacked
ability
activate
receptor,
but
acted
negative
allosteric
or
neutral
antagonists
This
study
introduces
new
macrocyclic
phytocannabinoid,
which
served
template
development
modulators.
These
findings
opportunities
future
peptide-based
probe
drug
at
receptors.
Regulatory Mechanisms in Biosystems,
Год журнала:
2024,
Номер
15(3), С. 626 - 634
Опубликована: Авг. 19, 2024
The
use
of
herbal
medicines,
due
to
their
wide
therapeutic
spectrum
and
absence
or
minimal
side
effects,
is
an
important
area
therapy
that
used
in
the
treatment
diseases
various
etiologies.
Garden
violet
/wild
pansy
(Viola
tricolor
L.)
a
medicinal
plant
family
widely
distributed
Ukraine.
herb
this
(Violae
herba)
as
official
raw
material,
which
sold
dry
form
independent
remedy
part
teas.
In
study,
we
determined
overall
effect
V.
high-fat
diet
on
body
weight
gain,
metabolic
processes
model
animals,
intestinal
microbiota.
For
experiment,
15
male
white
laboratory
rats
were
divided
into
three
groups
fed
(15%
vegetable
fat)
supplemented
with
0.5%
2.0%
dried
for
30
days.
Consumption
resulted
increased
gain
compared
control
group.
at
dose
caused
increase
relative
brain
large
intestine
(caecum
colon)
decrease
thymus.
At
2.0%,
thymus
caecum
increased,
but
colon
decreased,
length
rectum
decreased
globulin
concentration
changes
protein
ratio,
–
total
protein,
albumin,
albumin/globulin
ratio
level.
addition
high-density
lipoprotein
(HDL)
cholesterol
2.0%.
Regardless
dose,
contributed
reduction
plasma
atherogenic
index.
Both
doses
sharp
significant
De
Ritis
alkaline
phosphatase
activity.
Adding
helps
maintain
quantitative
composition
main
microbiota
(Bifidobacterium,
Lactobacillus
typical
Escherichia
coli).
It
was
found
2%
had
bacteriostatic
low-fermenting
coli
Klebsiella
spp.
bactericidal
Enterococcus
spp.,
can
disrupt
normal
functions
cause
diseases.
Planta Medica,
Год журнала:
2023,
Номер
89(15), С. 1493 - 1504
Опубликована: Сен. 25, 2023
Viola
tricolor
is
a
medicinal
plant
with
documented
application
as
an
anti-inflammatory
herb.
The
standard
of
care
for
the
treatment
inflammatory
bowel
disease
immunosuppressive
therapeutics
or
biologics,
which
often
have
undesired
effects.
We
explored
V.
herbal
preparations
that
are
rich
in
emerging
class
phytochemicals
drug-like
properties,
so-called
cyclotides.
As
alternative
to
existing
medications,
cyclotides
immunomodulatory
and
their
intrinsic
stability
allows
gastrointestinal
tract,
instance,
via
oral
administration.
optimized
isolation
procedure
improve
yield
compared
cellular
effects
violet-derived
organic
solvent-extracts,
aqueous
preparations,
isolated
cyclotide
from
this
on
primary
human
T
lymphocytes
macrophages,
i.e.,
cells
crucial
initiation
progression
disease.
hot
water
decoctions
stronger
activity
towards
proliferation,
interferon-γ,
interleukin-21
secretion
than
DCM/MeOH
cyclotide-enriched
extract,
kalata
S
appears
one
active
components
responsible
observed
This
effect
was
increased
by
longer
boiling
duration.
In
contrast,
extract
more
effective
reducing
levels
cytokines
interleukin-6,
interleukin-12,
interleukin-23,
tumor
necrosis
factor-α,
C
-
X-C
motif
chemokine
ligand
10,
secreted
monocyte-derived
macrophages.
Defined
promising
pharmacological
modulating
immune
cell
responses
at
cytokine
levels.
important
understanding
role
cyclotide-containing
drug
future
applications
disorders,
such
Journal of Biological Chemistry,
Год журнала:
2024,
Номер
300(6), С. 107330 - 107330
Опубликована: Апрель 26, 2024
The
cannabinoid-type
2
receptor
(CB2R),
a
G
protein-coupled
(GPCR),
is
an
important
regulator
of
immune
cell
function
and
promising
target
to
treat
chronic
inflammation
fibrosis.
While
CB2R
typically
targeted
by
small
molecules,
including
endo-,
phyto-
synthetic
cannabinoids,
peptides
–
owing
their
size
may
offer
different
interaction
space
facilitate
differential
interactions
with
the
receptor.
Here
we
explore
plant-derived
cyclic
cystine-knot
as
ligands
CB2R.
Cyclotides
are
known
for
exceptional
biochemical
stability.
Recently
they
gained
attention
GPCR
modulators
templates
designing
peptide
improved
pharmacokinetic
properties
over
linear
peptides.
Cyclotide-based
were
profiled
based
on
peptide-enriched
extract
library
comprising
nine
plants.
Employing
pharmacology-guided
fractionation
peptidomics
identified
cyclotide
vodo-C1
from
sweet
violet
(Viola
odorata)
full
agonist
affinity
(Ki)
1μM
potency
(EC50)
8μM.
Leveraging
deep
learning
networks
verified
structural
topology
modelled
its
molecular
volume
in
comparison
ligand
binding
pocket.
In
fragment-based
approach
designed
characterized
vodo-C1-based
bicyclic
(vBCL1-4),
aiming
reduce
improve
potency.
Opposite
vodo-C1,
vBCL
lacked
ability
activate
but
acted
negative
allosteric
or
neutral
antagonists
This
study
introduces
macrocyclic
phytocannabinoid,
which
served
template
development
modulators.
These
findings
opportunities
future
peptide-based
probe
drug
at
cannabinoid
receptors.
