Kaempferol promotes flap survival by inhibiting ferroptosis and inflammation through network pharmacology and in vivo experiments DOI Open Access
An Wang, Jialong Yang, Jiapeng Deng

и другие.

Wound Repair and Regeneration, Год журнала: 2024, Номер 33(1)

Опубликована: Дек. 24, 2024

Abstract Skin flap transplantation is a primary method for wound repair; however, postoperative skin necrosis remains significant challenge. Kaempferol, flavonol abundant in various foods, exhibits diverse pharmacological effects. This study investigated the potential targets of kaempferol treating ischemia–reperfusion (I/R) injury through network pharmacology and molecular docking, followed by vivo validation. Using SwissTargetPredict, PubChem, SymMap V2, GeneCards databases, 174 target proteins were identified. KEGG GO enrichment analyses, performed using R software, indicated that promotes survival modulating ferroptosis, TNF‐α, NF‐κB signalling pathways. Molecular docking demonstrated stable binding between key proteins, including SIRT1 NRF2. In vivo, McFarlane model was established Sprague–Dawley rats. Kaempferol treatment improved survival, enhanced perfusion areas distal arteriole visualisation, increased blood flow flap. Furthermore, reduced neutrophil infiltration, alleviated oxidative stress, mitochondrial morphology function, inhibited release proinflammatory cytokines. Western blot immunofluorescence analyses confirmed ferroptosis inflammation while promoting survival. Mechanistically, found to activate SIRT1‐mediated HMGB1/TLR4/NF‐κB NRF2/SLC7A11/GPX4 pathways, thereby mitigating I/R injury.

Язык: Английский

Ginsenoside Rd: A promising target for ischemia-reperfusion injury therapy (A mini review) DOI Open Access

Qiupeng Feng,

Lijing Ling,

Yuan Hua

и другие.

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 171, С. 116111 - 116111

Опубликована: Янв. 5, 2024

Ischemia-reperfusion injury (IRI) represents a prevalent pathological phenomenon. Traditional treatment approaches primarily aim at restoring blood supply to ischemic organs, disregarding the consequent damage caused by IRI. Belonging class of protopanaxadiol ginsenosides that are found in Panax ginseng, ginsenoside Rd (GSRd) demonstrates notable safety alongside diverse range biological functions. Its active components exhibit pharmacological effects, encompassing anti-inflammatory, anti-tumor, neuroprotective, cardiovascular-protective, and immune-regulatory properties, making it promising candidate for addressing multiple medical conditions. GSRd shields against I/R employing crucial cellular mechanisms, including attenuation oxidative stress, reduction inflammation, promotion cell survival signaling pathways, inhibition apoptotic pathways. Additionally, regulates mitochondrial function, maintains calcium homeostasis, modulates expression genes involved injury. This review seeks consolidate mechanism action within context Our objective is contribute advancement GSRd-related pharmaceuticals provide novel insights clinicians developing IRI strategies.

Язык: Английский

Процитировано

7
Curcumin mitigates heatstroke-induced myocardial injury by modulating the Akt/Bad/Caspase-3 pathway DOI

Yizhan Wu,

Fei Guo,

Ya Liu

и другие.

Biochemical and Biophysical Research Communications, Год журнала: 2025, Номер unknown, С. 151653 - 151653

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

1
Curcumin nanopreparations: recent advance in preparation and application DOI
Yan Liu, Rui Yin, Yuan Tian

и другие.

Biomedical Materials, Год журнала: 2024, Номер 19(5), С. 052009 - 052009

Опубликована: Авг. 27, 2024

Abstract Curcumin is a natural polyphenolic compound extracted from turmeric with antibacterial, antioxidant, antitumor, preventive and therapeutic neurological disorders variety of bioactivities, which widely used in the field food medicine. However, drawbacks curcumin such as poor aqueous solubility stability have limited practical application curcumin. To overcome these defects enhance its functional properties, various nanoscale systems (liposomes, polymer nanoparticles, protein solid lipid metal etc) been extensively employed for encapsulation delivery. Despite rapid development nanoformulations, there lack comprehensive reviews on their preparation properties. This review provides an overview construction nano-delivery systems, mechanisms action, nanocarrier methods applications nanocarriers pharmaceutical fields to provide theoretical basis technological support efficient bio-utilization, product early clinical

Язык: Английский

Процитировано

6
Erythropoietin alleviates lung ischemia-reperfusion injury by activating the FGF23/FGFR4/ERK signaling pathway DOI Creative Commons
Xiaosheng Jin,

Weijing Jin,

Guoping Li

и другие.

