Influence of saponin tauroside Sx1 on lifespan and expression of vitamin D receptors in the liver tissue of mice with influenza infection DOI Creative Commons
Tatiana Sataieva, Veronika Yu. Maligina, Tatiana P. Makalish

и другие.

Drug development & registration, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 8, 2024

Introduction. Respiratory infections, including influenza, are often accompanied by hepatitis in humans which pathogenesis is not fully understood. According to the available datan D deficiency presumably a risk factor occurrence of acute respiratory viral infections due its modulation immune response. Recent studies indicate that several plant compounds can interact with vitamin receptors (VDRs) and modulate activity VDRs. The biologically active components saponins have found widespread use clinical practice their wide range biological pharmacological effects mechanisms still largely unclear. Aim. To study effect oral administration saponin tauroside Sx1, obtained from Crimean ivy, on life expectancy activation liver mice during experimental infection varying severity. Materials methods. 11 subgroups were formed male BALB/c mice, used experiment depending infectious dose influenza virus, 5 LD 50 virus or 10 respectively, control. Saponin Sx1 was as corrector. Immunohistochemical carried out automatically BOND-MAX immunohistainer (Leica, Germany). Primary rabbit polyclonal antibodies receptor used. Results discussion. Due at 200 μg/mouse/day increases average animals receiving 4.6 days. Reducing IV also changed onset death 2 days both groups. With different doses 10th day subgroups, expression changes without correction. In subgroup 2V, number total positive cells lower than control group. Moreover, 2Vir subgroup, VDR significantly higher Conclusion. µg/mouse/day has fairly pronounced antiviral A/H1N1 manifested an increase (for days) decrease mortality rate severe infection, compared group, where 100 % observed 14th experiment. introduction 4th all reduces intensively express VDR.

Язык: Английский

The Role of Vitamin D Deficiency in Placental Dysfunction: A Systematic Review DOI Creative Commons

Eleni Gerovasili,

Antigoni Sarantaki, Αnastasia Bothou

и другие.

Metabolism Open, Год журнала: 2025, Номер 25, С. 100350 - 100350

Опубликована: Янв. 31, 2025

Vitamin D plays a critical role in pregnancy, supporting placental function via angiogenesis, immune regulation, and nutrient transport. Deficiency vitamin during gestation is associated with complications such as preeclampsia, intrauterine growth restriction (IUGR), preterm birth. However, the mechanisms linking deficiency to dysfunction remain inadequately understood, highlighting need for systematic evaluation. A review was conducted adherence Preferred Reporting Items Systematic Reviews Meta-Analyses (PRISMA) guidelines, searches PubMed, Scopus, Web of Science studies published within last 20 years. Inclusion criteria targeted human examining association between function, including randomized controlled trials, cohort studies, case-control studies. total 10 were included following rigorous screening quality assessment. Findings from indicate that maternal significantly impairs by reducing vascular integrity, downregulating transporters, promoting inflammation. Mechanistic evidence highlights decreased expression endothelial factor (VEGF) increased inflammatory cytokines D-deficient pregnancies. Supplementation active [1α,25(OH)2D3] mitigated these adverse effects, restoring growth, improving transport, Notably, population-specific differences sex-specific responses sufficiency observed. essential optimal pregnancy outcomes. This underscores standardized supplementation protocols further research into long-term effects D. Addressing gaps can inform interventions reduce improve maternal-fetal health.

Язык: Английский

Процитировано

1
Vitamin D: Beyond Traditional Roles—Insights into Its Biochemical Pathways and Physiological Impacts DOI Open Access
Vlad Mihai Voiculescu, Andreea Nelson Twakor,

Nicole Jerpelea

и другие.

Nutrients, Год журнала: 2025, Номер 17(5), С. 803 - 803

Опубликована: Фев. 26, 2025

Background: It is true that vitamin D did not earn its title as the "sunshine vitamin" for nothing. In recent years, however, there has been a shift in perception surrounding to type of hormone boasts countless bioactivities and health advantages. Historically, known take care skeletal integrity calcium-phosphorus balance body, but new scientific research displays much larger spectrum actions handled by this vitamin. Materials Methods: A systematic literature search was performed using following electronic databases: PubMed, Scopus, Web Science, Embase, Cochrane Library. Results: Many emerging ideas, especially concerning alternative hormonal pathways analogs, are uniformly challenging classic "one hormone-one receptor" hypothesis. To add more context this, receptor (VDR) previously assumed be only means through which biologically active steroid 1,25-dihydroxyvitamin D3 could impact body. Two other molecules apart from form 1,25(OH)2D3 have gained interest these reinvigorated on metabolism. These metabolites can interact with several nuclear receptors (like related orphan alpha-RORα, gamma-RORγ, aryl hydrocarbon receptor-AhR) trigger various biological responses. Conclusions: This paper thus makes case placing at forefront holistic dermatological investigating potential synergies between canonical noncanonical pathways. now plentiful opportunities manipulating understanding full actions, far beyond those minerals.

