Journal of Traditional Chinese Medical Sciences,
Год журнала:
2024,
Номер
11(4), С. 423 - 427
Опубликована: Июль 29, 2024
To
determine
the
efficacy
and
safety
of
Yinmei
Kuijie
decoction
combined
with
5-aminosalicylic
acid
(5-ASA)
in
treating
mildly
to
moderately
active
ulcerative
colitis
(UC)
under
real-world
conditions.
This
multicenter,
prospective,
non-randomized,
observational
study
will
be
conducted
settings.
A
total
204
eligible
patients
consecutively
enrolled
study.
Patients
combination
treatment
group
receive
5-ASA,
whereas
those
control
treated
5-ASA
alone.
The
primary
endpoint
a
clinical
response
at
week
12,
defined
as
≥3
point
≥30%
reduction
from
baseline
Mayo
score
≥1
rectal
bleeding
or
=
0
1.
Secondary
endpoints
12
include
health-related
quality
life,
mucosal
healing,
inflammation
indicators.
results
this
may
provide
evidence
UC
principles.
basis
for
further
confirmatory
studies
on
decoction.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Май 9, 2024
Colorectal
cancer
(CRC)
is
a
significant
global
health
burden,
with
high
morbidity
and
mortality
rates.
It
often
diagnosed
at
middle
to
advanced
stage,
affecting
approximately
35%
of
patients
the
time
diagnosis.
Currently,
chemotherapy
has
been
used
improve
patient
prognosis
increase
overall
survival.
However,
can
also
have
cytotoxic
effects
lead
adverse
reactions,
such
as
inhibiting
bone
marrow
hematopoiesis,
causing
digestive
dysfunction,
hand-foot
syndrome,
even
life-threatening
conditions.
In
response
these
effects,
researchers
proposed
using
Traditional
Chinese
Medicine
(TCM)
an
option
treat
cancer.
TCM
research
focuses
on
prescriptions,
herbs,
components,
which
form
essential
components
current
in
medicine.
The
study
implementation
prescriptions
herbs
demonstrate
its
distinctive
holistic
approach
therapy,
characterized
by
applying
multi-component
multi-target
treatment.
TMC
advantages
developing
new
drugs
they
consist
single
ingredients,
require
smaller
medication
dosages,
precise
measure
pharmacodynamic
clear
mechanism
action
compared
herbs.
further
still
needed
determine
whether
fully
substitute
therapeutic
efficacy
prescriptions.
This
paper
presents
comprehensive
analysis
advancements
made
components.
findings
this
serve
theoretical
basis
for
who
are
interested
exploring
potential
treatment
colorectal
World Journal of Gastrointestinal Oncology,
Год журнала:
2025,
Номер
17(3)
Опубликована: Фев. 13, 2025
Colorectal
cancer
(CRC)
is
the
most
prevalent
globally,
and
its
traditional
treatment
modalities
commonly
encompass
radiation
therapy,
chemotherapy,
surgery
administration
of
cytotoxic
drugs.
Currently,
novel
chemotherapy
drugs
that
combine
Chinese
medicine
(TCM)
with
herbal
extracts
exhibit
superior
comprehensive
benefits.
Herein,
we
delved
into
an
article
authored
by
Wang
et
al
,
focusing
specifically
on
pharmacological
effects
"Herba
Patriniae
Coix
seed
(HC)"
their
targeted
mechanisms
in
combating
CRC.
From
perspective
TCM
philosophy,
damp-heat
stagnation
toxicity
are
cardinal
pathogenic
factors
underlying
HC,
renowned
for
abilities
to
antipyretic
enhance
diuresis,
have
demonstrated
promising
efficacy
preliminary
studies
These
findings
offer
potential
insights
favor
fostering
anti-cancer
medications.
Frontiers in Chemistry,
Год журнала:
2025,
Номер
13
Опубликована: Май 8, 2025
Astragali
Radix
(AR)
-
Curcumae
Rhizoma
(vinegar
processed,
CR)
herb
pair
was
recorded
in
'YIXUE
ZHONGZHONG
CANXILU'
to
treat
colitis-associated
colorectal
cancer
(CAC).
Hedysari
(HR)
categorized
under
the
AR
entry
'SHENNONG
BENCAO
JING'.
HR
is
still
an
alternative
paired
with
CR
clinically
northwest
China.
Praeparata
Cum
Melle
(HRPCM)
a
product
that
fries
honey
enhance
therapeutic
effect.
However,
mechanism
of
HRPCM
(HRCR)
CAC
needs
be
further
elucidated.
HRCR-MIAS
were
prepared
using
eversion
intestinal
sac
method.
UHPLC
Q-Exactive-MS
investigated
compositions
HRCR-MIAS.
