Redox homeostasis in cardiac fibrosis: Focus on metal ion metabolism

Redox Biology, Год журнала: 2024, Номер 71, С. 103109 - 103109

Опубликована: Март 1, 2024

Cardiac fibrosis is a major public health problem worldwide, with high morbidity and mortality, affecting almost all patients heart disease worldwide. It characterized by fibroblast activation, abnormal proliferation, excessive deposition, distribution of extracellular matrix (ECM) proteins. The maladaptive process cardiac complex often involves multiple mechanisms. With the increasing research on fibrosis, redox has been recognized as an important part remodeling, imbalance in homeostasis can adversely affect function structure heart. metabolism metal ions essential for life, cells impair variety biochemical processes, especially redox. However, current ion still very limited. This review comprehensively examines effects (iron, copper, calcium, zinc) metabolism-mediated outlines possible therapeutic interventions, addresses ongoing challenges this rapidly evolving field.

Язык: Английский

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Quercitrin improves cardiac remodeling following myocardial infarction by regulating macrophage polarization and metabolic reprogramming

Phytomedicine, Год журнала: 2024, Номер 127, С. 155467 - 155467

Опубликована: Фев. 19, 2024

The death and disability caused by myocardial infarction is a health problem that needs to be addressed worldwide, poor cardiac repair fibrosis after seriously affect patient recovery. Postmyocardial M2 macrophages of great significance for ventricular remodeling. Quercitrin (Que) common flavonoid in fruits vegetables has antioxidant, anti-inflammatory, antitumor other effects, but whether it role the treatment unclear. In this study, we constructed mouse model administered Que. We found through ultrasound Que administration improved ejection fraction reduced Staining heart sections detection marker protein levels revealed slowed infarction. Flow cytometry showed proportion was increased expression macrophage markers were Que-treated group. Finally, identified metabolomics reduces glycolysis, increases aerobic phosphorylation, alters arginine metabolic pathways, polarizing toward phenotype. Our research lays foundation future application cardiovascular diseases.

Язык: Английский

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Nitro-oleic acid alleviates inflammation and fibrosis by regulating macrophage polarization and fibroblast activation to improve cardiac function in MI mice

International Immunopharmacology, Год журнала: 2025, Номер 146, С. 113710 - 113710

Опубликована: Янв. 1, 2025

Chronic heart failure, caused by myocardial fibrosis after acute infarction (AMI), remains a serious clinical problem that needs urgent resolution. Nitro-oleic acid (OA-NO2), an electrophilic nitro-fatty found in human plasma, is believed to regulate various pathophysiological functions, particularly anti-inflammation and anti-fibrosis. However, the role of OA-NO2 AMI unexplored. Thus, our aim was investigate whether could ameliorate post-myocardial fibrosis, improve cardiac function, elucidate its mechanism mice. In vivo experiments involved constructing mice model administering via subcutaneous osmotic minipumps. Echocardiography transmission electron microscope indicated can alleviate injury systolic function. Transcriptomics tissue suggested improved fibrosis. Immunohistochemistry qPCR results demonstrated OA-NO2's reduction accumulation extracellular matrix (Collagen I Collagen III). vitro showed remarkably suppressed activation fibroblasts myofibroblast transition induced transforming growth factor-β (TGF-β). Furthermore, inhibited expression α-SMA, collagen I, III TGF-β/smad2/3 signaling pathway. Immunofluorescence ELISA detection revealed not only alleviated but also reduced inflammation decreased inflammatory factors (TNF-α, IL-1β, IL-6, MCP-1). Mechanistically, significantly polarization LPS-induced macrophages into M1-type inhibiting NF-κB (P65) related pathways. Therefore, postmyocardial function myofibroblasts M1 macrophages.

Язык: Английский

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Targeting Inflammation with Galectin-3 and PIIINP Modulation Among ST-Segment Elevation Acute Coronary Syndrome Patients Underwent Delayed Percutaneous Coronary Intervention

Biomedicines, Год журнала: 2025, Номер 13(2), С. 259 - 259

Опубликована: Янв. 21, 2025

Background/Objectives: ST-segment elevation acute coronary syndrome (STE-ACS) represents a significant global health challenge, with cardiac remodeling and fibrosis critically affecting recovery after percutaneous intervention (PCI). Colchicine, known for its anti-inflammatory effects, may regulate key fibrotic markers such as Procollagen III N-terminal Propeptide (PIIINP) Galectin-3. This study assesses colchicine’s effect on these biomarkers in STE-ACS patients undergoing delayed PCI. Methods: In this multicenter, randomized, double-blind trial, we examined impact Galectin-3 PIIINP 164 early or Patients received colchicine shortly hospital admission. Biomarker changes were evaluated at 24 h five days post-treatment using two-way ANOVA. Results: Clinical trials the PCI group revealed that levels decreased significantly day one (p < 0.01) further 0.0001), indicating Primary has benefits to inhibition of beyond add-on treatment. But, group, increased 0.01), but decrease observed by was not statistically significant. It is related treatment exceed implantation preventing remodeling. showed reduction 0.0001). Conclusions: Colchicine demonstrates novel efficacy PCI, increase sharp PIIINP, ability control fibrosis. positions breakthrough therapy improving outcomes intervention.

