Journal of Food Biochemistry, Год журнала: 2024, Номер 2024(1)
Опубликована: Янв. 1, 2024
Natural compounds and their derivatives have been identified as valuable sources of therapeutic ingredients for cancer treatment. The naturally occurring phytochemical palmatine (isoquinoline alkaloid) is extracted from plant parts (rhizomes, roots, stems, stem barks, others) has protective effects including antioxidant, anti‐inflammatory, anticancer. This study aims to summarize the anticancer potential its in treatment numerous types with molecular mechanisms. We also include pharmacokinetic features, botanical origin, toxicological characteristics derivatives. For this, data collected plausible different electronic databases, PubMed, Google Scholar, PubChem, Science Direct, Web Science, Scopus, Springer Link, Wiley Online. findings demonstrate that a effect against variety cancers, breast, colorectal, gastric, ovarian, prostate, pancreatic, skin, hepatocellular cancer, mammary gland tumors. They provoke properties various cell lines via modifying mechanisms like induction oxidative stress, cytotoxicity, apoptosis, inhibition invasion migration, arresting cycle at S phase, antiproliferative, antiangiogenic effects. It suggested may be good option development novel drugs therapy future.
Язык: Английский
Процитировано
1
Agriculture, Год журнала: 2024, Номер 14(9), С. 1478 - 1478
Опубликована: Авг. 30, 2024
Alternariol (AOH) and alternariol monomethyl ether (AME) are secondary metabolites produced by fungi belonging to the genus Alternaria, which generally contaminate fruits but also cereal crops vegetables. The objective of this study was investigate if co-exposure swine epithelial intestinal cell line (IPEC-1) a mixture mycotoxins would cause an increase in toxicity as compared with exposure single toxin. effects individual toxins well those their combination (1:1 ratio), range 1–250 μM, were assessed vitro for viability proliferating IPEC-1 cells then on parameters related oxidative stress. Our results indicate that both AOH AME significantly decreased viability, cytotoxicity induced + higher than toxins. main interaction type ranged from slight synergy AOH-AME affecting 25% (CI = 0.88), evolved into synergistic effect level IL50 0.41) strong at IL90 0.10). In addition, we investigated two low concentrations (2.5 μM 5 μM) administered individually or stress cells. Both can induce reactive oxygen species—ROS (+) cells%—and damage porcine At least additive observed when exposed AOH-AME, consisting percentage ROS oxidation lipids, proteins, DNA toxin effect. A breakdown antioxidant defense after toxins, decrease activity enzymes superoxide dismutase (SOD) catalase (CAT), no synergic resulted conclusion, our data interfere proliferation Moreover, had dose-dependent viability. Also, stronger However, signaling pathways responsible AOH, AME, combinations need further investigations order provide important risk assessments case contamination feed Alternaria
Язык: Английский
Процитировано
0
Beilstein Journal of Organic Chemistry, Год журнала: 2024, Номер 20, С. 2171 - 2207
Опубликована: Авг. 30, 2024
In this overview, naturally occurring resorcylic lactones biosynthetically derived from alternariol and almost exclusively produced by fungi, are discussed with view on their isolation, structure, biological activities, biosynthesis, total syntheses. This class of compounds consists until now 127 compounds, very divers structural motifs. Although only a handful these toxins (i.e., its 9-
Язык: Английский
Процитировано
0
Advances in Basic and Applied Sciences, Год журнала: 2023, Номер 1(1), С. 21 - 32
Опубликована: Июнь 1, 2023
Implementing green chemistry concepts in all areas of science for eco-friendly and sustainable scientific research is necessary.A promising area which principles may have a substantial impact on the quality efficiency natural products extraction mycotoxins.These compounds are poisonous to humans frequently found food feed.In this literature review, we present traditional methods mycotoxins during product analysis using toxic organic solvents updated technical information about such as deep-eutectic solvents, supercritical CO2, pressurized hot water.Within various types has been discussed, with an emphasis factors that influence their extraction, molar ratio extracting solvent, temperature, co-solvents, duration, recovery percentage.
Язык: Английский
Процитировано
1
Journal of Synthetic Organic Chemistry Japan, Год журнала: 2023, Номер 81(11), С. 1073 - 1080
Опубликована: Ноя. 1, 2023
The ubiquitin-proteasome system (UPS) regulates cellular protein degradation to maintain homeostasis (proteostasis). UPS mainly consists of three steps, ubiquitination, deubiquitination, and degradation. In the ubiquitination process, a series enzymes, ubiquitin-activating enzyme (E1), ubiquitin-conjugating (E2), ubiquitin ligase (E3), catalyze formation polyubiquitin chain on target proteins. Prior polyubiquitinated proteins by proteasome, deubiquitination enzymes remove this cleave it into monoubiquitin molecules. plays key role in controlling proteostasis multiple signaling pathways. Dysfunction has been implicated development various diseases, including cancer, neurodegenerative autoimmune diseases. Therefore, inhibitors that disrupt are promising as drug leads. our study, we searched for natural products (NPs) inhibit UPS-dependent proteolysis using dual-reporter HeLa cells expressing UbG76V-green fluorescent (GFP) oxygen-dependent domain HIF1α fused luciferase (ODD-Luc). Here report research NPs these cell-based reporter assays.
Язык: Английский
Процитировано
1
Опубликована: Окт. 10, 2023
Процитировано
0