Pediatric Blood & Cancer, Год журнала: 2025, Номер unknown
Опубликована: Янв. 21, 2025
Язык: Английский
Drug Resistance Updates, Год журнала: 2022, Номер 66, С. 100916 - 100916
Опубликована: Дек. 29, 2022
Язык: Английский
Процитировано
179
Advanced Science, Год журнала: 2023, Номер 10(24)
Опубликована: Июнь 21, 2023
Emerging evidence suggests that ferroptosis, a unique regulated cell death modality is morphologically and mechanistically different from other forms of death, plays vital role in the pathophysiological process neurodegenerative diseases, strokes. Accumulating supports ferroptosis as critical factor diseases strokes, pharmacological inhibition therapeutic target for these diseases. In this review article, core mechanisms are overviewed roles strokes described. Finally, emerging findings treating through This demonstrates by bioactive small-molecule compounds (ferroptosis inhibitors) could be effective treatments highlights potential promising avenue used to prevent article will shed light on developing novel regimens slow down progression future.
Язык: Английский
Процитировано
92
Signal Transduction and Targeted Therapy, Год журнала: 2023, Номер 8(1)
Опубликована: Дек. 10, 2023
Abstract Ferroptosis, a unique modality of cell death with mechanistic and morphological differences from other modes, plays pivotal role in regulating tumorigenesis offers new opportunity for modulating anticancer drug resistance. Aberrant epigenetic modifications posttranslational (PTMs) promote resistance, cancer progression, metastasis. Accumulating studies indicate that can transcriptionally translationally determine vulnerability to ferroptosis functions as driver nervous system diseases (NSDs), cardiovascular (CVDs), liver diseases, lung kidney diseases. In this review, we first summarize the core molecular mechanisms ferroptosis. Then, roles processes, including histone PTMs, DNA methylation, noncoding RNA regulation such phosphorylation, ubiquitination, SUMOylation, acetylation, ADP-ribosylation, are concisely discussed. The PTMs genesis cancers, NSD, CVDs, well application PTM modulators therapy these then discussed detail. Elucidating mediated by will facilitate development promising combination therapeutic regimens containing or PTM-targeting agents inducers be used overcome chemotherapeutic resistance could prevent addition, highlight potential approaches chemoresistance halt
Язык: Английский
Процитировано
84
International Journal of Biological Sciences, Год журнала: 2023, Номер 19(12), С. 3726 - 3743
Опубликована: Янв. 1, 2023
Ferroptosis is an iron-dependent programmed cell death pattern that characterized by iron overload, reactive oxygen species (ROS) accumulation and lipid peroxidation. Growing viewpoints support the imbalance of homeostasis disturbance metabolism contribute to tissue or organ injury in various kidney diseases triggering ferroptosis. At present, key regulators complicated network mechanisms associated with ferroptosis have been deeply studied; however, its role initiation progression has not fully revealed. Herein, we aim discuss features, ferroptosis, explore emerging roles organelles gather pharmacological progress, systematically summarize most recent discoveries about crosstalk between diseases, including renal carcinoma (RCC), acute (AKI), diabetic disease (DKD), autosomal dominant polycystic (ADPKD), fibrosis, lupus nephritis (LN) IgA nephropathy. We further conclude potential therapeutic strategies targeting for prevention treatment hope this work will provide insight study pathogenesis kidney-related diseases.
Язык: Английский
Процитировано
36
Journal of Molecular Biology, Год журнала: 2023, Номер 435(12), С. 168144 - 168144
Опубликована: Май 13, 2023
The elucidation of the function PINK1 protein kinase and Parkin ubiquitin E3 ligase in elimination damaged mitochondria by autophagy (mitophagy) has provided unprecedented understanding mechanistic pathways underlying Parkinson's disease (PD). We provide a comprehensive overview general importance related disorders central nervous system. This reveals critical link between neurodegenerative neurodevelopmental suggests that strategies to modulate mitophagy may have greater relevance CNS beyond PD.