Язык: Английский

Процитировано

1
Impact of Folate Bio-Enriched Fermented Beverage on Vitamin D Receptor and Folate Transporters Expression in the Colon: Insights from In Vitro and In Vivo Studies DOI
Ana Clara Candelaria Cucick, Jonathan Laiño, Alejandra de Moreno de LeBlanc

и другие.

Food Bioscience, Год журнала: 2025, Номер unknown, С. 106106 - 106106

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
Gene expression analysis and metabolomics of red pitaya fermented with probiotic strains: implications for vitamin D receptor and inflammatory pathways DOI
Juliana Yumi Suzuki, Marcos Edgar Herkenhoff, Jaewon Yoon

и другие.

Food Bioscience, Год журнала: 2025, Номер unknown, С. 106364 - 106364

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Molecular insights of vitamin D receptor SNPs and vitamin D analogs: a novel therapeutic avenue for vitiligo DOI

Sakthi Sasikala Sundaravel,

Beena Briget Kuriakose, Amani Alhazmi

и другие.

Molecular Diversity, Год журнала: 2025, Номер unknown

Опубликована: Март 21, 2025

Язык: Английский

Процитировано

0
Exploring the molecular landscape of osteosarcoma through PTTG family genes using a detailed multi-level methodology DOI Creative Commons
Yulin Lu,

Danjun Wang,

Gengshuo Chen

и другие.

Frontiers in Genetics, Год журнала: 2024, Номер 15

Опубликована: Июль 30, 2024

Osteosarcoma (OS) poses a significant clinical challenge, necessitating comprehensive exploration of its molecular underpinnings.

Язык: Английский

Процитировано

2
Gut Aging: A wane from the normal to repercussion and Gerotherapeutic strategies DOI Creative Commons
Joseph Kofi Abankwah, Ying Wang, Jida Wang

и другие.

Heliyon, Год журнала: 2024, Номер 10(19), С. e37883 - e37883

Опубликована: Сен. 13, 2024

Globally, age-related diseases represent a significant public health concern among the elderly population. In aging, healthy organs and tissues undergo structural functional changes that put aged adults at risk of diseases. Some include cancer, atherosclerosis, brain disorders, muscle atrophy (sarcopenia), gastrointestinal (GIT) etc. organs, decline in stem cell function is starting point many conditions extremely important GIT disorder development. Many studies have established aging affects cells their surrounding supportive niche components. Although there advancement treating intestinal rising population coupled with higher occurrence chronic gut ailments necessitates more effective therapeutic approaches to preserve health. Notable strategies such as Western medicine, traditional Chinese other health-promotion interventions been reported several hold promise mitigating disorders. This review highlights findings across various facets focus on aging-associated components, thus deviation from normal repercussion, well essential mitigate aging.

Язык: Английский

Процитировано

1
Gut Aging: A Wane from the Normal to Repercussion and Gerotherapeutic Strategies DOI
Joseph Kofi Abankwah, Ying Wang, Jida Wang

и другие.

Опубликована: Янв. 1, 2024

Язык: Английский

Процитировано

0
Influence of saponin tauroside Sx1 on lifespan and expression of vitamin D receptors in the liver tissue of mice with influenza infection DOI Creative Commons
Tatiana Sataieva, Veronika Yu. Maligina, Tatiana P. Makalish

и другие.

Drug development & registration, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 8, 2024

Introduction. Respiratory infections, including influenza, are often accompanied by hepatitis in humans which pathogenesis is not fully understood. According to the available datan D deficiency presumably a risk factor occurrence of acute respiratory viral infections due its modulation immune response. Recent studies indicate that several plant compounds can interact with vitamin receptors (VDRs) and modulate activity VDRs. The biologically active components saponins have found widespread use clinical practice their wide range biological pharmacological effects mechanisms still largely unclear. Aim. To study effect oral administration saponin tauroside Sx1, obtained from Crimean ivy, on life expectancy activation liver mice during experimental infection varying severity. Materials methods. 11 subgroups were formed male BALB/c mice, used experiment depending infectious dose influenza virus, 5 LD 50 virus or 10 respectively, control. Saponin Sx1 was as corrector. Immunohistochemical carried out automatically BOND-MAX immunohistainer (Leica, Germany). Primary rabbit polyclonal antibodies receptor used. Results discussion. Due at 200 μg/mouse/day increases average animals receiving 4.6 days. Reducing IV also changed onset death 2 days both groups. With different doses 10th day subgroups, expression changes without correction. In subgroup 2V, number total positive cells lower than control group. Moreover, 2Vir subgroup, VDR significantly higher Conclusion. µg/mouse/day has fairly pronounced antiviral A/H1N1 manifested an increase (for days) decrease mortality rate severe infection, compared group, where 100 % observed 14th experiment. introduction 4th all reduces intensively express VDR.

Язык: Английский

Процитировано

0