Berberine synergises with ferroptosis inducer sensitizing NSCLC to ferroptosis in p53-dependent SLC7A11-GPX4 pathway

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 176, С. 116832 - 116832

Опубликована: Июнь 7, 2024

Berberine (BBR) is a compound derived from Chinese herbal medicine, known for its anticancer properties through multiple signaling pathways. However, whether BBR can inhibit tumor growth by participating in ferroptosis remains unconfirmed. In this study, we demonstrated that berberine synergistically inhibited NSCLC combination with inducers, and down-regulated the mRNA protein expression of SLC7A11, GPX4, NRF2, resulting accompanied significant depletion GSH, aberrant accumulation reactive oxygen species malondialdehyde. lung cancer allograft model, treatment exhibited enhanced effects compared to using either drug alone. Notably, p53 critical determining sensitivity. We found did not elicit synergistic effect cells mutation or exogenous mutant p53. These findings provide insight into mechanism which induces regulatory role process. It may guide development new strategies treating NSCLC, offering great medical potential personal diagnosis treatment.

Язык: Английский

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A Descriptive Review of the Antioxidant Effects and Mechanisms of Action of Berberine and Silymarin

Molecules, Год журнала: 2024, Номер 29(19), С. 4576 - 4576

Опубликована: Сен. 26, 2024

Oxidative stress is a key factor in the development of chronic diseases such as type 2 diabetes, cardiovascular diseases, and liver disorders. Antioxidant therapies that target oxidative damage show significant promise preventing treating these conditions. Berberine, an alkaloid derived from various plants Berberidaceae family, enhances cellular defenses against through several mechanisms. It activates AMP-activated protein kinase (AMPK) pathway, which reduces mitochondrial reactive oxygen species (ROS) production improves energy metabolism. Furthermore, it boosts activity antioxidant enzymes like superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), thus protecting cells damage. These actions make berberine effective managing conditions, neurodegenerative Silymarin, flavonolignan complex Silybum marianum, particularly for protection. nuclear erythroid 2-related (Nrf2) enhancing enzyme expression stabilizing membranes. Additionally, silymarin formation ROS by chelating metal ions, also diminishes inflammation. This makes beneficial conditions non-alcoholic fatty disease (NAFLD) alcohol-related review aims to highlight distinct mechanisms exert their effects.

Язык: Английский

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Modulation of atherosclerosis‐related signaling pathways by Chinese herbal extracts: Recent evidence and perspectives

Phytotherapy Research, Год журнала: 2024, Номер 38(6), С. 2892 - 2930

Опубликована: Апрель 5, 2024

Abstract Atherosclerotic cardiovascular disease remains a preeminent cause of morbidity and mortality globally. The onset atherosclerosis underpins the emergence ischemic diseases, including coronary heart (CHD). Its pathogenesis entails multiple factors such as inflammation, oxidative stress, apoptosis, vascular endothelial damage, foam cell formation, platelet activation. Furthermore, it triggers activation diverse signaling pathways Phosphatidylinositol 3‐kinase/protein kinase B (PI3K/Akt), NF‐E2‐related factor 2/antioxidant response element (Nrf2/ARE), Notch pathway, peroxisome proliferator‐activated receptor (PPAR), nucleotide oligo‐structural domain‐like thermoprotein structural domain‐associated protein 3 (NLRP3), silencing information regulator 2‐associated enzyme 1 (Sirt1), nuclear transcription factor‐κB (NF‐κB), Circular RNA (Circ RNA), MicroRNA (mi Transforming growth factor‐β (TGF‐β), Janus kinase‐signal transducer activator (JAK/STAT). Over recent decades, therapeutic approaches for have been dominated by utilization high‐intensity statins to reduce lipid levels, despite significant adverse effects. Consequently, there is growing interest in development safer more efficacious drugs modalities. Traditional Chinese medicine (TCM) offers vital strategy prevention treatment diseases. Numerous studies detailed mechanisms through which TCM active ingredients modulate molecules influence atherosclerotic process. This article reviews implicated advancements research on extracts treatment, drawing original articles from various databases Google Scholar, Medline, CNKI, Scopus, Pubmed. objective furnish reference clinical management

Язык: Английский

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Argemone mexicana L. (Papaveraceae): chemistry, pharmacology, and toxicology

Phytochemistry Reviews, Год журнала: 2024, Номер 23(4), С. 1167 - 1182

Опубликована: Фев. 3, 2024

Язык: Английский

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The efficacy and safety of berberine in combination with cinnamon supplementation in patients with type 2 diabetes: a randomized clinical trial

European Journal of Nutrition, Год журнала: 2025, Номер 64(2)

Опубликована: Фев. 25, 2025

Язык: Английский

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Utilization of natural products in diverse pathogeneses of diseases associated with single or double DNA strand damage repair

Chinese Medicine, Год журнала: 2025, Номер 20(1)

Опубликована: Апрель 7, 2025

Abstract The appearance of DNA damage often involves the participation related enzymes, which can affect onset and development various diseases. Several natural active compounds have been found to efficiently adjust activity crucial enzymes associated with single or double-strand damage, thus demonstrating their promise in treating This paper provides an in-depth examination summary these modulation mechanisms, leading a thorough review subject. connection between disease is explored through analysis structural characteristics compounds. By reviewing how different scholarly sources describe identical structures using varied terminology, this study also delves into effects on enzyme regulation. offers potentially be used therapeutically influence key activities expression levels, turn process repair (DDR). These shown not only reduce occurrence but boost efficiency processes, presenting new therapeutic opportunities for conditions such as cancer other pathologies. Future research should focus clarifying exact mechanisms maximize clinical utility support creation novel approaches prevention treatment. Graphical abstract

