CLINICAL AND EXPERIMENTAL MORPHOLOGY,
Год журнала:
2023,
Номер
12(4), С. 5 - 13
Опубликована: Янв. 1, 2023
Dyslipidemia
is
a
conventional
risk
factor
for
atherosclerosis
and
observed
in
most
rheumatic
diseases,
which
leads
to
high
cardiovascular
patients
with
autoimmune
pathology.
The
review
considers
the
main
aspects
of
cholesterol
metabolism
associated
dysfunction
monocytes
macrophages
diseases.
study
pathogenetic
mechanisms
chronic
inflammatory
diseases
great
fundamental
clinical
importance,
since
it
allows
development
new
diagnostic
algorithms
therapeutic
approaches
reduce
risks
these
patients.
Moreover,
can
be
used
creating
alternative
strategies
modify
functions
immune
system.
Keywords:
metabolism,
dyslipidemia,
macrophages,
inflammation,
Science,
Год журнала:
2023,
Номер
381(6663), С. 1189 - 1196
Опубликована: Сен. 14, 2023
Eosinophils
are
granulocytes
that
play
an
essential
role
in
type
2
immunity
and
regulate
multiple
homeostatic
processes
the
small
intestine
(SI).
However,
signals
eosinophil
activity
SI
at
steady
state
remain
poorly
understood.
Through
transcriptome
profiling
of
eosinophils
from
various
mouse
tissues,
we
found
a
subset
expressed
neuromedin
U
(NMU)
receptor
1
(NMUR1).
Fate-mapping
analyses
showed
NMUR1
expression
was
programmed
by
local
microenvironment
further
enhanced
inflammation.
Genetic
perturbation
eosinophil-organoid
coculture
experiments
revealed
NMU-mediated
activation
promotes
goblet
cell
differentiation.
Thus,
NMU
regulates
epithelial
differentiation
barrier
stimulating
NMUR1-expressing
SI,
which
highlights
importance
neuroimmune-epithelial
cross-talk
maintaining
tissue
homeostasis.
Lipids in Health and Disease,
Год журнала:
2024,
Номер
23(1)
Опубликована: Май 27, 2024
Abstract
Background
Recent
interest
in
the
Non-High
Density
to
High
Lipoprotein
Cholesterol
ratio
(NHHR)
has
emerged
due
its
potential
role
metabolic
disorders.
However,
connection
between
NHHR
and
development
of
kidney
stones
still
lacks
clarity.
The
primary
goal
this
research
is
explore
how
correlates
with
stone
incidence.
Methods
An
analysis
was
conducted
on
data
collected
by
National
Health
Nutrition
Examination
Survey
(NHANES)
2007
2018,
focusing
adults
over
20
years
diagnosed
those
available
values.
Employing
weighted
logistic
regression
Restricted
Cubic
Spline
(RCS)
models,
levels’
correlation
risk
examined.
Extensive
subgroup
analyses
were
for
enhanced
reliability
findings.
Results
findings
indicate
a
heightened
at
highest
levels
relative
lowest
(reference
group).
A
notable
non-linear
incidence
been
observed,
significant
P
-value
(<
0.001),
consistent
across
various
subgroups.
Conclusion
clear
link
exists
high
increased
American
adult
population.
This
study
highlights
NHHR’s
significance
as
indicator
formation.
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Март 3, 2025
Tumors
often
arise
in
chronically
inflamed,
and
thus
immunologically
highly
active
niches.
While
immune
cells
are
able
to
recognize
remove
transformed
cells,
tumors
eventually
escape
the
control
of
system
by
shaping
their
immediate
microenvironment.
In
this
context,
macrophages
major
importance,
as
they
initially
exert
anti-tumor
functions
before
adopt
a
tumor-associated
phenotype
that
instead
inhibits
responses
even
allows
for
sustaining
smoldering
inflammatory,
growth
promoting
tumor
microenvironment
(TME).
Type
I
interferons
(IFNs)
well
established
modulators
inflammatory
reactions.
have
been
shown
directly
inhibit
growth,
there
is
accumulating
evidence
also
play
an
important
role
altering
cell
within
TME.
present
review,
we
focus
on
impact
type
IFNs
responses,
driven
monocytes
macrophages.
Specifically,
will
provide
overview
tumor-intrinsic
factors,
which
impinge
IFN-stimulated
gene
(ISG)
expression,
like
presence
nucleic
acids,
metabolites,
or
hypoxia.
We
further
summarize
current
understanding
consequences
altered
IFN
macrophage
phenotypes,
i.e.,
differentiation,
polarization,
functions.
For
latter,
macrophage-mediated
killing
phagocytosis,
how
affect
environment
secreting
cytokines
interacting
with
cells.
