Broadening horizons: research on ferroptosis in lung cancer and its potential therapeutic targets
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Янв. 23, 2025
Ferroptosis
is
a
novel
form
of
cell
death
distinct
from
traditional
mechanisms,
characterized
by
the
accumulation
iron
ions
and
production
lipid
peroxides.
It
not
only
affects
survival
tumor
cells
but
also
closely
linked
to
changes
in
microenvironment.
Lung
cancer
one
leading
malignancies
worldwide
terms
incidence
mortality,
its
complex
biological
mechanisms
resistance
make
treatment
challenging.
Recent
studies
have
shown
that
ferroptosis
plays
key
role
onset
progression
lung
cancer,
with
intricate
regulatory
influencing
development
response
therapy.
As
research
into
deepens,
related
molecular
pathways,
such
as
glutamate
metabolism,
antioxidant
defense,
been
gradually
revealed.
However,
clinical
practice,
ferroptosis-based
therapeutic
strategies
for
are
still
their
early
stages.
Challenges
remain,
including
incomplete
understanding
specific
ferroptosis,
insufficient
on
factors,
limited
insight
interactions
within
Therefore,
effective
modulation
enhance
remains
an
urgent
issue.
This
review
summarizes
analyzes
factors
interaction
microenvironment,
further
explores
potential
targeting
ferroptosis.
By
synthesizing
latest
research,
this
paper
aims
provide
new
perspectives
directions
treatment,
goal
advancing
applications.
Язык: Английский
Self-amplifying ROS-responsive SN38 prodrug nanoparticles for combined chemotherapy and ferroptosis in cancer treatment
Carbon,
Год журнала:
2025,
Номер
235, С. 120099 - 120099
Опубликована: Фев. 7, 2025
Язык: Английский
Matrine alkaloids modulating DNA damage repair in chemoresistant non-small cell lung cancer cells
BMC Cancer,
Год журнала:
2024,
Номер
24(1)
Опубликована: Окт. 16, 2024
Non-small
cell
lung
cancer
(NSCLC)
presents
a
significant
challenge
in
the
medical
field
due
to
its
high
incidence
and
resistance
chemotherapy.
Chemoresistance
NSCLC
diminishes
treatment
efficacy
contributes
poor
patient
outcomes.
Matrine
alkaloids
have
shown
promise
reversing
chemotherapy
by
targeting
DNA
repair
mechanisms.
Язык: Английский
Ferroptosis in the adjuvant treatment of lung cancer-the potential of selected botanical drugs and isolated metabolites
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Авг. 13, 2024
Ferroptosis
represents
a
distinct
form
of
cell
death
that
is
not
associated
with
necrosis,
autophagy,
apoptosis,
or
pyroptosis.
It
characterised
by
intracellular
iron-dependent
lipid
peroxidation.
The
current
literature
indicates
number
botanical
drugs
and
isolated
metabolites
can
modulate
ferroptosis,
thereby
exerting
inhibitory
effects
on
lung
cancer
cells
animal
models.
aim
this
review
to
elucidate
the
mechanisms
through
which
regulate
ferroptosis
in
context
cancer,
providing
potential
insights
into
treatment.
crucial
highlight
these
preclinical
findings
should
be
interpreted
as
evidence
treatments
immediately
translated
clinical
applications.
In
future,
we
will
continue
study
pharmacology,
pharmacokinetics
toxicology
drugs,
well
evaluating
their
efficacy
safety
trials,
new
approaches
development
agents
for
treatment
cancer.
Язык: Английский