Investigating Frailty, Polypharmacy, Malnutrition, Chronic Conditions, and Quality of Life in Older Adults: Large Population-Based Study (Preprint) DOI
Yunmei Liu, Lei Huang,

Fei Hu

и другие.

Опубликована: Июль 6, 2023

BACKGROUND Aging, a significant public health issue, is associated with multiple concurrent chronic diseases and aging-related conditions (geriatric syndromes). OBJECTIVE This study aims to investigate the impact of age on geriatric syndromes intercorrelations between quality life (QoL) in older adults (aged ≥65 years) at population level. METHODS A large representative sample was randomly selected from county China, Feidong, 17 towns 811,867 residents. Multiple conditions, (frailty, polypharmacy, malnutrition), QoL were assessed compared. Associations demographic information using multivariable-adjusted logistic regression. Intercorrelations age, syndromes, investigated both correlation analysis restricted cubic splines–based dose-response analysis. RESULTS Older comprised 43.42% (3668/8447) entire population. The prevalence frailty, premalnutrition or malnutrition, impaired (median 73, IQR 69-78 years; 1871/3668, 51% men) 8.26% (303/3668), 15.59% (572/3668), 3.22% (118/3668), 10.8% (396/3668), respectively. Different sex subgroups mostly had similar (except that frailty occurred more often age). Premalnutrition malnutrition lower frequency obesity higher constipation, polypharmacy diabetes constipation hernia, hypertension, diabetes, physical disability, constipation. Mini Nutritional Assessment–Short Form, Groningen Frailty Indicator, EQ-5D-5L scores, as well number medications used, predicted each other QoL. Impaired polypharmacy. At 1.5-year follow-up, linked baseline, baseline. Causal mediation analyses showed mediated link worse CONCLUSIONS In this population-based adults, ≥1 syndromes. Geriatric intercorrelated with, predictive of, QoL; causal relationships existed QoL, being mediators. findings might be biased by residual confounding factors. It important perform personalized syndrome assessments stratified condition; active prevention intervention for, any help reduce others improve

Язык: Английский

Frailty, polypharmacy, malnutrition, chronic conditions, and quality of life in the elderly: Large population-based study (Preprint) DOI Creative Commons
Yunmei Liu, Lei Huang,

Fei Hu

и другие.

JMIR Public Health and Surveillance, Год журнала: 2024, Номер 10, С. e50617 - e50617

Опубликована: Авг. 15, 2024

Background Aging, a significant public health issue, is associated with multiple concurrent chronic diseases and aging-related conditions (geriatric syndromes). Objective This study aims to investigate the impact of age on geriatric syndromes intercorrelations between quality life (QoL) in older adults (aged ≥65 years) at population level. Methods A large representative sample was randomly selected from county China, Feidong, 17 towns 811,867 residents. Multiple conditions, (frailty, polypharmacy, malnutrition), QoL were assessed compared. Associations demographic information using multivariable-adjusted logistic regression. Intercorrelations age, syndromes, investigated both correlation analysis restricted cubic splines–based dose-response analysis. Results Older comprised 43.42% (3668/8447) entire population. The prevalence frailty, premalnutrition or malnutrition, impaired (median 73, IQR 69-78 years; 1871/3668, 51% men) 8.26% (303/3668), 15.59% (572/3668), 3.22% (118/3668), 10.8% (396/3668), respectively. Different sex subgroups mostly had similar (except that frailty occurred more often age). Premalnutrition malnutrition lower frequency obesity higher constipation, polypharmacy diabetes constipation hernia, hypertension, diabetes, physical disability, constipation. Mini Nutritional Assessment–Short Form, Groningen Frailty Indicator, EQ-5D-5L scores, as well number medications used, predicted each other QoL. Impaired polypharmacy. At 1.5-year follow-up, linked baseline, baseline. Causal mediation analyses showed mediated link worse Conclusions In this population-based adults, ≥1 syndromes. Geriatric intercorrelated with, predictive of, QoL; causal relationships existed QoL, being mediators. findings might be biased by residual confounding factors. It important perform personalized syndrome assessments stratified condition; active prevention intervention for, any help reduce others improve

Язык: Английский

Процитировано

3
Pharmacological treatments and medication-related problems in nursing homes in Catalonia: a multidisciplinary approach DOI Creative Commons
Emilie Anderssen-Nordahl,

Margarita Sánchez-Arcilla Rosanas,

Montserrat Bosch

и другие.