Finally,
discuss
might
should
be
considered
future
therapies.
Lipids in Health and Disease,
Год журнала:
2024,
Номер
23(1)
Опубликована: Сен. 3, 2024
The
value
of
the
non-high-density
lipoprotein
cholesterol
to
high-density
ratio
(NHHR)
assessment
in
context
metabolic
abnormalities
is
growing
importance.
Nevertheless,
relationship
between
NHHR
and
hyperuricemia
(HUA)
unknown.
This
study
seeks
investigate
HUA.
Alzheimer's
disease
(AD)
is
a
multifaceted
neurodegenerative
disorder
characterized
by
cognitive
decline
and
neuronal
loss,
representing
most
challenging
health
issue.
We
present
computational
analysis
of
transcriptomic
data
AD
tissues
vs.
healthy
controls,
focused
on
elucidation
functional
roles
played
long
non-coding
RNAs
(lncRNAs)
throughout
the
progression.
first
assembled
our
own
lncRNA
transcripts
from
raw
RNA-Seq
generated
527
samples
dorsolateral
prefrontal
cortex,
resulting
in
identification
31,574
novel
genes.
Based
co-expression
analyses
between
mRNAs
lncRNAs,
network
constructed.
Maximal
subnetworks
with
dense
connections
are
identified
as
clusters.
Pathway
enrichment
conducted
over
lncRNAs
each
cluster,
which
serve
basis
for
inference
involved
key
steps
an
development
model
that
we
have
previously
build
based
protein-encoding
Detailed
information
presented
about
activities
related
to
stress
response,
reprogrammed
metabolism,
cell-polarity,
development.
Our
also
revealed
discerning
power
distinguishing
stage
controls.
This
study
represents
its
kind.
Gliomas
are
malignant
tumors
originating
from
both
neuroglial
cells
and
neural
stem
cells.
The
involvement
of
contributes
to
the
tumor's
heterogeneity,
affecting
its
metabolic
features,
development,
response
therapy.
This
review
provides
a
brief
introduction
importance
metabolism
in
gliomas
before
systematically
categorizing
them
into
specific
groups
based
on
their
histological
molecular
genetic
markers.
Metabolism
plays
critical
role
glioma
biology,
as
tumor
rely
heavily
altered
pathways
support
rapid
growth,
survival,
progression.
Dysregulated
processes,
involving
carbohydrates,
lipids,
amino
acids
not
only
fuel
development
but
also
contribute
therapy
resistance
metastatic
potential.
By
understanding
these
changes,
key
intervention
points,
such
mutations
genes
like
RTK,
EGFR,
RAS,
IDH
can
be
identified,
paving
way
for
novel
therapeutic
strategies.
emphasizes
connection
between
clinical
challenges,
offering
actionable
insights
future
research
gliomas.
Biomolecules,
Год журнала:
2025,
Номер
15(3), С. 314 - 314
Опубликована: Фев. 20, 2025
The
metabolic
response
to
a
maximal
exercise
test
in
physically
inactive
adults
remains
poorly
understood,
particularly
regarding
the
role
of
adiponectin,
an
adipokine
with
insulin-sensitizing
and
anti-inflammatory
properties.
Adiponectin
circulates
three
isoforms—low
(LMW),
medium
(MMW),
high-molecular-weight
(HMW)—with
differing
bioactivities.
While
is
known
influence
adiponectin
levels,
evidence
conflicting,
few
studies
have
explored
isoform-specific
changes.
This
study
aimed
evaluate
effects
single
session
on
circulating
isoforms
their
associations
kidney
function
markers
young
adults.
In
this
quasi-experimental
study,
twenty-one
participants
(mean
age
24.6
±
2.1
years,
85.7%
women)
completed
progressive
cycle
ergometer
test.
Circulating
levels
LMW
MMW
outcomes
(e.g.,
cholesterol,
triglycerides,
fibroblast
growth
factor
21
(FGF21)),
creatinine,
proteinuria)
were
assessed
before
after
using
biochemical
assays
Western
blotting.
Comparisons
between
pre-
post-exercise
values
made
Wilcoxon
Exercise
increased
lipid
metabolism
(total
HDL)
stress
indicators
(albuminuria,
(p
<
0.05).
showed
no
significant
overall
changes,
but
positively
correlated
changes
total
cholesterol
FGF21,
while
negatively
creatinine
proteinuria
HMW
was
undetectable
by
our
methods.
A
revealed
or
markers,
emphasizing
complex
exercise-induced
responses.
Future
research
should
explore
mechanisms
underlying
these
differential
optimize
interventions
for
health
improvement.
