AIP conference proceedings, Год журнала: 2025, Номер 3270, С. 020110 - 020110
Опубликована: Янв. 1, 2025
Язык: Английский
Frontiers in Nutrition, Год журнала: 2024, Номер 11
Опубликована: Ноя. 22, 2024
Pancreatic cancer (PC) is a highly aggressive malignancy with rising mortality rates globally. Its diagnosis often challenging due to its asymptomatic nature in the early stages. Consequently, most patients receive poor prognosis, low survival within 5 years, as disease typically detected at an advanced stage, complicating effective treatment. Flavonoids, especially those derived from traditional Chinese herbal medicines, have attracted considerable attention for their potent anti-PC properties. This review highlights therapeutic potential of these bioactive compounds, which modulate key biological pathways, making them promising candidates PC intervention. Their mechanisms action include regulation autophagy, apoptosis, cell growth, epithelial-mesenchymal transition, and oxidative stress, well enhancing chemotherapeutic sensitivity, exerting antiangiogenic effects, potentially boosting immunomodulatory responses. The demonstrated benefits natural compounds management spurred extensive academic interest. Beyond role anti-cancer agents, flavonoids may provide both preventive advantages PC, resonating core principles medicine prevention holistic
Язык: Английский
Процитировано
4
Anti-Cancer Drugs, Год журнала: 2025, Номер unknown
Опубликована: Март 12, 2025
Pancreatic cancer is one of the most common malignant tumors digestive system, with majority patients not succumbing to primary tumor but rather metastasis. Epithelial-mesenchymal transition (EMT) abnormally activated in numerous cancers, whereby it promotes cell migration and invasion. Yes-associated protein 1 (YAP1) commonly overexpressed various types plays an oncogenic role. We demonstrated that FV-429, a derivative natural flavonoid wogonin, inhibited invasion metastasis pancreatic cells by modulating EMT-related proteins. FV-429 enhances expression p-LATS1, thereby promoting conversion YAP1 p-YAP1. Meanwhile, suppresses nuclear translocation YAP1, affecting E-cadherin snail1, which, turn, impacts EMT. The Hippo-signaling pathway inhibitor TDI-011536 was used validate these results. In vivo , mouse model lung established using PANC02 antimetastatic effect which confirmed its action through Hippo/YAP1 pathway. addition, high safety low toxicity. conclusion, we inhibits migration, invasion, human pathway, suggesting has potential be novel therapeutic agent for cancer.
Язык: Английский
Процитировано
0
Journal of Biological Chemistry, Год журнала: 2025, Номер unknown, С. 108473 - 108473
Опубликована: Апрель 1, 2025
Tissue inhibitor of metalloproteinase 1 (TIMP1) has been implicated in prostate cancer metastasis. In this study, PC-3M-2B4 cells with TIMP1 knockdown (PC-3M-2B4-shTIMP1) or over-expression (PC-3M-2B4-TIMP1) were generated and an inverse correlation was found between expression cell migration invasion which confirmed vitro vivo. Differential accompanied by variations the ferroptosis-related proteins, glutathione peroxidase 4 (GPX4), transferrin receptor (TFRC), (TF), glutamine cysteine ligase catalytic subunit (GCLC) modifier (GCLM). comparison TIMP1-overexpressing cells, TIMP1-knockdown demonstrated a 12.3% decrease Fe2+ concentration after erastin treatment, 37.8% reduction malondialdehyde (MDA) levels, 113.7% increase GPX4 expression, 78.9% rise GSH/GSSG ratio. Our findings indicate that overexpression promotes ferroptosis modulating critical markers such as TFRC, thereby significantly reducing metastatic potential cells. results highlight TIMP1's role regulating pathways, are crucial for tumor progression, exposes therapeutic target management.
Язык: Английский
Процитировано
0
Acta Pharmacologica Sinica, Год журнала: 2025, Номер unknown
Опубликована: Апрель 9, 2025
Язык: Английский
Процитировано
0
AIP conference proceedings, Год журнала: 2025, Номер 3270, С. 020110 - 020110
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0