International Journal of Biological Macromolecules, Год журнала: 2024, Номер 287, С. 138477 - 138477
Опубликована: Дек. 11, 2024
Язык: Английский
Biomolecules, Год журнала: 2025, Номер 15(1), С. 140 - 140
Опубликована: Янв. 17, 2025
Non-alcoholic fatty liver disease (NAFLD) has become the most common chronic and is closely associated with metabolic diseases such as obesity, type 2 diabetes mellitus (T2DM), syndrome. However, effective treatment strategies for NAFLD are still lacking. In recent years, progress been made in understanding pathogenesis of NAFLD, identifying multiple therapeutic targets providing new directions drug development. This review summarizes advances focusing on mechanisms action natural products, small-synthetic-molecule drugs, combination therapy strategies. aims to provide insights treating NAFLD.
Язык: Английский
Процитировано
2
Biomolecules, Год журнала: 2024, Номер 14(7), С. 836 - 836
Опубликована: Июль 11, 2024
Polyphenols are natural bioactives occurring in medicinal and aromatic plants food beverages of plant origin. Compared with conventional therapies, plant-derived phytochemicals more affordable accessible have no toxic side effects. Thus, pharmaceutical research is increasingly inclined to discover study new innovative molecules for the treatment several chronic human diseases, like type 2 diabetes mellitus (T2DM) osteoporosis. These pathological conditions characterized by a inflammatory state persistent oxidative stress, which interconnected lead development worsening these two health disorders. Oral nano delivery strategies been used improve bioavailability polyphenols allow exert their antioxidant, anti-inflammatory, anti-diabetic, pro-osteogenic biological activities vivo experimental models patients. commonly formulations nutraceuticals, can counteract detrimental effects T2DM osteoporosis pathologies. This review describes that protective against through modulation specific molecular markers pathways. could be as adjuvants, combination synthetic drugs, future develop therapeutic
Язык: Английский
Процитировано
13
International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 140314 - 140314
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
1
Journal of Materials Chemistry B, Год журнала: 2024, Номер 12(40), С. 10163 - 10197
Опубликована: Янв. 1, 2024
Diabetic wounds pose a significant challenge in healthcare due to impaired healing and increased risk of complications. In recent years, various drug delivery systems with stimuli-responsive features have been developed address these issues. These enable precise dosage control tailored release, promoting comprehensive tissue repair regeneration. This review explores targeted therapeutic agents, such as carboxymethyl chitosan-alginate hydrogel formulations, nanofiber mats, core-shell nanostructures, for diabetic wound healing. Additionally, the integration nanotechnology multifunctional biomimetic scaffolds shows promise enhancing outcomes. Future research should focus on optimizing design, materials, printing parameters 3D-bio-printed dressings, well exploring combined strategies involving simultaneous release antibiotics nitric oxide improved
Язык: Английский
Процитировано
6
Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 178, С. 117217 - 117217
Опубликована: Июль 29, 2024
Doxorubicin (DOX), a commonly used chemotherapy drug, is hindered due to its tendency induce cardiotoxicity (DIC). Ferroptosis, novel mode of programmed cell death, has received substantial attention for involvement in DIC. Recently, natural product-derived ferroptosis regulator emerged as potential strategy treating In this review, comprehensive search was conducted across PubMed, Web Science, Google Scholar, and ScienceDirect databases gather relevant articles on the use products DIC relation ferroptosis. The available papers were carefully reviewed summarize therapeutic effects underlying mechanisms modulating treatment. It found that plays an important role pathogenesis, with dysregulated expression ferroptosis-related proteins strongly implicated condition. Natural products, such flavonoids, polyphenols, terpenoids, quinones can act GPX4 activators, Nrf2 agonists, lipid peroxidation inhibitors, thereby enhancing viability, attenuating myocardial fibrosis, improving cardiac function, suppressing both vitro vivo models This review demonstrates strong correlation between DOX-induced key proteins, GPX4, Keap1, Nrf2, AMPK, HMOX1. are likely exert against by activity these proteins.
Язык: Английский
Процитировано
5
Molecular and Cellular Biochemistry, Год журнала: 2025, Номер unknown
Опубликована: Янв. 17, 2025
Язык: Английский
Процитировано
0
Afghanistan Journal of Basic Medical Science, Год журнала: 2025, Номер 2(1), С. 24 - 36
Опубликована: Янв. 17, 2025
Background: The extensive application of antibiotics for bacterial disease treatment has resulted in the emergence antibiotic resistance and biofilm formation, a significant issue that contributes to increased illness death rates. Quorum sensing (QS) is cell-cell communication bacteria involved formation which this pathway triggered by signaling molecules called auto inducers. Inhibition enzymes produce such molecules, instance, acyl-homoserine lactone synthase (AHL) QS would be appreciable enhance effect prevent formation. Taxifolin, subclass flavanonols flavonoids, with its diverse medicinal properties was used study verify inhibition enzyme. Methods: For finding interaction binding affinity between taxifolin AHLs synthase, molecular docking applied, using Autodock 4.2.2. MD simulations were launched find free enzyme enzyme/ligand structure detail, utilizing AMBER99SB force field within GROMACS 2019.6 software. Results: Outcomes from dynamics revealed favorable hydrogen bonds van der Waals interactions synthase. Using as an inhibitor analog target showed effective strategy against multi-drug Conclusion: We utilized computational techniques propose taxifolin, known health benefits, could potentially inhibit AHL
Язык: Английский
Процитировано
0
Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 239 - 272
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Journal of Virology, Год журнала: 2025, Номер unknown
Опубликована: Фев. 10, 2025
ABSTRACT Nucleic acid aptamers are a promising drug modality, whereas the generation of virus-neutralizing has remained difficult due to lack robust system for targeting viral particles interest. Here, we took advantage our latest platform technology Systematic Evolution Ligands by EXponential enrichment (SELEX) with virus-like (VLPs) and targeted chikungunya virus (CHIKV) as model, pathogenic reemerging an unmet need control. The identified aptamer against CHIKV-VLPs, Apt#1, its truncated derivatives showed neutralizing activity nanomolar IC50 values in cell-based assay using pseudoviral particle CHIKV (CHIKVpp). An antiviral-based chemical genetics approach revealed significant competition Apt#1 suramin, reported interactant domain A E2 envelope protein (E2DA), both CHIKVpp surface plasmon resonance (SPR) analyses, predicting E2DA be interface. In addition, interfered attachment CHIKVpp, collectively suggesting property inhibitor via CHIKV. Thus, VLP-targeted proved contribute anti-CHIKV strategies confirmed utility novel viable option development agents IMPORTANCE Our SELEX VLPs generated that bind native conformation incorporated achieve binding effects. Indeed, aptamer-probed target is representative neutralization site on particle, validating VLP-driven procedure. Simultaneously, enhanced antiviral effects combination approved drugs human cells indicated potential therapeutic expected help address needs affinity demonstrated SPR analysis can also lead conjugates antivirals guiding molecules aptasensors diagnostic tools. Overall, VLP-based method provided well versatile applicable other emerging viruses, preparation outbreaks rapid next-generation theranostics.
Язык: Английский
Процитировано
0
Acta Pharmaceutica Sinica B, Год журнала: 2025, Номер unknown
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0