Язык: Английский
Процитировано
31
Cell Death and Disease, Год журнала: 2023, Номер 14(9)
Опубликована: Сен. 22, 2023
Abstract Kidney diseases remain one of the leading causes human death and have placed a heavy burden on medical system. Regulated cell contributes to pathology plethora renal diseases. Recently, with in-depth studies into kidney death, new iron-dependent modality, known as ferroptosis, has been identified attracted considerable attention among researchers in pathogenesis therapeutics treat them. The majority suggest that ferroptosis plays an important role pathologies multiple diseases, such acute injury (AKI), chronic disease, carcinoma. In this review, we summarize recently regulatory molecular mechanisms discuss pathways action various describe protective effect inhibitors against especially AKI. By summarizing prominent roles different progress made studying provide directions strategies for future research summary, ferroptotic factors are potential targets therapeutic intervention alleviate targeting them may lead treatments patients
Язык: Английский
Процитировано
28
Oncology Reports, Год журнала: 2023, Номер 49(2)
Опубликована: Янв. 13, 2023
Polypyrimidine tract‑binding protein 1 (PTBP1) plays an important role in tumor immunity, cell proliferation, apoptosis, and autophagy by regulating RNA metabolism. However, the specific function mechanism of PTBP1 ferroptosis remain unclear. In present study, it was investigated whether regulates exact mechanism. The iron, malondialdehyde (MDA), GSH levels were detected sorafenib (SF)‑treated liver cancer cells. si‑PTBP1 introduction into SF‑treated cells resulted a significant reduction MDA iron. Additionally, recovery observed after silencing PTBP1. StarBase v2.0 database used to predict potential transcripts that can physically interact with nuclear receptor coactivator 4 (NCOA4) mRNA identified as most enriched binding partner PTBP1‑RNA complex. A dual‑luciferase assay then demonstrated directly interacted NCOA4. did not affect NCOA4 stability following treatment cycloheximide. pull‑down revealed PTBP1‑binding region 5'‑UTR sequence. These results suggest mediates translation. vivo experiments reconfirmed PTBP1‑NCOA4 axis xenograft transplantation model. It mean weight increased knockout. conclusion, decreased sensitivity SF regulated ferritinophagy mediating
Язык: Английский
Процитировано
18
Frontiers in Pharmacology, Год журнала: 2023, Номер 14
Опубликована: Апрель 13, 2023
Cardiomyopathies are a clinically heterogeneous group of cardiac diseases characterized by heart muscle damage, resulting in myocardium disorders, diminished function, failure, and even sudden death. The molecular mechanisms underlying the damage to cardiomyocytes remain unclear. Emerging studies have demonstrated that ferroptosis, an iron-dependent non-apoptotic regulated form cell death iron dyshomeostasis lipid peroxidation, contributes development ischemic cardiomyopathy, diabetic doxorubicin-induced septic cardiomyopathy. Numerous compounds exerted potential therapeutic effects on cardiomyopathies inhibiting ferroptosis. In this review, we summarize core mechanism which ferroptosis leads these cardiomyopathies. We emphasize emerging types can inhibit delineate their beneficial treating This review suggests pharmacologically may be strategy for cardiomyopathy treatment.
Язык: Английский
Процитировано
18
Biology, Год журнала: 2024, Номер 13(2), С. 103 - 103
Опубликована: Фев. 6, 2024
Oral squamous cell carcinoma (OSCC) is the most common and lethal type of head neck cancer in world. Variable response acquisition resistance to traditional therapies show that it essential develop novel strategies can provide better outcomes for patient. Understanding cellular molecular mechanisms death control has increased rapidly recent years. Activation pathways, such as emerging forms non-apoptotic programmed death, including ferroptosis, pyroptosis, necroptosis, NETosis, parthanatos, mitoptosis paraptosis, may represent clinically relevant therapeutic opportunities. This systematic review summarizes recently described OSCC, highlighting their potential informing diagnosis, prognosis treatment. Original studies explored any selected deaths OSCC were included. Electronic search, study selection, data collection risk bias assessment tools realized. The literature search was carried out four databases, extracted from 79 articles categorized grouped by death. Ferroptosis, necroptosis represented main studies, with links immunity inflammatory responses, progression OSCC. Harnessing these pathways be useful patient-specific individualized therapy. We perspectives on how different types integrated decision prognosis, treatment
Язык: Английский
Процитировано
8
Cells, Год журнала: 2025, Номер 14(5), С. 351 - 351
Опубликована: Фев. 28, 2025
Human immunodeficiency virus (HIV) infection continues to be a major global health challenge, affecting 38.4 million according the Joint United Nations Program on HIV/AIDS (UNAIDS) at end of 2021 with 1.5 new infections. New HIV infections increased during 2 years after COVID-19 pandemic. Understanding intricate cellular processes underlying pathogenesis is crucial for developing effective therapeutic strategies. Among these processes, autophagy and programmed cell death modalities, including apoptosis, necroptosis, pyroptosis, ferroptosis, play pivotal roles in host-virus interaction dynamics. Autophagy, highly conserved mechanism, acts as double-edged sword infection, influencing viral replication, immune response modulation, fate infected cells. Conversely, critical defense mechanism against spread contributes depletion CD4+ T cells, hallmark progression. This review aims dissect complex interplay between modalities HIV-induced pathogenesis. It highlights molecular mechanisms involved, their persistence dysfunction, challenges posed by reservoir drug resistance, which continue impede management pathology. Targeting pathways holds promise novel strategies mitigate chronic inflammation, ultimately improving outcomes individuals living HIV.
Язык: Английский
Процитировано
1