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Март 11, 2024

Background: Aging correlates with increased frailty, multi-morbidity, and chronic diseases. Furthermore, treating the aged often entails polypharmacy to achieve optimal disease management, augmenting medication-related problems (MRPs). Few guidelines tools address problem of MRPs, mainly within institutionalized elderly population. Routine pharmacological review is needed among patients. This may improve a multidisciplinary approach collaboration multiple health professionals. study aimed describe patients, systematically their medication plans, then give recommendations identify MRPs. Methods: A cross-sectional was performed using data obtained from patients living in five nursing homes northern area Barcelona, Spain. The inclusion criteria comprised public coverage provided by Health Department Catalonia. detailed description clinical characteristics, diseases, treatments, recommendations, incomplete data, such as potential drug–drug interactions, therapeutic duplications, contraindications, drugs deemed inappropriate or doubtful efficacy, made. pharmacologist medical doctor specialist who acted coordinator team actively reviewed all prescribed medications make detect Results: total 483 were included. Patients had mean age 86.3 (SD 8.8) years, 72.0% female individuals. All at least three health-related problems, 17.4 5.6). except one, minimum one prescription, 8.22 3.5) per patient. Recommendations made for 82.4% Of these verification adequate use 69.3% withdrawal drug 49.5%. Conclusion: demonstrates high prevalence several Many made, confirming proportion polypharmacy, need standardized interventions. approach, including general practitioners, geriatric assessments, pharmacist, pharmacologist, should this problem.

Язык: Английский

Процитировано

2
The impact of a multidisciplinary team intervention on medication prescription in nursing homes in Catalonia DOI Creative Commons
Emilie Anderssen-Nordahl, Eladio Fernández-Liz, Mònica Sabaté

и другие.

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Сен. 13, 2024

In response to the rising population of nursing home residents with frailty and multimorbidity, optimizing medication safety through drug utilization review addressing medication-related problems (MRPs) is imperative. Clinical decision support systems help reduce errors detect potential MRPs, as well reviews performed by a multidisciplinary team, but these combined assessments are not commonly performed. The objective this study was evaluate impact on plans team intervention in homes, analyzing plan before after assessing whether recommendations given had been implemented.

Язык: Английский

Процитировано

2
Investigating Frailty, Polypharmacy, Malnutrition, Chronic Conditions, and Quality of Life in Older Adults: Large Population-Based Study (Preprint) DOI
Yunmei Liu, Lei Huang,

Fei Hu

и другие.

Опубликована: Июль 6, 2023

BACKGROUND Aging, a significant public health issue, is associated with multiple concurrent chronic diseases and aging-related conditions (geriatric syndromes). OBJECTIVE This study aims to investigate the impact of age on geriatric syndromes intercorrelations between quality life (QoL) in older adults (aged ≥65 years) at population level. METHODS A large representative sample was randomly selected from county China, Feidong, 17 towns 811,867 residents. Multiple conditions, (frailty, polypharmacy, malnutrition), QoL were assessed compared. Associations demographic information using multivariable-adjusted logistic regression. Intercorrelations age, syndromes, investigated both correlation analysis restricted cubic splines–based dose-response analysis. RESULTS Older comprised 43.42% (3668/8447) entire population. The prevalence frailty, premalnutrition or malnutrition, impaired (median 73, IQR 69-78 years; 1871/3668, 51% men) 8.26% (303/3668), 15.59% (572/3668), 3.22% (118/3668), 10.8% (396/3668), respectively. Different sex subgroups mostly had similar (except that frailty occurred more often age). Premalnutrition malnutrition lower frequency obesity higher constipation, polypharmacy diabetes constipation hernia, hypertension, diabetes, physical disability, constipation. Mini Nutritional Assessment–Short Form, Groningen Frailty Indicator, EQ-5D-5L scores, as well number medications used, predicted each other QoL. Impaired polypharmacy. At 1.5-year follow-up, linked baseline, baseline. Causal mediation analyses showed mediated link worse CONCLUSIONS In this population-based adults, ≥1 syndromes. Geriatric intercorrelated with, predictive of, QoL; causal relationships existed QoL, being mediators. findings might be biased by residual confounding factors. It important perform personalized syndrome assessments stratified condition; active prevention intervention for, any help reduce others improve

Язык: Английский

Процитировано

0