Current Drug Therapy,
Год журнала:
2023,
Номер
19(5), С. 561 - 593
Опубликована: Дек. 27, 2023
Abstract:
"Hyaluronic
acid
(HA),
a
non-sulfated
glycosaminoglycan
(GAG),
is
significant
component
of
the
epidermal
extracellular
matrix
(ECM).
It
plays
multiple
roles
in
inflammatory
response,
cell
adhesion,
migration,
proliferation,
differentiation,
angiogenesis,
and
tissue
regeneration.
Due
to
its
inherent
characteristics,
including
non-immunoreactivity,
exceptional
biocompatibility,
biodegradability,
native
biofunctionality,
hydrophilicity,
HA
has
found
applications
production
wound
dressings.
HA's
synergistic
role
enhancing
deeper
penetration
into
chronic
wounds
biofunctional
properties
healing
process
have
been
harnessed.
HA-based
dressings,
often
incorporating
biomolecules
or
drugs
improve
dressing's
biochemical
performance
during
healing,
developed.
In
this
review,
we
explore
current
state
knowledge
regarding
hydrogels
based
on
HA,
focusing
their
delivery
mechanisms.
We
present
latest
developments
research
development
for
treatment
skin
wounds."
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(13), С. 10434 - 10434
Опубликована: Июнь 21, 2023
Wound
healing
is
a
complex
process
involving
cell
proliferation,
migration,
and
extracellular
matrix
(ECM)
remodeling.
Extracellular
vesicles
(EVs)
or
exosomes
derived
from
adipose
tissue-derived
stem
cells
(ASCs)
are
emerging
as
promising
alternatives
to
therapy
for
advanced
wound
healing.
Hyaluronic
acid
(HA),
major
component
of
the
skin
ECM,
widely
utilized
in
dressings
dermal
fillers.
This
study
aimed
investigate
effects
ASC-derived
(ASC-EXOs)
on
human
fibroblasts
(HDFs)
their
potential
combination
with
HA
vivo
filler
models.
In
HDFs,
ASC-EXOs
increased
proliferation
migration.
also
upregulated
expression
genes
involved
while
stimulating
collagen
production
HDFs.
porcine
model,
topical
treatment
led
higher
closure
rates
compared
alone.
Histological
examination
showed
re-epithelialization
type
III
deposition
wounds
treated
ASC-EXOs.
mouse
tissues
injected
exhibited
thicker
tissue
layers,
vascularization,
enhanced
infiltration
myofibroblasts,
levels
fiber
content
These
findings
suggest
that
have
beneficial
gene
related
healing,
they
may
accelerate
promote
regeneration.
Furthermore,
enhance
remodeling,
indicating
its
both
clinical
regenerative
aesthetic
applications
repair
Advanced Drug Delivery Reviews,
Год журнала:
2024,
Номер
207, С. 115203 - 115203
Опубликована: Фев. 9, 2024
MSCs
are
used
for
treatment
of
inflammatory
conditions
or
regenerative
purposes.
complete
cells
and
allogenic
transplantation
is
in
principle
possible,
but
mostly
autologous
use
preferred.
In
recent
years,
it
was
discovered
that
secrete
extracellular
vesicles.
These
active
budded
off
vesicles
carry
a
cargo.
The
cargo
can
be
miRNA,
protein,
lipids
etc.
transported
through
the
body
fuse
with
target
cells.
Thereby,
they
influence
phenotype
modulate
disease.
have,
like
MSCs,
immunomodulatory
capacities.
This
review
will
focus
on
those
features
discuss
their
dual
role.
Besides
immunomodulation,
regeneration
concentrate
bone,
cartilage,
tendon,
vessels
nerves.
Current
clinical
trials
immunomodulation
started
last
five
years
highlighted
as
well.
summary,
have
great
potential
disease
modulating
entity
treatment.
Their
characteristics
need
to
taken
into
account
often
both
important
having
best
effect.
