The Interplay Between Endoplasmic Reticulum Stress and Ferroptosis in Neurological Diseases
Neurochemical Research,
Год журнала:
2025,
Номер
50(2)
Опубликована: Фев. 10, 2025
Язык: Английский
Targets to Search for New Pharmacological Treatment in Idiopathic Parkinson’s Disease According to the Single-Neuron Degeneration Model
Biomolecules,
Год журнала:
2024,
Номер
14(6), С. 673 - 673
Опубликована: Июнь 8, 2024
One
of
the
biggest
problems
in
treatment
idiopathic
Parkinson’s
disease
is
lack
new
drugs
that
slow
its
progression.
L-Dopa
remains
star
drug
this
disease,
although
it
induces
severe
side
effects.
The
failure
clinical
studies
with
depends
on
use
preclinical
models
based
neurotoxins
do
not
represent
what
happens
since
they
induce
rapid
and
expansive
neurodegeneration.
We
have
recently
proposed
a
single-neuron
degeneration
model
for
requires
years
to
accumulate
enough
lost
neurons
onset
motor
symptoms.
This
excessive
formation
aminochrome
during
neuromelanin
synthesis
surpass
neuroprotective
action
enzymes
DT-diaphorase
glutathione
transferase
M2-2,
which
prevent
neurotoxic
effects
aminochrome.
Although
an
effect,
stereotaxic
injection
endogenous
neurotoxin
cannot
be
used
generate
animal.
Therefore,
aim
review
evaluate
strategies
pharmacologically
increasing
expression
DT
diaphorase
GSTM2-2
molecules
vesicular
monoamine
transporter
2,
such
as
pramipexole.
Язык: Английский
Endoplasmic Reticulum Proteins Impact Penetrance in a Pink1-Mutant Drosophila Model
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(3), С. 979 - 979
Опубликована: Янв. 24, 2025
Parkinson’s
disease
(PD)
is
a
neurodegenerative
disorder
with
high
variability
of
age
at
onset,
severity,
and
progression.
This
suggests
that
other
factors,
including
genetic,
environmental,
or
biological
are
play
in
PD.
The
loss
PINK1
causes
recessive
form
PD
typically
fully
penetrant;
however,
it
features
wide
range
further
supporting
the
existence
protective
endogenous
exogenous,
to
role.
Pink1
Drosophila
melanogaster
results
locomotion
deficits,
also
observed
PINK1-related
humans.
In
flies,
deficiency
induces
defects
ability
fly;
nonetheless,
around
ten
percent
mutant
flies
still
capable
flying,
indicating
advantageous
factors
affecting
penetrance
exist
flies.
Here,
we
aimed
identify
mechanisms
underlying
this
reduced
Pink1-deficient
We
performed
genetic
screening
pink1-mutant
RNA
expression
alterations
flying
ability.
most
important
processes
involved
were
transcriptional
translational
activities,
endoplasmic
reticulum
(ER)
regulation,
flagellated
movement
microtubule
organization.
validated
two
ER-related
proteins,
zonda
windbeutel,
positively
affect
Thus,
our
data
suggest
these
influencing
them
may
be
beneficial
for
deficiency.
Язык: Английский
Critical role of microRNAs in cellular quality control during brain aging and neurological disorders: Interplay between autophagy and proteostasis
Life Sciences,
Год журнала:
2025,
Номер
369, С. 123563 - 123563
Опубликована: Март 13, 2025
A
decline
in
cellular
quality
control
mechanisms
is
one
of
the
processes
brain
aging.
Autophagy
and
proteostasis
are
two
regulatory
that
maintain
component
turnover
to
preserve
homeostasis,
optimal
function,
neuronal
health
by
eliminating
damaged
aggregated
proteins
preventing
neurodegenerative
disorders
(NDDs).
Impaired
autophagy
significant
hallmarks
aging
many
age-related
NDDs.
MicroRNAs
noncoding
RNA
molecules
have
recently
been
shown
be
essential
for
regulating
several
biological
processes,
such
as
autophagy,
proteostasis,
differentiation,
development
targeting
mRNA's
3'untranslated
region
(3'UTR).
During
aging,
miRNAs
dysregulate
resulting
abnormal
activity
protein
aggregation,
a
characteristic
This
review
highlights
complex
interactions
orchestration
autophagy.
dysregulation
impairs
autophagic
flux
accelerates
disorders,
neuroinflammation,
neurodegeneration.
Understanding
among
miRNAs,
novel
therapeutics
Язык: Английский
Endoplasmic Reticulum Stress: Implications in Diseases
The Protein Journal,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 13, 2025
Язык: Английский
Parkinson’s Disease: The Neurodegenerative Enigma Under the “Undercurrent” of Endoplasmic Reticulum Stress
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(7), С. 3367 - 3367
Опубликована: Апрель 3, 2025
Parkinson's
disease
(PD),
a
prevalent
neurodegenerative
disorder,
demonstrates
the
critical
involvement
of
endoplasmic
reticulum
stress
(ERS)
in
its
pathogenesis.
This
review
comprehensively
examines
role
and
molecular
mechanisms
ERS
PD.
represents
cellular
response
triggered
by
imbalances
(ER)
homeostasis,
induced
factors
such
as
hypoxia
misfolded
protein
aggregation,
which
activate
unfolded
(UPR)
through
inositol-requiring
enzyme
1
(IRE1),
kinase
R-like
(PERK),
activating
transcription
factor
6
(ATF6)
pathways.
Clinical,
animal
model,
studies
have
consistently
demonstrated
strong
association
between
PD
ERS.