PeerJ, Год журнала: 2024, Номер 12, С. e17123 - e17123

Опубликована: Март 27, 2024

Background The purpose of the present study was to investigate effect erythropoietin (EPO) on lung ischemia-reperfusion injury (LIRI). Methods Sprague Dawley rats and BEAS-2B cells were employed construct an (I/R)-induced model in vivo vitro , respectively. Afterward, I/R tert-butyl hydroperoxide (TBHP)-induced treated with different concentrations EPO. Furthermore, 40 patients LIRI healthy controls enrolled study. Results It observed that tissue damage, cell apoptosis expression BAX caspase-3 higher than control group, nevertheless, Bcl-2, FGF23 FGFR4 level lower group. EPO administration significantly reduced damage while also up-regulating FGFR4. Rescue experiments indicated exerted a protective role associated FGF23/FGFR4/p-ERK1/2 signal pathway. Notably, serum EPO, FGF23, Bcl-2 decreased LIRI, higher. Conclusion could effectively improve which might be related activation signaling

Язык: Английский

Процитировано

3
Curcumin and gallic acid have a synergistic protective effect against ovarian surface epithelium and follicle reserve damage caused by autologous intraperitoneal ovary transplantation in rats DOI
Kübra Başol Baki, Tansel Sapmaz, Kübra Şevgin

и другие.

Pathology - Research and Practice, Год журнала: 2024, Номер 258, С. 155320 - 155320

Опубликована: Апрель 23, 2024

Язык: Английский

Процитировано

3
Prolonged curcumin supplementation causes tissue-specific antioxidant responses in adult oysters: potential implications for resilience against abiotic and biotic stressors in the aquaculture industry DOI
Heloísa Bárbara Gabe,

Karine Amabile Taruhn,

Danielle F. Mello

и другие.

Aquatic Toxicology, Год журнала: 2025, Номер 280, С. 107282 - 107282

Опубликована: Фев. 6, 2025

Язык: Английский

Процитировано

0
The Janus face of HIF-1α in ischemic stroke and the possible associated pathways DOI
Nashwa Amin,

Irum Naz Abbasi,

Fei Wu

и другие.

Neurochemistry International, Год журнала: 2024, Номер 177, С. 105747 - 105747

Опубликована: Апрель 22, 2024

Язык: Английский

Процитировано

3
Effects and Mechanisms of Fisetin against Ischemia-reperfusion Injuries: A Systematic Review DOI

Omid-Ali Adeli,

Saeid Heidari-Soureshjani, Sahar Rostamian

и другие.

Current Pharmaceutical Biotechnology, Год журнала: 2024, Номер 25(16), С. 2138 - 2153

Опубликована: Фев. 4, 2024

Ischemia-reperfusion injury (IRI) is a well-known ailment that can disturb organ function.

Язык: Английский

Процитировано

2
Curcumin Nanoemulgel: Characterization, Optimization, and Evaluation of Photoprotective Efficacy, Anti-Inflammatory Properties, and Antibacterial Activity DOI
Amir Mohammad Bagheri, Mehdi Ranjbar, Somayyeh Karami‐Mohajeri

и другие.

Journal of Cluster Science, Год журнала: 2024, Номер 35(7), С. 2253 - 2272

Опубликована: Июль 12, 2024

Язык: Английский

Процитировано

2
Kaempferol promotes flap survival by inhibiting ferroptosis and inflammation through network pharmacology and in vivo experiments DOI Open Access
An Wang, Jialong Yang, Jiapeng Deng

и другие.

Wound Repair and Regeneration, Год журнала: 2024, Номер 33(1)

Опубликована: Дек. 24, 2024

Abstract Skin flap transplantation is a primary method for wound repair; however, postoperative skin necrosis remains significant challenge. Kaempferol, flavonol abundant in various foods, exhibits diverse pharmacological effects. This study investigated the potential targets of kaempferol treating ischemia–reperfusion (I/R) injury through network pharmacology and molecular docking, followed by vivo validation. Using SwissTargetPredict, PubChem, SymMap V2, GeneCards databases, 174 target proteins were identified. KEGG GO enrichment analyses, performed using R software, indicated that promotes survival modulating ferroptosis, TNF‐α, NF‐κB signalling pathways. Molecular docking demonstrated stable binding between key proteins, including SIRT1 NRF2. In vivo, McFarlane model was established Sprague–Dawley rats. Kaempferol treatment improved survival, enhanced perfusion areas distal arteriole visualisation, increased blood flow flap. Furthermore, reduced neutrophil infiltration, alleviated oxidative stress, mitochondrial morphology function, inhibited release proinflammatory cytokines. Western blot immunofluorescence analyses confirmed ferroptosis inflammation while promoting survival. Mechanistically, found to activate SIRT1‐mediated HMGB1/TLR4/NF‐κB NRF2/SLC7A11/GPX4 pathways, thereby mitigating I/R injury.

Язык: Английский

Процитировано

2