Exploring the interplay between PARP1 and circRNA biogenesis and function DOI Creative Commons
Héjer Dhahri, Yvonne Fondufe‐Mittendorf

Wiley Interdisciplinary Reviews - RNA, Год журнала: 2023, Номер 15(1)

Опубликована: Ноя. 13, 2023

Abstract PARP1 (poly‐ADP‐ribose polymerase 1) is a multidomain protein with flexible and self‐folding structure that allows it to interact wide range of biomolecules, including nucleic acids target proteins. interacts its molecules either covalently via PARylation or non‐covalently through PAR moieties induced by auto‐PARylation. These diverse interactions allow participate in complex regulatory circuits cellular functions. Although the most studied PARP1‐mediated functions are associated DNA repair stress response, subsequent discoveries have revealed additional biological Based on these findings, now recognized as major modulator gene expression. Several show this multifunctional has been intimately connected several steps mRNA biogenesis, from transcription initiation splicing, polyadenylation, export, translation Nevertheless, our understanding PARP1's involvement biogenesis both coding noncoding RNA, notably circular RNA (circRNA), remains restricted. In review, we outline possible roles circRNA biogenesis. A full examination nuclear processes an emphasis may reveal new avenues control dysregulation implicated pathogenesis diseases such neurodegenerative disorders cancers. This article categorized under: Interactions Proteins Other Molecules > Protein‐RNA Interactions: Functional Implications Regulatory RNAs/RNAi/Riboswitches RNAs Processing Splicing Regulation/Alternative

Язык: Английский

Aminomethylmorpholino Nucleosides as Novel Inhibitors of PARP1 and PARP2: Experimental and Molecular Modeling Analyses of Their Selectivity and Mechanism of Action DOI Open Access
Irina A. Chernyshova, И. А. Васильева, Nina Moor

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(23), С. 12526 - 12526

Опубликована: Ноя. 22, 2024

Poly(ADP-ribose) polymerases 1 and 2 (PARP1 PARP2) play a key role in DNA repair. As major sensors of damage, they are activated to produce poly(ADP-ribose). PARP1/PARP2 inhibitors have emerged as effective drugs for the treatment cancers with BRCA deficiencies. Here, we explored aminomethylmorpholino glycine nucleosides PARP1 PARP2, using different enzymatic assays. The compounds bearing thymine or 5-Br(I)-uracil bases displayed highest inhibition potency, all them being more selective toward PARP1. Interaction NAD

Язык: Английский

Процитировано

0
Exploring the interplay between PARP1 and circRNA biogenesis and function DOI Creative Commons
Héjer Dhahri, Yvonne Fondufe‐Mittendorf

Wiley Interdisciplinary Reviews - RNA, Год журнала: 2023, Номер 15(1)

Опубликована: Ноя. 13, 2023

Abstract PARP1 (poly‐ADP‐ribose polymerase 1) is a multidomain protein with flexible and self‐folding structure that allows it to interact wide range of biomolecules, including nucleic acids target proteins. interacts its molecules either covalently via PARylation or non‐covalently through PAR moieties induced by auto‐PARylation. These diverse interactions allow participate in complex regulatory circuits cellular functions. Although the most studied PARP1‐mediated functions are associated DNA repair stress response, subsequent discoveries have revealed additional biological Based on these findings, now recognized as major modulator gene expression. Several show this multifunctional has been intimately connected several steps mRNA biogenesis, from transcription initiation splicing, polyadenylation, export, translation Nevertheless, our understanding PARP1's involvement biogenesis both coding noncoding RNA, notably circular RNA (circRNA), remains restricted. In review, we outline possible roles circRNA biogenesis. A full examination nuclear processes an emphasis may reveal new avenues control dysregulation implicated pathogenesis diseases such neurodegenerative disorders cancers. This article categorized under: Interactions Proteins Other Molecules > Protein‐RNA Interactions: Functional Implications Regulatory RNAs/RNAi/Riboswitches RNAs Processing Splicing Regulation/Alternative

Язык: Английский

Процитировано

0