Язык: Английский

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Berberine improves cardiac insufficiency through AMPK/PGC-1α signaling-mediated mitochondrial homeostasis and apoptosis in HFpEF mice

International Immunopharmacology, Год журнала: 2025, Номер 155, С. 114613 - 114613

Опубликована: Апрель 14, 2025

Язык: Английский

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Lipid-based nano-carriers for the delivery of anti-obesity natural compounds: advances in targeted delivery and precision therapeutics

Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)

Опубликована: Май 7, 2025

Obesity is a major global health challenge, contributing to metabolic disorders such as type 2 diabetes, cardiovascular diseases, and hypertension. The increasing prevalence of obesity, driven by sedentary lifestyles, poor dietary habits, genetic predisposition, underscores the urgent need for effective therapeutic strategies. Conventional pharmacological treatments, including appetite suppressants modulators, often fail provide sustainable weight loss due side effects, adherence, limited long-term efficacy. As result, natural bioactive compounds have gained attention their anti-obesity potential. However, clinical application hindered bioavailability, rapid metabolism, inefficient delivery. Lipid-based nano-carriers, liposomes, solid lipid nanoparticles, nanostructured carriers, offer promising solution enhancing solubility, stability, targeted delivery these compounds. These advanced systems improve retention, enable controlled release, enhance action on adipose tissue pathways. Additionally, functionalized stimulus-responsive nanocarriers present innovative approaches precision obesity treatment. Despite advancements, challenges remain in large-scale production, regulatory approval, safety. Overcoming barriers critical ensuring successful translation nano-formulated therapies. This review explores potential lipid-based nano-carriers optimizing efficacy highlights role advancing next-generation management

Язык: Английский

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Traditional Chinese medicine and plant-derived natural products in regulating triglyceride metabolism: Mechanisms and therapeutic potential

Pharmacological Research, Год журнала: 2024, Номер 208, С. 107387 - 107387

Опубликована: Авг. 30, 2024

The incidence of cardiometabolic disease is increasing globally, with a trend toward younger age onset. Among these, atherosclerotic cardiovascular leading cause mortality worldwide. Despite the efficacy traditional lipid-lowering drugs, such as statins, in reducing low-density lipoprotein cholesterol levels, significant residual risk events remains, which closely related to unmet triglyceride (TG) targets. clinical application current TG-lowering Western medicines has certain limitations, necessitating alternative or complementary therapeutic strategies. Traditional Chinese medicine (TCM) and plant-derived natural products, known for their safety owing origins diverse biological activities, offer promising avenues TG regulation potentially fewer side effects. This review systematically summarises mechanisms metabolism subsequently reviews regulatory effects TCM products on metabolism, including inhibition synthesis (via endogenous exogenous pathways), promotion catabolism, fatty acid absorption transport, enhancement lipophagy, modulation gut microbiota, other mechanisms. In conclusion, through comprehensive analysis recent studies, this consolidates multifaceted roles elucidates potential safer, multi-target agents managing hypertriglyceridemia mitigating risk, thereby providing basis new drug development.

Язык: Английский

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Biochemical Investigation of Therapeutic Efficacy of Berberine-Enriched Extract in Streptozotocin-Induced Metabolic Impairment

ACS Omega, Год журнала: 2024, Номер 9(13), С. 15677 - 15688

Опубликована: Март 22, 2024

Metabolic disorders pose significant global health challenges, necessitating innovative therapeutic approaches. This study focused on the multifaceted potential of berberine-enriched extract (BEE) in mitigating metabolic impairment induced by streptozotocin (STZ) a rat model and compared effects BEE with berberine (BBR) metformin (MET) to comprehensively evaluate their impact various biochemical parameters. Our investigation reveals that surpasses BBR MET ameliorating impairment, making it promising candidate for managing disorders. For this, 30 male Wistar rats were divided into five groups (n = 6): control (CN), STZ, STZ + MET, BBR, BEE. The treatment duration was extended over 4 weeks, during which parameters monitored, including fasting blood glucose (FBG), lipid profiles, inflammation, liver kidney function biomarkers, gene expressions metabolizing enzymes. induction evident through an elevated FBG level disrupted profiles. enriched effectively regulated homeostasis, as evidenced restoration levels, superior both MET. Furthermore, demonstrated potent insulin sensitivity, upregulating key genes involved carbohydrate metabolism: GCK, IGF-1, GLUT2. highlights its enhancing utilization responsiveness. Dyslipidemia, common occurrence disorders, managed exhibited efficacy regulating Additionally, anti-inflammatory properties, surpassing lowering levels inflammatory biomarkers (IL-6 TNF-α), thereby resistance systemic inflammation. extract's hepatoprotective nephroprotective effects, indicated further highlight maintaining organ health. Moreover, antioxidant reducing oxidative stress peroxidation tissue homogenates. Histopathological examination pancreas underscored protective BEE, preserving recovering pancreatic β-cells damaged STZ. collective evidence positions offers benefits beyond current treatments. In conclusion, our findings emphasize remarkable provide foundation research mechanisms, long-term safety, clinical translation.

Язык: Английский

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