Background
and
purpose:
Cell
biology
approaches
have
gained
a
successful
integration,
development
application
of
nanotechnology
with
stem
cell
engineering
led
to
the
emergence
new
interdisciplinary
field
known
as
(SCN).
Recent
studies
showed
potential
advancement
developments
for
SCN
applications
in
drug
delivery
systems.
Cancer,
neurodegenerative,
muscle
blood
diseases,
gene
therapies,
tissue
regenerative
medicine
are
important
targets
SCN.
Experimental
approach:
In
this
overview,
we
searched
literature
using
common
online
websites
research
read
open
access,
full-text
available
articles
since
2013.
Key
results:
The
vary
according
type
disease
they
targeted
strategies
proposed,
whether
diagnostic
or
therapeutic.
addition
use
cells,
utilisation
their
membranes,
secretomes,
exosomes
extracellular
vesicles
an
appropriate
strategy
is
also
aspect
research.
Conclusion:
This
brief
overview
over
last
ten
years
aims
provide
insight
into
frontiers
nanotechnology-mediated
Journal of Translational Medicine,
Год журнала:
2025,
Номер
23(1)
Опубликована: Апрель 15, 2025
Cancer
immunotherapy
aims
to
harness
the
body's
own
immune
system
for
effective
and
long-lasting
elimination
of
malignant
neoplastic
tissues.
Owing
advance
in
understanding
cancer
pathology
immunology,
many
novel
strategies
enhancing
immunological
responses
against
various
cancers
have
been
successfully
developed,
some
translated
into
excellent
clinical
outcomes.
As
one
promising
strategy
next
generation
immunotherapies,
activating
multi-cellular
network
(MCN)
within
tumor
microenvironment
(TME)
deploy
multiple
mechanisms
action
(MOAs)
has
attracted
significant
attention.
To
achieve
this
effectively
safely,
delivering
or
pleiotropic
therapeutic
cargoes
targeted
sites
cancerous
tissues,
cells,
intracellular
organelles
is
critical,
which
numerous
nanocarriers
developed
leveraged.
In
review,
we
first
introduce
payloads
categorized
according
their
predicted
functions
physicochemical
structures
forms.
Then,
nanocarriers,
along
with
unique
characteristics,
properties,
advantages,
limitations,
are
introduced
notable
recent
applications
immunotherapy.
Following
discussions
on
targeting
strategies,
a
summary
each
nanocarrier
matching
suitable
provided
comprehensive
background
information
designing
regimens.
Background
and
purpose:
Cell
biology
approaches
have
gained
a
successful
integration,
development
application
of
nanotechnology
with
stem
cell
engineering
led
to
the
emergence
new
interdisciplinary
field
known
as
(SCN).
Recent
studies
showed
potential
advancement
developments
for
SCN
applications
in
drug
delivery
systems.
Cancer,
neurodegenerative,
muscle
blood
diseases,
gene
therapies,
tissue
regenerative
medicine
are
important
targets
SCN.
Experimental
approach:
In
this
overview,
we
searched
literature
using
common
online
websites
research
read
open
access,
full-text
available
articles
since
2013.
Key
results:
The
vary
according
type
disease
they
targeted
strategies
proposed,
whether
diagnostic
or
therapeutic.
addition
use
cells,
utilisation
their
membranes,
secretomes,
exosomes
extracellular
vesicles
an
appropriate
strategy
is
also
aspect
research.
Conclusion:
This
brief
overview
over
last
ten
years
aims
provide
insight
into
frontiers
nanotechnology-mediated
