Transforming medicine: artificial intelligence integration in the peripheral nervous system
Frontiers in Neurology,
Год журнала:
2024,
Номер
15
Опубликована: Фев. 14, 2024
In
recent
years,
artificial
intelligence
(AI)
has
undergone
remarkable
advancements,
exerting
a
significant
influence
across
multitude
of
fields.
One
area
that
particularly
garnered
attention
and
witnessed
substantial
progress
is
its
integration
into
the
realm
nervous
system.
This
article
provides
comprehensive
examination
AI’s
applications
within
peripheral
system,
with
specific
focus
on
AI-enhanced
diagnostics
for
system
disorders,
AI-driven
pain
management,
advancements
in
neuroprosthetics,
development
neural
network
models.
By
illuminating
these
facets,
we
unveil
burgeoning
opportunities
revolutionary
medical
interventions
enhancement
human
capabilities,
thus
paving
way
future
which
AI
becomes
an
integral
component
our
system’s
interface.
Язык: Английский
TRPV1 in Dry Eye Disease
Frontiers in Bioscience-Landmark,
Год журнала:
2024,
Номер
29(5)
Опубликована: Май 7, 2024
Dry
eye
disease
(DED)
is
a
prevalent
ophthalmic
ailment
with
intricate
pathogenesis
and
that
occurs
primarily
due
to
various
factors
which
affect
the
ocular
surface.
DED
characterized
by
disruption
of
tear
film
homeostasis,
inflammatory
reaction,
neuroparesthesia.
Transient
receptor
potential
vanilloid
1
(TRPV1)
versatile
can
be
stimulated
heat,
acid,
capsaicin
(CAP),
hyperosmolarity,
numerous
agents.
There
accumulating
evidence
implicates
TRPV1
in
initiation
progression
through
its
detection
hypertonic
conditions
modulation
pathways.
In
this
article,
we
present
comprehensive
review
expression
function
channel
tissues
cells
associated
DED.
addition,
outline
mechanisms
implicate
pathophysiology
The
aim
establish
theoretical
basis
for
as
possible
therapeutic
target
DED,
thereby
encouraging
further
investigations
into
role
Язык: Английский
Predictive Medicine
IGI Global eBooks,
Год журнала:
2025,
Номер
unknown, С. 291 - 314
Опубликована: Апрель 25, 2025
Pain
management
is
a
critical
area
of
research
in
developing
assistive
augmentative
technologies,
brain-computer
interfaces,
exoskeletons,
and
soft
robotics.
Assistive
such
as
gloves
incorporating
flexible
sensors,
offer
promising
avenues
for
pain
relief
improved
functionality.
Brain-computer
interfaces
exoskeletons
are
also
emerging
potential
tools
management,
leveraging
sensor
fusion
musculoskeletal
modelling.
Algorithms
crucial
these
enabling
real-time
through
neuromorphic
computing
predictive
Integrating
computational
pharmacology,
gene
therapy,
regenerative
therapies,
personalized
medicine
approaches,
informed
by
machine
learning,
can
transform
paradigms.
Язык: Английский
Unraveling TRPV1’s Role in Cancer: Expression, Modulation, and Therapeutic Opportunities with Capsaicin
Subramanyam Reddy Chinreddy,
Nicole Tendayi Mashozhera,
Badraldeen Rashrash
и другие.
Molecules,
Год журнала:
2024,
Номер
29(19), С. 4729 - 4729
Опубликована: Окт. 7, 2024
Cancer
is
a
global
health
challenge
with
rising
incidence
and
mortality
rates,
posing
significant
concerns.
The
World
Health
Organization
reports
cancer
as
leading
cause
of
death
worldwide,
contributing
to
nearly
one
in
six
deaths.
pathogenesis
involves
disruptions
cellular
signaling
pathways,
resulting
uncontrolled
cell
growth
metastasis.
Among
emerging
players
biology,
Transient
Receptor
Potential
(TRP)
channels,
notably
TRPV1,
have
garnered
attention
due
their
altered
expression
cells
roles
tumorigenesis
progression.
also
known
the
capsaicin
receptor,
pivotal
pain
mediation,
offering
promise
therapeutic
target.
Activation
TRPV1
triggers
calcium
influx
affects
linked
death.
Additionally,
implicated
cancer-induced
chemo-sensitivity,
upregulation
observed
sensory
neurons
innervating
oral
cancers.
Also,
when
capsaicin,
compound
from
chili
peppers,
interacts
it
elicits
"hot"
sensation
influences
processes
through
influx.
Understanding
TRPV1's
multifaceted
may
lead
novel
strategies
for
managing
cancer-related
symptoms
improving
patient
outcomes.
current
review
elucidates
comprehensive
role
therapy,
particularly
channel,
highlighting
its
effects
various
via
different
pathways
discussing
limitations.
Язык: Английский
Genetic Expression of Transient Receptor Potential Channels in Plaque Psoriasis
Turkish Journal of Dermatology,
Год журнала:
2024,
Номер
18(4), С. 139 - 149
Опубликована: Дек. 30, 2024
Aim:
Psoriasis
is
an
immune-associated
cutaneous
condition
characterized
by
inflammation.The
transient
receptor
potential
canonical
(TRPC),
ankyrin
(TRPA),
melastatin
(TRPM),
vanilloid
(TRPV),
polycystin
(TRPP),
and
mucolipin
(TRPML)
families
are
mammalian
(TRP)
channels,
abnormal
differentiation
or
barrier
dysfunction
may
be
attributed
to
their
expression.This
study
aimed
investigate
gene
expression
in
TRP
channels
psoriatic
cases
associate
the
level
with
disease
severity.Methods:
This
research
was
case-controlled
comprised
60
patients
psoriasis
vulgaris
years
sex-coordinated
well-health
volunteers
as
control
group.The
patient's
entire
history
recorded,
a
general
complete
dermatological
examination
performed.The
severity
evaluated
applying
area
index
score.Venous
blood
samples
were
taken
for
detection
of
TRPC6,
TRPM2,
TRPV1
real-time
polymerase
chain
reaction.
Results:Considering
TRPC6;
mean
lower
than
controls,
statistically
significant
difference
(U
=
661.5
P
<
0.001).Nevertheless,
TRPM2
demonstrated
higher
levels
controls
36
78,
resp.,
0.001
both).Therefore,
can
used
distinguish
from
accuracy
(P
both).
Conclusion:Variations
channel
patterns
involved
etiopathogenesis
useful
promising
agents
treatment.
Язык: Английский