Evaluating the impact of ecological factors on the quality and habitat distribution of Lonicera japonica Flos using HPLC and the MaxEnt model
Frontiers in Plant Science,
Год журнала:
2024,
Номер
15
Опубликована: Авг. 6, 2024
The
quality
of
traditional
Chinese
medicine
is
based
on
the
content
their
secondary
metabolites,
which
vary
with
habitat
adaptation
and
ecological
factors.
This
study
focuses
Язык: Английский
Neurodegenerative diseases and neuroinflammation-induced apoptosis
Open Life Sciences,
Год журнала:
2025,
Номер
20(1)
Опубликована: Янв. 1, 2025
Abstract
Neuroinflammation
represents
a
critical
pathway
in
the
brain
for
clearance
of
foreign
bodies
and
maintenance
homeostasis.
When
neuroinflammatory
process
is
dysregulate,
such
as
over-activation
microglia,
which
results
excessive
accumulation
free
oxygen
inflammatory
factors
brain,
among
other
factors,
it
can
lead
to
an
imbalance
homeostasis
development
various
diseases.
Recent
research
has
indicated
that
numerous
neurodegenerative
diseases
closely
associated
with
neuroinflammation.
The
pathogenesis
neuroinflammation
intricate,
involving
alterations
genes
proteins,
well
activation
inhibition
signaling
pathways.
Furthermore,
inflammation
result
neuronal
cell
apoptosis,
further
exacerbate
extent
disease.
This
article
presents
summary
recent
studies
on
relationship
between
apoptosis
caused
by
aim
identify
link
two
provide
new
ideas
targets
exploring
pathogenesis,
prevention
treatment
Язык: Английский
The immunomodulatory mechanism of acupuncture treatment for ischemic stroke: research progress, prospects, and future direction
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Май 2, 2024
Ischemic
stroke
(IS)
is
one
of
the
leading
causes
death
and
disability.
Complicated
mechanisms
are
involved
in
pathogenesis
IS.
Immunomodulatory
crucial
to
Acupuncture
a
traditional
non-drug
treatment
that
has
been
extensively
used
treat
The
exploration
neuroimmune
modulation
will
broaden
understanding
underlying
acupuncture
treatment.
This
review
summarizes
immune
response
cells,
cytokines,
organs
after
an
immunomodulatory
on
central
nervous
system
peripheral
immunity,
as
well
factors
influence
effects
treatment,
were
summarized.
We
suggest
prospects
future
directions
for
research
IS
based
current
progress,
we
hope
these
provide
inspiration
researchers.
Additionally,
shown
favorable
outcomes
immune-based
diseases,
generating
new
possible
targets
treatments
diseases.
Язык: Английский
Anti-Neuroinflammatory Effect of Ombuin from Rhamnus erythroxylon Pall. Leaves in LPS-Induced BV-2 Microglia by Targeting Src and Suppressing the PI3K-AKT/NF-κB Signaling Pathway
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(16), С. 8789 - 8789
Опубликована: Авг. 13, 2024
The
leaves
of
Rhamnus
erythroxylon
Pall.
are
widely
used
as
tea
substitutes
in
northwest
China
for
their
fragrant
aroma,
anti-irritability,
and
digestion-enhancing
properties.
Ombuin,
a
main
flavonoid
compound
found
the
leaves,
exhibited
notable
anti-inflammatory
antioxidant
effects.
However,
its
potential
role
treating
neuroinflammatory-related
diseases
remains
unexplored.
Thus,
this
study
aims
to
evaluate
anti-neuroinflammatory
effects
ombuin
explore
underlying
molecular
mechanisms.
According
our
findings,
dramatically
reduced
release
interleukin-6
(IL-6),
tumor
necrosis
factor-α
(TNF-α),
IL-1β,
nitric
oxide
(NO),
reactive
oxygen
species
(ROS)
lipopolysaccharide
(LPS)-stimulated
BV-2
microglia.
Further
analysis,
including
transcriptomics,
network
pharmacology,
docking,
cellular
heat
transfer
assays,
revealed
that
Src
was
direct
target
ombuin.
