Screening and molecular docking verification of feature genes related to phospholipid metabolism in hepatocarcinoma caused by hepatitis B DOI Creative Commons
Jian Zhang,

Fengmei Zhang,

Lei Zhang

и другие.

Lipids in Health and Disease, Год журнала: 2024, Номер 23(1)

Опубликована: Авг. 24, 2024

The progression of tumours is related to abnormal phospholipid metabolism. This study anticipated present a fresh perspective for disease therapy targets hepatocarcinoma caused by hepatitis B virus in the future screening feature genes analysed GSE121248 pinpoint differentially expressed (DEGs). By examining overlap between metabolism-related and DEGs, research focused on involved To find genes, functional enrichment studies were carried out network diagram was proposed. These findings validated via data base Cancer Genome Atlas (TCGA). Further analyses included immune infiltration metabolomics. Finally, relationships abundant metabolites confirmed molecular docking, providing thorough comprehension mechanisms. seven with highest degree connection (PTGS2, IGF1, SPP1, BCHE, NR1I2, NAMPT, FABP1) identified as genes. In TCGA database, also had certain diagnostic efficiency. Immune analysis revealed that regulate various cells. Metabolomics successfully different metabolism pathway patients normal individuals. docking indicated may play essential roles causing targeting this study, first time, it reveals possible involvement linked using bioinformatics analysis. Identifying probable therapeutic could provide clues further treatment disease.

Язык: Английский

Anoikis-related genes in breast cancer patients: reliable biomarker of prognosis DOI Creative Commons

Mingzheng Tang,

Rong Yao, Xiaofeng Li

и другие.

BMC Cancer, Год журнала: 2024, Номер 24(1)

Опубликована: Сен. 19, 2024

Язык: Английский

Процитировано

1
Screening and molecular docking verification of feature genes related to phospholipid metabolism in hepatocarcinoma caused by hepatitis B DOI Creative Commons
Jian Zhang,

Fengmei Zhang,

Lei Zhang

и другие.

Lipids in Health and Disease, Год журнала: 2024, Номер 23(1)

Опубликована: Авг. 24, 2024

The progression of tumours is related to abnormal phospholipid metabolism. This study anticipated present a fresh perspective for disease therapy targets hepatocarcinoma caused by hepatitis B virus in the future screening feature genes analysed GSE121248 pinpoint differentially expressed (DEGs). By examining overlap between metabolism-related and DEGs, research focused on involved To find genes, functional enrichment studies were carried out network diagram was proposed. These findings validated via data base Cancer Genome Atlas (TCGA). Further analyses included immune infiltration metabolomics. Finally, relationships abundant metabolites confirmed molecular docking, providing thorough comprehension mechanisms. seven with highest degree connection (PTGS2, IGF1, SPP1, BCHE, NR1I2, NAMPT, FABP1) identified as genes. In TCGA database, also had certain diagnostic efficiency. Immune analysis revealed that regulate various cells. Metabolomics successfully different metabolism pathway patients normal individuals. docking indicated may play essential roles causing targeting this study, first time, it reveals possible involvement linked using bioinformatics analysis. Identifying probable therapeutic could provide clues further treatment disease.

Язык: Английский

Процитировано

0