Abnormal
expression
ERS-related
molecules
patients'
brains
cerebrospinal
fluid
(CSF)
correlates
with
progression.
In
models
(e.g.,
Drosophila
mice),
inhibition
alleviates
dopaminergic
neuronal
damage.
Cellular
experiments
reveal
that
PD-mimicking
pathological
conditions
induce
ERS,
while
interactions
mitochondrial
dysfunction
promote
apoptosis.
Mechanistically,
(1)
aggregation
α-synuclein
(α-syn)
mutually
reinforce
neuron
damage;
(2)
leucine-rich
repeat
2
(LRRK2)
gene
mutations
thrombospondin-1
(THBS1)/transforming
growth
beta
(TGF-β1)
interactions;
(3)
Parkin
PTEN-induced
(PINK1)
regulate
Furthermore,
interacts
dysfunction,
oxidative
stress,
neuroinflammation
to
exacerbate
injury.
Emerging
therapeutic
strategies
show
significant
potential,
including
artificial
intelligence
(AI)-assisted
drug
design
targeting
pathways
precision
medicine
approaches
exploring
non-pharmacological
interventions
personalized
electroacupuncture.
Future
research
should
focus
on
elucidating
identifying
novel
targets
develop
more
effective
treatments
for
patients,
ultimately
improving
their
quality
life.
Язык: Английский
Unravelling the role of protein kinase R (PKR) in neurodegenerative disease: a review
Molecular Biology Reports,
Год журнала:
2025,
Номер
52(1)
Опубликована: Апрель 9, 2025
Язык: Английский
Endurance Training Alleviates Metabolic-associated Fatty-liver Disease (MAFLD)-related Testicular Impairments via ER Stress Regulation
Vahid Kazemizadeh,
Nastaran Teimouri,
Azita Faramarzi
и другие.
Research Square (Research Square),
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 18, 2025
Abstract
Metabolic-associated
fatty
liver
disease
(MAFLD),
the
most
prevalent
disorder
globally,
affects
20–40%
of
population
and
presents
significant
health
challenges.
Studies
link
MAFLD
to
male
reproductive
dysfunction,
highlighting
need
for
effective
interventions.
This
study
investigates
impact
on
testicular
function
evaluates
protective
role
endurance
training,
with
a
focus
PERK-EIF2α-ATF4
signaling
pathway.
Forty-four
rats
were
allocated
into
two
dietary
groups
(n
=
22
each):
standard
diet
control
group
(C)
high-fat
supplemented
fructose
water
(FL).
After
17
weeks,
histological
analysis
confirmed
development
in
FL
group,
while
showed
no
pathological
changes.
Each
was
further
subdivided
sedentary
endurance-trained
(T)
subgroups
10
per
subgroup),
resulting
four
experimental
groups:
C,
C
+
T,
FL.
At
end
research,
thyroid
hormones
(T3,
T4,
TSH),
sex
(testosterone,
LH,
FSH)
as
well
PERK,
EIF2α
AFT4
expression
assessed.
Our
result
indicated
that
led
weight
gain,
disrupted
serum
levels
hormones,
impaired
hormone
profiles.
Additionally,
triggered
ER
stress,
evidenced
by
dysregulated
genes
Remarkably,
training
mitigated
these
adverse
effects
normalizing
hormonal
profiles
restoring
stress-related
genes.
These
findings
highlight
critical
stress
MAFLD-induced
dysfunction.
Язык: Английский
Neuroprotective effects of punicalagin and/or micronized zeolite clinoptilolite on manganese‐induced Parkinson's disease in a rat model: Involvement of multiple pathways
CNS Neuroscience & Therapeutics,
Год журнала:
2024,
Номер
30(10)
Опубликована: Окт. 1, 2024
Manganism,
a
central
nervous
system
dysfunction
correlated
with
neurological
deficits
such
as
Parkinsonism,
is
caused
by
the
substantial
collection
of
manganese
chloride
(MnCl
Язык: Английский
Movement of the endoplasmic reticulum is driven by multiple classes of vesicles marked by Rab-GTPases
Allison Langley,
Sarah Abeling-Wang,
Erinn Wagner
и другие.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Май 15, 2024
Peripheral
endoplasmic
reticulum
(ER)
tubules
move
along
microtubules
to
interact
with
various
organelles
through
membrane
contact
sites
(MCS).
Traditionally,
ER
moves
by
either
sliding
stable
via
molecular
motors
or
attaching
the
plus
ends
of
dynamic
tip
attachment
complexes
(TAC).
A
recently
discovered
third
process,
hitchhiking,
involves
motile
vesicles
pulling
microtubules.
Previous
research
showed
that
hitchhikes
on
Rab5-
and
Rab7-marked
endosomes,
but
it
is
uncertain
if
other
Rab-vesicles
can
do
same.
In
U2OS
cells,
we
screened
Rabs
for
their
ability
cotransport
found
post-Golgi
marked
Rab6
(isoforms
a
b).
Rab6-ER
hitchhiking
occurs
independently
ER-endolysosome
contacts
TAC-mediated
movement.
Disrupting
motility
Rab6-vesicles
reduces
overall
Conversely,
relocating
these
cell
periphery
causes
peripheral
accumulation,
indicating
Rab6-vesicle
crucial
subset
movements.
Proximal
TGN46
are
involved
in
while
(Rabs
8/10/11/13/14)
not
essential
Our
further
analysis
finds
Golgi
Rab1
also
capable
driving
Taken
together,
our
findings
suggest
significant
mode
Язык: Английский