Western
blot
analysis
showed
effectively
suppressed
phosphorylation
inhibited
downstream
expressions
p-PI3K
p85,
p-AKT1,
p-IKKα/β,
p-IκBα,
nuclear
factor
κB
(NF-κB).
Meanwhile,
repression
significantly
reversed
activity
Our
results
identified
implied
exerted
an
effect
by
inhibiting
suppressing
activation
PI3K-AKT
NF-κB
pathways,
which
might
provide
alternative
therapeutic
strategy
neurodegenerative
diseases.
Язык: Английский
Herbal medicines for SOD1G93A mice of amyotrophic lateral sclerosis: preclinical evidence and possible immunologic mechanism
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Сен. 17, 2024
Currently,
there
is
no
cure
or
effective
treatment
for
Amyotrophic
Lateral
Sclerosis
(ALS).
The
mechanisms
underlying
ALS
remain
unclear,
with
immunological
factors
potentially
playing
a
significant
role.
Adhering
to
the
Preferred
Reporting
Items
Systematic
Reviews
and
Meta-Analysis
(PRISMA),
systematic
review
of
preclinical
studies
was
conducted,
searching
seven
databases
including
PubMed,
covering
literature
from
inception
April
10,
2024.
Methodological
quality
included
assessed
using
CAMARADES,
while
risk
bias
in
evaluated
SYRCLE’s
ROB
tool.
Review
Manager
5.4.1
statistical
software
used
meta-analysis
outcomes.
scoping
followed
Joanna
Briggs
Institute
Guidelines
reporting
this
PRISMA-extension
Scoping
(PRISMA
-ScR)
checklist
explore
Herbal
Medicine
(HM)
treating
ALS.
This
involved
18
total
443
animals.
scored
between
4
8
methodological
3
7
bias,
both
summing
up
10.A
remarkable
effects
HM
mice,
onset
time(Standardized
Mean
Difference(SMD):
1.75,
95%
Confidence
Interval(CI)
(1.14
~
2.36),
Z
=
5.60,
P
<
0.01),
survival
time(SMD
1.42,
CI
(0.79
2.04),
4.44,
stride
length(SMD=1.90,
(1.21
2.59),
5.39,
0.01)
duration
time
(Mean
Difference(MD)=6.79,
[-0.28,
13.87],
Z=1.88,
=0.06),
showing
HM’s
certain
efficiency
mice.
ultimately
35
articles
review.
HMs
may
treat
through
such
as
combating
oxidative
stress,
excitatory
amino
acid
toxicity,
calcium
cytotoxicity,
understanding
exploring
will
bring
hope
patients.
Individual
herbs
their
formulations
within
address
variety
immune
pathways,
safeguarding
blood-brain
barrier,
countering
neuroinflammation,
impeding
complement
system
activation,
mitigating
natural
killer
cell
regulating
T
cell-mediated
pathways.
evidence
supports
utilization
conventional
Growing
indicates
that
delay
neurological
degeneration
by
activating
diverse
signaling
especially
Язык: Английский
NeuroAiDTM-II (MLC901) Promoted Neurogenesis by Activating the PI3K/AKT/GSK-3β Signaling Pathway in Rat Spinal Cord Injury Models
Biomedicines,
Год журнала:
2024,
Номер
12(8), С. 1920 - 1920
Опубликована: Авг. 21, 2024
Traumatic
damage
to
the
spinal
cord
(SCI)
frequently
leads
irreversible
neurological
deficits,
which
may
be
related
apoptotic
neurodegeneration
in
nerve
tissue.
The
MLC901
treatment
possesses
neuroprotective
and
neuroregenerative
activity.
This
study
aimed
explore
regenerative
potential
of
molecular
mechanisms
promoting
neurogenesis
functional
recovery
after
SCI
rats.
A
calibrated
forceps
compression
injury
for
15
s
was
used
induce
rats,
followed
by
an
examination
impacts
on
recovery.
Basso,
Beattie,
Bresnahan
(BBB)
scores
were
utilized
assess
neuronal
recovery;
H&E
immunohistochemistry
(IHC)
staining
also
observe
pathological
changes
lesion
area.
Somatosensory
Evoked
Potentials
(SEPs)
measured
using
Nicolet
Язык: Английский