Then,
HRCR
mice
predicted
based
on
network
pharmacology
analysis
combination
The
pharmacodynamic
effects
for
SW620
colon
cells
invested
vitro.
efficacies
low-,
middle-,
and
high-dose
groups
(HRCR-L,
3.413
g/kg;
HRCR-M,
6.825
HRCR-H,
13.650
g/kg)
explored.
Enzyme-linked
immunosorbent
assay
(ELISA)
kits
employed
inflammatory
factors
levels,
like
IL-1β,
IL-6,
IL-10,
TNF-α
serum.
expressions
permeability
proteins,
such
as
Claudin-1,
Occludin,
ZO-1,
detected
via
immunohistochemical
(IHC)
analysis.
Finally,
signalling
verified
by
Western
blot
(WB).
855
common
components
identified
HRCR-MIAS,
25
specific
pointed
out.
Based
analysis,
response
cross-linked
MAPK
NF-kB
main
reasons
CAC.
inhibited
proliferation,
induced
apoptosis,
regulated
cell
cycle
progression,
restrained
cells'
ability
migrate
invade
outcomes
WB
experiment
exhibited
expression
key
proteins
MEKK1,
RAS,
ERK,
IKB
MAPK/NF-kB
pathway
cells.
study
vivo
found
different
doses
recovered
loss
body
weight,
shortened
length,
increased
tumour
counts,
abnormal
changes
spleen
thymus
indices,
colonic
lesions,
unbalanced
levels
serum,
down-regulated
ZO-1.
Experimental
validation
confirmed
including
MEKK1
IKB,
NF-kB,
mice.
not
only
suppresses
process
inflammation
improves
but
also
relieves
inhibiting
activated
cascade
alleviate
Journal of Functional Foods,
Год журнала:
2023,
Номер
108, С. 105748 - 105748
Опубликована: Авг. 31, 2023
Hedysari
Radix
Praeparata
Cum
Melle
(HR)
has
a
potential
to
decrease
the
risk
of
chronic
colorectal
inflammation
developing
cancer.
Our
study
found
that
HR
attenuated
pathological
state,
improved
survival
rate,
diminished
K-Ras,
IL-1β,
IL-6
and
TNF-α
levels,
increased
levels
intestinal
barrier
function
proteins
including
claudin-1,
E-cadherin
mucin-2
in
colitis-associated
cancer
(CAC)
mice.
Moreover,
maintains
flora
homeostasis
fecal
metabolic
profiling
through
balancing
abundances
bacteroides
prevotellaceae_UCG-001,
staphylococcus,
turicibacter,
rikenella
further
regulates
galactose
metabolism.
The
spearman
correlation
analysis
showed
proteins,
gut
microbiota
differential
metabolism
were
significantly
correlated
with
each
other.
This
confirmed
mechanism
alleviates
CAC
by
diminishing
symptoms
inflammation,
thereby
improving
preserving
profiling.
World Journal of Gastrointestinal Oncology,
Год журнала:
2024,
Номер
16(8), С. 3539 - 3558
Опубликована: Авг. 7, 2024
BACKGROUND
Herba
Patriniae
and
Coix
seed
(HC)
constitute
a
widely
utilized
drug
combination
in
the
clinical
management
of
colorectal
cancer
(CRC)
that
is
known
for
its
diuretic,
anti-inflammatory,
swelling-reducing
properties.
Although
efficacy
has
been
demonstrated
setting,
active
compounds
their
mechanisms
action
CRC
treatment
remain
to
be
fully
elucidated.
AIM
To
identify
active,
CRC-targeting
components
HC
elucidate
involved.
METHODS
Active
were
identified
screened
using
databases.
Targets
each
component
predicted.
CRC-related
targets
obtained
from
human
gene
Interaction
between
identified.
A
“drug-ingredient-target”
network
was
created
core
Gene
Ontology
(GO)
Kyoto
Encyclopedia
Genes
Genomes
(KEGG)
analyses
conducted
key
pathways
Molecular
docking
executed.
In
vitro
experiments
validated
monomers.
RESULTS
Nineteen
identified,
with
acacetin
as
primary
compound.
The
predictive
analysis
454
HC.
Intersection
mapping
2685
yielded
171
intervention
targets,
including
30
targets.
GO
KEGG
indicated
may
influence
phosphoinositide
3-kinase
(PI3K)/Akt
signaling
pathway.
showed
exhibited
an
optimal
interaction
AKT1
,
identifying
PI3K
AKT
P53
genes
likely
targeted
by
during
treatment.
Acacetin
inhibited
HT-29
cell
proliferation
migration,
well
promoted
apoptosis,
.
Western
blotting
revealed
increased
p53
cleaved
caspase-3
expression
decreased
levels
p-PI3K
p-Akt
survivin,
which
contributed
apoptosis.
CONCLUSION
Acacetin,
principal
compound
pair,
migration
cells
apoptosis
through
PI3K/Akt/p53