ACS Omega,
Год журнала:
2024,
Номер
9(6), С. 6184 - 6218
Опубликована: Янв. 31, 2024
Extracellular
vesicles
have
emerged
as
promising
tools
in
regenerative
medicine
due
to
their
inherent
ability
facilitate
intercellular
communication
and
modulate
cellular
functions.
These
nanosized
transport
bioactive
molecules,
such
proteins,
lipids,
nucleic
acids,
which
can
affect
the
behavior
of
recipient
cells
promote
tissue
regeneration.
However,
therapeutic
application
these
is
frequently
constrained
by
rapid
clearance
from
body
inability
maintain
a
sustained
presence
at
injury
site.
In
order
overcome
obstacles,
hydrogels
been
used
extracellular
vesicle
delivery
vehicles,
providing
localized
controlled
release
system
that
improves
efficacy.
This
Review
will
examine
role
vesicle-loaded
regeneration,
discussing
potential
applications,
current
challenges,
future
directions.
We
investigate
origins,
composition,
characterization
techniques
vesicles,
focusing
on
recent
advances
exosome
profiling
machine
learning
this
field.
addition,
we
properties
make
them
ideal
carriers.
Recent
studies
utilizing
combination
for
regeneration
be
highlighted,
comprehensive
overview
research
landscape
Materials Today Bio,
Год журнала:
2023,
Номер
23, С. 100840 - 100840
Опубликована: Ноя. 2, 2023
The
repair
of
bone
defects
remains
a
huge
clinical
challenge.
M2
macrophage-derived
exosomes
(M2-Exos)
can
act
as
immunomodulators
to
promote
fracture
healing;
however,
how
retain
the
sustained
release
target
area
Here,
we
report
composite
hydrogel
loaded
with
M2-Exos
aiming
accelerate
defect
healing.
It
was
verified
that
F127/HA-NB
had
dense
network
structure,
tissue
adhesiveness,
and
dual
sensitivity
temperature
light.
(M2-Exos@F127/HA-NB)
exhibited
good
biocompatibility
achieved
for
up
two
weeks.
study
showed
both
M0-Exos
M2-Exos@F127/HA-NB
significantly
promoted
osteogenic
differentiation
rat
marrow
mesenchymal
stem
cells.
mechanism
implied
activates
Wnt/β-catenin
signaling
pathway
BMSCs.
Finally,
evaluated
osteogenetic
effects
in
cranial
model,
results
superior
regeneration-promoting
effects.
This
provides
new
strategy
cell-free
treatment
defects.
Applied Sciences,
Год журнала:
2024,
Номер
14(4), С. 1639 - 1639
Опубликована: Фев. 18, 2024
Breast
cancer
(BC)
caused
685,000
deaths
globally
in
2020,
earning
the
title
of
most
common
type
tumor
among
females.
With
a
multifactorial
genesis,
BC
is
influenced
by
several
factors
such
as
age,
genetic
and
epigenetic
predisposition,
an
individual’s
exposome,
its
classification
based
on
morphological/histological,
invasiveness,
molecular
futures.
Extracellular
vesicles
(EVs)
are
cell-derived
lipid-bilayer-delimited
nanoparticles,
which
distinguishable
size,
markers
expressed
exosomes
(40
to
150
nm),
microvesicles
10,000
apoptotic
bodies
(100–5000
nm).
Produced
physiological
pathological
cellular
contexts,
EVs
shuttles
biological
material
implicated
cell-to-cell
communications,
thus
attracting
significant
interest
diagnostic
drug
delivery
research.
We
report
discuss
latest
evidence
regarding
important
role
BC,
deepening
their
implication
tumorigenesis
metastatic
mechanisms.
On
other
hand,
use
BC-derived
prognostic
biomarkers
therapeutic
approaches
undergoing
investigation.
Hence,
have
become
new
weapons
precision
medicine;
however,
only
with
support
advanced
algorithms
artificial
intelligence
(AI)
can
we
develop
wide
range
information.
Looking
ahead,
it
possible
see
application
AI
prognosis
diagnosis
different
pathologies.
