European Journal of Pharmacology, Год журнала: 2024, Номер 982, С. 176946 - 176946
Опубликована: Авг. 27, 2024
Язык: Английский
Journal of Biotechnology, Год журнала: 2024, Номер 392, С. 78 - 89
Опубликована: Июнь 28, 2024
Язык: Английский
Процитировано
7
Pharmaceutical Development and Technology, Год журнала: 2025, Номер unknown, С. 1 - 18
Опубликована: Янв. 2, 2025
The formation of inclusion complexes between Ginsenoside Rg3 and cyclodextrins represents a promising strategy to enhance the solubility G-Rg3. Nevertheless, molecular mechanisms underlying interaction G-Rg3 have yet be fully elucidated. In this study, we employed combination simulation experimental methodologies identify most effective solubilizing carriers among G-Rg3, β-cyclodextrin (β-CD), 2-hydroxypropyl-β-cyclodextrin (HP-β-CD), 2,6-dimethyl-β-cyclodextrin (DM-β-CD). formed with HP-β-CD demonstrates superior stability water compared those β-CD DM-β-CD. preparation process for was optimized through an orthogonal testing approach. optimal conditions were determined mass ratio 1:125, time 2 h, temperature 30 °C. confirmed using DSC, Fourier Transform Infrared FTIR, XRD techniques. vitro tests indicated that 2.9 times greater than Molecular dynamics (MD) simulations provided insights into stabilize their solubility. primary force identified as van der Waals force.
Язык: Английский
Процитировано
0
BioMedical Engineering OnLine, Год журнала: 2024, Номер 23(1)
Опубликована: Дек. 21, 2024
Chemotherapy-induced cardiotoxicity is a significant concern in cancer treatment, as certain chemotherapeutic agents can have adverse effects on the cardiovascular system. This lead to range of cardiac complications, including heart failure, arrhythmias, myocardial dysfunction, pericardial and vascular toxicity. Strategies mitigate chemotherapy-induced may include use cardioprotective (e.g., dexrazoxane), dose adjustments, alternative treatment regimens, implementation preventive measures, such lifestyle modifications management risk factors. Ginsenosides, active compounds found ginseng (Panax ginseng), been studied for their potential context cardiotoxicity. In this review, we investigate effect ginsenosides Ginsenosides shown possess potent antioxidant properties, which help oxidative stress inflammation associated with injury. They modulate expression enzymes reduce production reactive oxygen species, thereby protecting cardiomyocytes from damage. also inhibit apoptosis (programmed cell death) cardiomyocytes, key mechanism underlying Modulation ion channels, improvement lipid profiles, anti-platelet anti-thrombotic effects, promotion angiogenesis neovascularization are another important mechanisms behind health. improve various parameters function, ejection fraction, fractional shortening, output, animal models The observed preclinical studies using agents, doxorubicin, cisplatin, 5-fluorouracil. However, more clinical needed fully elucidate therapeutic preventing managing patients.
Язык: Английский
Процитировано
2
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
0
Rejuvenation Research, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 6, 2024
The aim of this study is to elucidate the pharmacological mechanism underlying effects Ginseng Radix et Rhizoma (ginseng) in heart failure (HF), providing a theoretical foundation for its clinical application. potential ginseng context HF was investigated using systems pharmacology that combined network pharmacology, Gene Expression Omnibus (GEO) analysis, molecular docking, and experimental verification. Network employed identify drug-disease targets. Core gene targets were subsequently subjected enrichment analysis by integrating with GEO. Molecular docking utilized predict binding affinities between identified compounds. Furthermore, therapeutic efficacy validated an isoproterenol (ISO)-induced rat model HF. modulation key signaling pathways confirmed through Western blot analysis. A total 154 treatment GSE71613 revealed PI3K-Akt pathway, reactive oxygen species, oxidative phosphorylation, MAPK signaling, Ras are predominantly associated patients By findings from GEO ginsenoside Rg1 Rb3 as components ginseng, while
Язык: Английский
Процитировано
0
Microbiome, Год журнала: 2024, Номер 12(1)
Опубликована: Дек. 2, 2024
Osteosarcopenia, characterized by the simultaneous loss of bone and muscle mass, is a serious health problem in aging population. This study investigated interplay between host genetics, gut microbiota, musculoskeletal mouse model osteosarcopenia, exploring therapeutic potential microbiota modulation. We examined effects Rg3, phytochemical, on osteosarcopenia its interactions with genetics six founder strains Collaborative Cross (CC) Subsequently, we evaluated Eubacterium nodatum (EN) ventriosum (EV), two microbes identified as significant correlates Rg3-mediated improvement, selected C57BL/6 J (B6) 129S1/SvImJ (129S1) strains. Rg3 treatment altered composition aligned phenotypes, which response varied depending genetics. finding enabled identification genus, mediator effect osteosarcopenia. Oral administration EN EV differentially impacted density, exercise performance, related gene expression strain-specific manner. In 129S1 mice, significantly improved these parameters, effectively reversing osteosarcopenic phenotypes. Mechanistic investigations revealed that were mediated through modulation osteoblast differentiation protein degradation pathways. contrast, did not improve phenotypes B6 although they modulate mitochondrial biogenesis microbial diversity. Our findings underscore complex emphasize need for personalized strategies. exhibit effects, suggesting tailoring interventions to individual genetic backgrounds may be crucial optimizing outcomes.
Язык: Английский
Процитировано
0
Reviews in Cardiovascular Medicine, Год журнала: 2024, Номер 25(12)
Опубликована: Ноя. 29, 2024
Ventricular remodeling in right heart failure is a complex pathological process involving interactions between multiple mechanisms. Overactivation of the neuro-hormonal pathways, activation oxidative stress response, expression cytokines, apoptosis cardiomyocytes, and alterations extracellular matrix (ECM) are among major mechanisms involved development ventricular failure. These remodeling, such as myocardial hypertrophy fibrosis, leading to deterioration systolic diastolic function. A deeper understanding these can help develop more effective therapeutic strategies patients with (RHF) improve patient survival quality life. Despite importance RHF, there limited number studies this field. This article explores in-depth historical current information about specific providing theoretical rationale for recognizing its health disease.
Язык: Английский
Процитировано
0
European Journal of Pharmacology, Год журнала: 2024, Номер 982, С. 176946 - 176946
Опубликована: Авг. 27, 2024
Язык: Английский
Процитировано
0