Язык: Английский

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m6A control programmed cell death in cardiac fibrosis

Life Sciences, Год журнала: 2024, Номер 353, С. 122922 - 122922

Опубликована: Июль 18, 2024

Язык: Английский

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Targeted Mitochondrial Function for Cardiac Fibrosis: an Epigenetic Perspective

Free Radical Biology and Medicine, Год журнала: 2025, Номер 228, С. 163 - 172

Опубликована: Янв. 2, 2025

Язык: Английский

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Innovative Approaches to Boost Mesenchymal Stem Cells Efficacy in Myocardial Infarction Therapy

Materials Today Bio, Год журнала: 2025, Номер 31, С. 101476 - 101476

Опубликована: Янв. 9, 2025

Stem cell-based therapy has emerged as a promising approach for heart repair, potentially regenerating damaged tissue and improving outcomes patients with disease. However, the efficacy of stem therapies remains limited by several challenges, including poor cell survival, low retention rates, integration, functional outcomes. This article reviews current enhancement strategies to optimize mesenchymal cardiac repair. Key approaches include optimizing delivery methods, enhancing engraftment, promoting functions through genetic molecular modifications, paracrine effects cells, leveraging biomaterials engineering techniques. By focusing on these techniques, paper highlights innovative that can transform into more viable effective treatment option The ongoing research technological advancements continue push boundaries, hoping make mainstream

Язык: Английский

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Nanomaterials: Promising Tools for the Diagnosis and Treatment of Myocardial Infarction

International Journal of Nanomedicine, Год журнала: 2025, Номер Volume 20, С. 1747 - 1768

Опубликована: Фев. 1, 2025

Abstract: Myocardial infarction (MI) is the leading cause of mortality from cardiovascular diseases. Rapid diagnosis and effective treatment are critical for improving patient prognosis. Although current diagnostic therapeutic approaches have made significant progress, they still face challenges such as ischemia-reperfusion injury, microcirculatory disorders, adverse cardiac remodeling, inflammatory responses. These issues highlight urgent need innovative solutions. Nanomaterials, with their diverse types, excellent physicochemical properties, biocompatibility, targeting capabilities, offer promising potential in addressing these challenges. Advances nanotechnology increasingly drawn attention to application nanomaterials both diagnosing treating myocardial infarction. We summarize pathophysiological mechanisms staging systematically review applications MI diagnosis, including detection biomarkers imaging techniques, well treatment, encompassing anti-inflammatory effects, antioxidant stress, inhibition fibrosis, promotion angiogenesis, conduction repair. analyze existing provide insights into future research directions Specifically, we discuss rigorous safety assessments, long-term efficacy studies, development robust strategies translating laboratory findings clinical practice. In conclusion, holds promise a new strategy Its enhance outcomes revolutionize care makes it an exciting area practical real-world settings. Keywords: infarction, nanomaterials, nanoparticles,

Язык: Английский

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Glucose-dependent insulinotropic polypeptide/glucagon-like peptide 1 receptor agonist tirzepatide promotes branched chain amino acid catabolism to prevent myocardial infarction in non-diabetic mice

Cardiovascular Research, Год журнала: 2025, Номер unknown

Опубликована: Янв. 30, 2025

A novel dual glucose-dependent insulinotropic polypeptide and glucagon-like peptide 1 receptor agonist, tirzepatide (LY3298176, TZP), has been developed to treat Type 2 diabetes mellitus (T2DM). In ischaemic heart diseases, TZP is involved in cardiac metabolic processes. However, its efficacy safety treating failure (HF) following myocardial infarction (MI) remain uncertain. Herein, 12 week C57BL/6J mice were subjected MI surgery, followed by administration of TZP. The effects on function metabolism thoroughly assessed physiological, histological, cellular analyses. Downstream effectors screened through untargeted metabolomics analysis molecular docking. Construct a lower branched chain amino acid (BCAA) diet model determine whether TZP's cardioprotective effect associated with reducing BCAA levels. Our results demonstrated that reduced mortality MI, decreased the infarct area, attenuated cardiomyocyte necrosis. Pathological evaluation tissues increased fibrosis repair inflammatory infiltration. Mechanistically, uncovered positive correlation between catabolism pathway. docking verified could bind branched-chain keto dehydrogenase E1 subunit α (BCKDHA). BCKDHA phosphorylation at S293, enhanced catabolism, inhibited activation activating rapamycin (mTOR) signalling Furthermore, fed low-BCAA post-MI necrosis, repair, These further when used synergistically Taken together, our findings provide new perspectives unrecognized role protection. BCAA/mTOR pathway mice. Consequently, this study may present therapeutic options for patients HF.

Язык: Английский

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Myocardial Characterization on CT: Late Iodine Enhancement and Extracellular Volume

Echocardiography, Год журнала: 2025, Номер 42(2)

Опубликована: Фев. 1, 2025

ABSTRACT Myocardial tissue characterization is fundamental in diagnosing, treating, and managing various cardiac diseases. In recent years, computed tomography (CCT) emerged as a valuable alternative to magnetic resonance (CMR) for myocardial characterization, with the possibility detect scar quantify extracellular volume fraction single CT study advantage of combined coronary arteries evaluation, shorter scanning time, less susceptibility device artifacts compared CMR. However, CCT typically affected by lower contrast‐to‐noise ratio potentially increased radiation exposure. Therefore, deep understanding available technology strategies acquisition optimization importance improve image quality accuracy, while minimizing This review summarizes principles on CCT, protocols according different technologies including dual‐energy innovative photon‐counting detector CT, setting clinical utility.

Язык: Английский

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