Depression and Its Phytopharmacotherapy—A Narrative Review

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(5), С. 4772 - 4772

Опубликована: Март 1, 2023

Depression is a mental health disorder that develops as result of complex psycho-neuro-immuno-endocrinological disturbances. This disease presents with mood disturbances, persistent sadness, loss interest and impaired cognition, which causes distress to the patient significantly affects ability function have satisfying family, social professional life. requires comprehensive management, including pharmacological treatment. Because pharmacotherapy depression long-term process associated risk numerous adverse drug effects, much attention paid alternative therapy methods, phytopharmacotherapy, especially in treating mild or moderate depression. Preclinical studies previous clinical confirm antidepressant activity active compounds plants, such St. John’s wort, saffron crocus, lemon balm lavender, less known European ethnopharmacology, roseroot, ginkgo, Korean ginseng, borage, brahmi, mimosa tree magnolia bark. The these plants exert antidepressive effects similar mechanisms those found synthetic antidepressants. description phytopharmacodynamics includes inhibiting monoamine reuptake oxidase complex, agonistic antagonistic on multiple central nervous system (CNS) receptors. Moreover, it noteworthy anti-inflammatory effect also important mentioned above light hypothesis immunological disorders CNS are significant pathogenetic factor narrative review results from traditional, non-systematic literature review. It briefly discusses pathophysiology, symptomatology treatment depression, particular focus role phytopharmacology its provides action revealed experimental ingredients isolated herbal antidepressants selected confirming their effectiveness.

Язык: Английский

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Efficacy of empagliflozin as adjunctive therapy to citalopram in major depressive disorder: a randomized double-blind, placebo-controlled clinical trial

BMC Psychiatry, Год журнала: 2024, Номер 24(1)

Опубликована: Фев. 26, 2024

Abstract Background Major depressive disorder is one of the most common psychiatric disorders, which associated with a high disease burden. Current treatments using antidepressants have limitations, so medication neuromodulating and anti-inflammatory properties alongside them could be helpful. In clinical trial, we studied effectiveness empagliflozin, blood sugar-lowering drug, as an adjunctive therapy to reduce severity depression symptoms. Methods A number outpatients moderate severe (Hamilton Depression Rating Scale (HDRS) > = 17) who were not under related or had taken for at least last two months, age range 18–60 years written informed consent enter study ( N 90) randomly divided into groups receiving placebo empagliflozin (10 mg daily) combined citalopram (40 based on permuted block randomization method in 8-week randomized, double-blind, placebo-controlled trial. They evaluated HDRS weeks 0, 4, 8. Results scores equal 28.42(± 3.83), 20.20(± 3.82), 13.42(± 3.42) group during 0,4, 8, respectively. These 27.36(± 3.77), 13.76(± 1.40), 7.00(± 1.13), respectively, treated empagliflozin. Compared control group, patients repeated-measures ANOVA showed greater improvement reducing symptoms over time p value 0.0001). Conclusions Considering promising findings this further MDD larger sample sizes longer follow-ups recommended.

Язык: Английский

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Honokiol and magnolol: A review of structure-activity relationships of their derivatives

Phytochemistry, Год журнала: 2024, Номер 223, С. 114132 - 114132

Опубликована: Май 5, 2024

Язык: Английский

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A comprehensive review of anti-cancer mechanisms of polyphenol honokiol and nano carrier-based approaches to enhance its therapeutic potential

Phytochemistry Reviews, Год журнала: 2025, Номер unknown

Опубликована: Март 12, 2025

Язык: Английский

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Influence of microorganisms on flavor substances and functional components of sojae semen praeparatum during fermentation: A study integrating comparative metabolomics and high-throughput sequencing

Food Research International, Год журнала: 2024, Номер 187, С. 114405 - 114405

Опубликована: Апрель 25, 2024

Язык: Английский

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Schaftoside Reduces Depression- and Anxiogenic-like Behaviors in Mice Depression Models

Brain Sciences, Год журнала: 2025, Номер 15(3), С. 238 - 238

Опубликована: Фев. 24, 2025

Background: Major depressive disorder is a common mental health issue characterized by persistently low mood and high morbidity mortality. The major pathophysiology neuroinflammation, as evidenced elevated cytokine levels. Patients often fail to achieve full remission with the use of currently available antidepressants, prompting search for new treatment options. Schaftoside (SS), flavonoid found in traditional Chinese herbs, has both antioxidant anti-inflammatory properties. However, its antidepressant effects are poorly understood. Methods: Male C57BL/6 mice underwent chronic unpredictable mild stress (CUMS) lipopolysaccharide (LPS) induce depression- anxiety-like behaviors. SS was administered at 40, 80, 160 mg/kg 28 days. effect on depression-like behaviors assessed using behavioral assays, ELISA used measure pro-inflammatory cytokines serum hippocampus. Results: significantly decreased immobility forced swim tail suspension tests, increased sucrose preference test, reduced feeding latency novelty-suppressed test. These findings indicate improved depression showed that lowered interleukin-1 beta (IL-1β), IL-6, tumor necrosis factor-alpha levels hippocampus CUMS mice. Conclusions: Our study indicates anxiolytic effects, possibly through neuroinflammatory processes, making it promising therapeutic candidate depression, thus deserves further investigation into mechanisms clinical efficacy.

Язык: Английский

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The Effect of mitochondrial-associated endoplasmic reticulum membranes (MAMs) modulation: New insights into therapeutic targets for depression

Neuroscience & Biobehavioral Reviews, Год журнала: 2025, Номер unknown, С. 106087 - 106087

Опубликована: Март 1, 2025

Язык: Английский

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Targeting the CD44 receptor with hyaluronic acid-modified SWCNTs for 17-hydroxy-jolkinolide B delivery to inhibit breast cancer metastasis

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 143260 - 143260

Опубликована: Апрель 1, 2025

Язык: Английский

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Unravelling the role of Interleukin-12 in Neuroinflammatory mechanisms: Pathogenic pathways linking Neuroinflammation to neuropsychiatric disorders

International Immunopharmacology, Год журнала: 2025, Номер 156, С. 114654 - 114654

Опубликована: Апрель 27, 2025

Язык: Английский

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Deciphering the polypharmacology of Dingzhi Xiaowan against comorbid depression: Integrated metabolomics of brain tissue and network pharmacology analysis in chronic restraint stress (CRS)-LPS model

Journal of Ethnopharmacology, Год журнала: 2025, Номер unknown, С. 119960 - 119960

Опубликована: Май 1, 2025

Язык: Английский

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