Ferroptosis and oral squamous cell carcinoma: connecting the dots to move forward

Frontiers in Oral Health, Год журнала: 2024, Номер 5

Опубликована: Сен. 4, 2024

Oral squamous cell carcinoma (OSCC) is an aggressive disease whose incomplete biological comprehension contributes to the inappropriate clinical management and poor prognosis. Thus, identification of new promising molecular targets treat OSCC paramount importance. Ferroptosis a regulated death caused by iron-dependent accumulation reactive oxygen species consequent oxidative damage lipid membranes. Over last five years, growing number studies has reported that sensitive ferroptosis induction inducers exert remarkable antitumor effect in OSCC, even those displaying low response common approaches, such as chemotherapy radiotherapy. In addition, considered immunogenic death, it may modulate immune against OSCC. this review, we summarize so far identified regulatory mechanisms prognostic models based on ferroptosis-related genes discuss perspective inducing novel strategy directly or, alternatively, improve sensitivity other approaches. Finally, integrate data emerging from research studies, reviewed here, through silico analysis provide personal potential interconnection between autophagy

Язык: Английский

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Iron Homeostasis and Neurodegeneration in the Aging Brain: Insight into Ferroptosis Pathways

Ageing Research Reviews, Год журнала: 2024, Номер 102, С. 102575 - 102575

Опубликована: Ноя. 7, 2024

Язык: Английский

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Role of liensinine in sensitivity of activated macrophages to ferroptosis and in acute liver injury

Cell Death Discovery, Год журнала: 2023, Номер 9(1)

Опубликована: Июнь 23, 2023

Acute liver injury (ALI) is an acute inflammatory disease with a high mortality rate. Alternatively, activated macrophages (AAMs) have been linked to the inflammation and recovery of ALI. However, mechanism underlying AAM death in ALI has not studied sufficiently. We used liensinine (Lie) as drug choice after screening library small-molecule monomers 1488 compounds from traditional Chinese remedies. In ALI, we evaluated potential therapeutic effects mechanisms action found that it effectively inhibited RSL3-induced ferroptosis AAM. Lie significantly reduced lipid peroxidation RSL3-generated It also improved survival rate LPS/D-GalN-treated mice, serum transaminase activity, suppressed factor production, may lowered ferritinophagy blocked Fe2+ synthesis. Following combined treatment RSL3 Lie, super-resolution microscopy revealed close correlation between ferritin LC3-positive vesicles The co-localization LC3 LAMP1 was reduced. These findings suggest ameliorate by inhibiting enhancing AMM resistance autophagosome-lysosome fusion. Therefore, be agent for patients

Язык: Английский

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The mechanisms crosstalk and therapeutic opportunities between ferroptosis and ovary diseases

Frontiers in Endocrinology, Год журнала: 2023, Номер 14

Опубликована: Июль 26, 2023

Ferroptosis, a form of regulated cell death, was first defined in 2012. Ferroptosis mainly involves iron-driven lipid peroxidation damage cells. This process is by iron homeostasis, redox balance, metabolism, glutathione and various disease signaling pathways. Iron one the key mineral elements that regulate physiological function women development ovarian tumors. Occurrence has some hidden dangers advantages ovary diseases. Some scholars have shown ferroptosis granulosa cells (GC) promotes dysfunction polycystic syndrome (PCOS). Interestingly, drug-resistant cancer are very sensitive to ferroptosis, suggesting pharmacological positive negative regulation great potential treatment benign diseases cancer. article aimed assess how occurs factors controlling ferroptosis. Moreover, we summarize can be used predict, diagnose target disease. Meanwhile, also evaluated different phenomena It aims provide new directions for research prevention female reproductive

Язык: Английский

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Expanding the Concept of Iron Deficiency Using a Mitochondrial Metabolic Approach: Explaining and Preventing Sudden Death

Pediatric Blood & Cancer, Год журнала: 2025, Номер unknown

Опубликована: Янв. 21, 2025

Язык: Английский

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