PubMed, Год журнала: 2024, Номер 27(11), С. 1423 - 1429
Опубликована: Янв. 1, 2024
This investigation explored the mechanism by which total flavonoids of
Язык: Английский
PubMed, Год журнала: 2024, Номер 27(11), С. 1423 - 1429
Опубликована: Янв. 1, 2024
This investigation explored the mechanism by which total flavonoids of
Язык: Английский
Cryptography, Год журнала: 2025, Номер 9(1), С. 17 - 17
Опубликована: Март 7, 2025
With the rise in applications of artificial intelligence (AI) across various sectors, security concerns have become paramount. Traditional AI systems often lack robust measures, making them vulnerable to adversarial attacks, data breaches, and privacy violations. Cryptography has emerged as a crucial component enhancing by ensuring confidentiality, authentication, integrity. This paper presents comprehensive bibliometric review understand intersection between cryptography, AI, security. A total 495 journal articles reviews were identified using Scopus primary database. The results indicate sharp increase research interest 2020 January 2025, with significant publications 2023 2024. key application areas include computer science, engineering, materials science. Key cryptographic techniques such homomorphic encryption, secure multiparty computation, quantum cryptography gained prominence Blockchain also an essential technology for securing AI-driven applications, particularly integrity transactions. highlights role safeguarding provides future directions strengthen through advanced solutions.
Язык: Английский
Процитировано
1Neoplasia, Год журнала: 2023, Номер 46, С. 100950 - 100950
Опубликована: Ноя. 16, 2023
This study aimed to investigate the causal relationship between mitochondrial biological function and lung cancer, including its subtypes, via MR. SNPs significantly associated with cancer subtypes were employed as instrumental variables. MR-Egger regression, simple mode, weighted median, utilized determine exposure factor occurrence of subtypes. NADH dehydrogenase (ubiquinone) flavoprotein 2 transmembrane protein 70 found have a adenocarcinoma, acting protective factors. The import inner membrane translocase subunit iron-sulfur 4 small-cell was established risk factor. 1 beta subcomplex 8 exhibited Furthermore, NAD-dependent deacylase sirtuin-5 causally linked squamous cell carcinoma, serving A funnel plot demonstrated symmetrical distribution SNPs. Thew pleiotroy test (P > 0.05) "leave-one-out" validated relative stability results.
Язык: Английский
Процитировано
11Frontiers in Nutrition, Год журнала: 2025, Номер 12
Опубликована: Янв. 22, 2025
Objective The aim of this research was to explore the possible connection between combined Oxidative Balance Score (OBS) and prevalence chronic inflammatory airway diseases (CIAD), including asthma, obstructive pulmonary disease (COPD), bronchitis, along with mortality rate among individuals CIAD. Methods Data were gathered from National Health Nutrition Examination Survey (NHANES) 2013–2018 cycles. calculated using 16 different nutrients 4 lifestyles, which then categorized into four groups. CIAD included self-reported or COPD. Mortality data up December 31, 2019, obtained Death Index. In cross-sectional studies, association OBS total specific examined multiple logistic regressions. Dose–response relationships analyzed through restricted cubic spline regression (RCS). prospective cohort cumulative survival rates determined Kaplan–Meier method compared log-rank tests. Multiple COX regressions conducted evaluate relationship all-cause as well respiratory participants Results A 12,458 adults enrolled in study. demographic characteristics study population revealed a mean age 52.25 ± 15.8 years, 47.73% being male, majority identified Non-Hispanic White (66.87%). We found that 20.26% suffered CIAD, followed by asthma (15.41%), bronchitis (6.10%) COPD (3.80%), respectively. median levels 20.98 standard deviation 0.17. After adjusting for all confounders, we highest quartile significantly associated lower (OR = 0.71, 95% CI 0.64–0.81), 0.62, 0.52–0.73), 0.64, 0.44–0.92), 0.48, 0.31–0.77) lowest quartile. Additionally, linear inverse incidence various disorders. analysis showed had risk both (log-rank test p 0.017) < 0.001). Furthermore, after factors, fourth continued show reduced (HR 0.55–0.93) 0.53, 0.43–0.74) comparison those levels. Conclusion findings higher linked decreased Higher also causes patients. These offer valuable information on role diet lifestyle preventing
