Marein Ameliorates Myocardial Fibrosis by Inhibiting HIF-1α and TGF-β1/Smad2/3 Signaling Pathway in Isoproterenol-stimulated Mice and TGF-β1-stimulated Cardiac Fibroblasts

Current Pharmaceutical Design, Год журнала: 2023, Номер 30(1), С. 71 - 80

Опубликована: Дек. 28, 2023

Myocardial fibrosis significantly contributes to the pathogenesis and progression of heart failure.

Язык: Английский

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Quantitating myocardial fibrosis using extracellular extravascular volume determined from computed tomography myocardial perfusion imaging

BMC Medical Imaging, Год журнала: 2024, Номер 24(1)

Опубликована: Фев. 12, 2024

Abstract Purpose Both of extracellular extravascular volume (EEV) and fraction (ECV) were proposed to quantify enlargement myocardial interstitial space due myocardium loss or fibrosis. The study aimed investigate the feasibility using EEV derived from computed tomography (CT) perfusion imaging (VPCT) quantification with single-energy subtraction CT (ECV − SECT ) for quantifying Methods In this study, 17 patients suspected known coronary artery disease underwent examination a dual-source scanner. VPCT was dynamic whole-heart imaging, ECV _SECT calculated late-enhanced images 5 min after bolus contrast injection by subtracting noncontrast baseline. late gadolinium enhancement (LGE) on cardiac magnetic resonance (CMR) used as reference. Results total, 11 73 segments exhibited positivity LGE CMR imaging. These classified into three groups according segments: fibrotic (group I, n = 73), nonfibrotic in LGE-positive II, 103), LGE-negative III, 80). , blood flow (MBF), (MBV) significantly differed among these (all P < 0.05). higher MBF, MBV lower than ones 0.01). independently affected There no significant correlation between . capability diagnose fibrosis equivalent that (area under curve: 0.798 vs. 0.806, 0.844). > 41.2% 10.3% indicated Conclusions is actually first-pass distribution can feasibly be Furthermore, diagnostic efficacy comparable

Язык: Английский

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Abatacept: A Promising Repurposed Solution for Myocardial Infarction-Induced Inflammation in Rat Models

Oxidative Medicine and Cellular Longevity, Год журнала: 2024, Номер 2024, С. 1 - 22

Опубликована: Март 13, 2024

Myocardial infarction (MI) is irreversible damage to the myocardial tissue caused by prolonged ischemia/hypoxia, subsequently leading loss of contractile function and damage. However, after a perilous period, ischemia-reperfusion (IR) itself causes generation oxygen free radicals, disturbance in cation homeostasis, depletion cellular energy stores, activation innate adaptive immune responses. The present study employed Abatacept (ABT), which an anti-inflammatory drug, originally used as antirheumatic response agent. To investigate cardioprotective potential ABT, primarily, dose was optimized chemically induced model necrosis. Thereafter, ABT 5 mg/kg s.c. OD investigated for its surgical IR injury, where animals (n = 30) were randomized into five groups: Sham, IR-C, Telmi10 + (Telmisartan, 10 oral OD), ABT5 IR, perse. telmisartan administered 21 days. On 21st day, subjected LAD coronary artery occlusion 60 min, followed reperfusion 45 min. Further, assessed through hemodynamic parameters, oxidant–antioxidant biochemical enzymatic cardiac inflammatory markers, histopathological analysis, TUNEL assay, immunohistochemical evaluation, immunoblotting explore signaling pathways. statistics performed one-way analysis variance, Tukey comparison post hoc tests. Noteworthy, days pretreatment amended ventricular functions rat models MI. accompanied inhibiting MAP kinase modulating Nrf-2/HO-1 proteins downstream cascade. Overall, work bolsters previously known role MI contributes mechanistic insight application clinically approved drugs averting response.

Язык: Английский

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Neferine Pretreatment Attenuates Isoproterenol-Induced Cardiac Injury Through Modulation of Oxidative Stress, Inflammation, and Apoptosis in Rats

Applied Biochemistry and Biotechnology, Год журнала: 2024, Номер 196(10), С. 7404 - 7428

Опубликована: Март 25, 2024

Язык: Английский

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Experimental models of myocardial ischemia: classical approaches and innovations (review)

Siberian Journal of Clinical and Experimental Medicine, Год журнала: 2024, Номер 39(1), С. 18 - 27

Опубликована: Апрель 4, 2024

Myocardial ischemia is the basis for many acute and chronic conditions with great social significance. Therefore, experimental models that describe development in humans are necessary a better understanding of pathophysiology these medical surgical methods treatment. Aim: To compare current approaches to modeling myocardial considering pathogenetic features simulated processes. The manuscript describes main ischemia: vitro cellular models, ex vivo isolated heart animal principal components ‘ heart-on-chip’ model possibilities silico modeling. criteria choosing specific by pathophysiological approach, advantages limitations considered.

Язык: Английский

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