Identification of Cellular Isoschaftoside-Mediated Anti-Senescence Mechanism in RAC2 and LINC00294

Molecules, Год журнала: 2024, Номер 29(17), С. 4182 - 4182

Опубликована: Сен. 4, 2024

As cellular senescence, reactive oxygen species (ROS) accumulate excessively, causing damage. Flavonoids derived from natural products are known for their antioxidant effects and ability to delay senescence. Previous studies have attempted mitigate senescence using flavonoids sources. However, the detailed mechanisms regulatory targets of some exhibiting not been fully elucidated. Therefore, we screened a library properties. Isoschaftoside, glycosidic flavonoid, significantly reduced ROS levels in senescent cells. It was found that mitochondrial function restored, dependence on glycolysis cells treated with isoschaftoside. Additionally, identified isoschaftoside suppresses by reducing expression

Язык: Английский

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Portuguese Grapevine Leaves: A Neglected By-Product with High Potential

Applied Sciences, Год журнала: 2024, Номер 14(21), С. 9803 - 9803

Опубликована: Окт. 27, 2024

In Portugal, grapevine leaves are generally treated as agro-industrial waste, despite being rich in bioactive compounds that offer benefits to human health. This study compiles the most relevant and current data on phytochemical composition properties of grape from both red white varieties cultivated country. These by-products abundant flavonoid non-flavonoid phenolic compounds, such flavonols, derivatives hydroxycinnamic acids, carotenoid pigments, chlorophylls, well fatty which have scientifically proven antioxidant, antimicrobial, anti-inflammatory, antidiabetic, cardio-, neuro- hepatoprotective properties, among others. The combination these beneficial along with low toxicity their makes a by-product great potential for use food, pharmaceutical, cosmetic industries. key challenge is develop sustainable methods reintegrate this into supply chain, alignment sustainability goals 2030 Agenda.

Язык: Английский

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Quantitative instrumental thin-layer chromatography method development of astragalin and its chemical diversity in different populations of Nyctanthes arbor-tristis L.

JPC - Journal of Planar Chromatography - Modern TLC, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 18, 2024

Язык: Английский

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Targeting Nudix Hydrolase 5 with Bioactive Flavonoids: Molecular Dynamics and Docking Studies for Breast Cancer Therapy

Cell Biochemistry and Biophysics, Год журнала: 2024, Номер unknown

Опубликована: Дек. 5, 2024

Язык: Английский

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Differential Accumulation of Bioactive Compounds in Different Populations of Mesona chinensis Benth: An Integrated Transcriptomic and Metabolomic Analysis

Food Bioscience, Год журнала: 2024, Номер unknown, С. 105722 - 105722

Опубликована: Дек. 1, 2024

Язык: Английский

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