Язык: Английский
Процитировано
0The American Journal of Chinese Medicine, Год журнала: 2025, Номер unknown, С. 1 - 30
Опубликована: Янв. 29, 2025
Oxidative stress represents a pivotal mechanism in the pathogenesis of numerous chronic diseases. The Kelch-like ECH-associated protein 1–transcription factor NF-E2 p45-related 2 (KEAP1–NRF2) pathway plays crucial role maintaining redox homeostasis and regulating multitude biological processes such as inflammation, homeostasis, metabolic homeostasis. In this paper, we present findings recent studies on KEAP1–NRF2 pathway, which have revealed that it is aberrantly regulated induces oxidative injury variety diseases neurodegenerative diseases, cardiovascular respiratory digestive cancer. Given evidence, targeting highly promising avenue for developing therapeutic strategies thus development appropriate based NRF2 has emerged significant area research interest. This paper highlights an overview current to modulate KEAP1–NRF2, well advances use natural compounds traditional Chinese medicine, with view providing meaningful guidelines drug discovery KEAP1–NRF2. Additionally, discusses challenges associated harnessing target.
Язык: Английский
Процитировано
0Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0Phytomedicine, Год журнала: 2025, Номер 142, С. 156728 - 156728
Опубликована: Апрель 5, 2025
Язык: Английский
Процитировано
0International Immunopharmacology, Год журнала: 2025, Номер 156, С. 114685 - 114685
Опубликована: Апрель 25, 2025
Язык: Английский
Процитировано
0Heliyon, Год журнала: 2024, Номер 10(10), С. e31559 - e31559
Опубликована: Май 1, 2024
Disturbances in the oral microbiota may be due to several mechanisms and factors, such as smoking. An imbalance bacteria result changes innate immune system development of periodontal disease. This study aimed investigate distribution smokers non-smokers a South African population using subgingival plaque samples. From 128 recruited participants, 57 were identified (serum cotinine: >15 ng/ml). Analysis 16S rRNA gene sequencing demonstrated significant differences between two groups with reduced abundance Actinobacteria smokers. Fusobacterium Campylobacter found higher abundance, while lower Leptotrichia, Actinomyces, Corynebacterium, Lautropia observed. highlighted smokers, indicating an anaerobic gram-negative bacteria. These findings suggest that smoking allows certain microorganisms gain dominance, thereby predisposing individuals disease progression.
Язык: Английский
Процитировано
2Phytomedicine, Год журнала: 2024, Номер 135, С. 156090 - 156090
Опубликована: Окт. 3, 2024
Язык: Английский
Процитировано
2Опубликована: Июнь 26, 2024
Oxidative stress (OS) occurs from excessive reactive oxygen species or a deficiency of antioxidants – primarily endogenous glutathione (GSH). There are many illnesses, acute and post-COVID-19, diabetes, myocardial infarction, to Alzheimer’s disease, that associated with OS. These dissimilar illnesses in order, viral infection, metabolic disorder, an ischemic event, neurodegenerative disorder. OS may be early initiator significant promotor their progressive pathophysiologic processes. Consequently, addressing initial OS-related pathology avoid subsequent severe irreversible complications. Early intervention would modulate multiple factors, including cytokine stimulation, complement dysregulation, immuno-thrombosis, fibrosis, autoimmunity. Past clinical studies addressed have had equivocal results. It due the use ineffective antioxidants, untimely delay use, inefficient delivery system. Experimental used not available for trials. Although GSH can significantly reduce OS, its exogenous is hampered by lack effective By incorporating into cyclodextrin (CD) through nanotechnology, there recent evidence delivered more effectively prevent mitigate injury [1]. Future using GSH/cyclodextrin (GC) complex will needed confirm effectiveness and, hopefully, offer path treat sub-optimally managed currently untreatable illnesses.
Язык: Английский
Процитировано
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