Rutin Alleviates Zearalenone-Induced Endoplasmic Reticulum Stress and Mitochondrial Pathway Apoptosis in Porcine Endometrial Stromal Cells by Promoting the Expression of Nrf2 DOI Creative Commons

Chuangjiang Chen,

Chenlong Wang, Hui Jiang

и другие.

Toxins, Год журнала: 2024, Номер 17(1), С. 7 - 7

Опубликована: Дек. 26, 2024

Zearalenone (ZEA) is a mycotoxin commonly found in moldy cereals and has range of toxic effects that have seriously affected animal husbandry. Rutin, natural flavonoid with antioxidant activities, been studied for its potential involvement mitigating ZEA-induced apoptosis porcine endometrial stromal cells (ESCs) molecular mechanism, particularly concerning the expression Nrf2. This study investigates pathways by which rutin alleviates ESC apoptosis, focusing on role Experimental data reveal ZEA suppresses Nrf2 nuclear translocation reduces mitochondrial membrane (MMP), leading to oxidative stress, endoplasmic reticulum stress (ERS), pathway-driven apoptosis. Notably, mitigates through activation. These findings highlight as critical factor rutin's protective against offering valuable insights clinical prevention treatment toxicity.

Язык: Английский

Naringenin Protected Against Blood Brain Barrier Breakdown after Ischemic Stroke through GSK-3β/ β-Catenin Pathway DOI
Yanping Yang, Liang Li, Yu Liang

и другие.

Neurochemical Research, Год журнала: 2024, Номер 50(1)

Опубликована: Ноя. 18, 2024

Язык: Английский

Процитировано

1
Icariin alleviates cellular injury induced by cardiac ischemia-reperfusion injury by inhibiting IRE1/JNK-induced ferroptosis DOI

Zanrui Zhong,

Kun Yang, Shilin Tang

и другие.

Biochemical and Biophysical Research Communications, Год журнала: 2024, Номер 733, С. 150716 - 150716

Опубликована: Сен. 19, 2024

Язык: Английский

Процитировано

0
Rutin Alleviates Zearalenone-Induced Endoplasmic Reticulum Stress and Mitochondrial Pathway Apoptosis in Porcine Endometrial Stromal Cells by Promoting the Expression of Nrf2 DOI Creative Commons

Chuangjiang Chen,

Chenlong Wang, Hui Jiang

и другие.

Toxins, Год журнала: 2024, Номер 17(1), С. 7 - 7

Опубликована: Дек. 26, 2024

Zearalenone (ZEA) is a mycotoxin commonly found in moldy cereals and has range of toxic effects that have seriously affected animal husbandry. Rutin, natural flavonoid with antioxidant activities, been studied for its potential involvement mitigating ZEA-induced apoptosis porcine endometrial stromal cells (ESCs) molecular mechanism, particularly concerning the expression Nrf2. This study investigates pathways by which rutin alleviates ESC apoptosis, focusing on role Experimental data reveal ZEA suppresses Nrf2 nuclear translocation reduces mitochondrial membrane (MMP), leading to oxidative stress, endoplasmic reticulum stress (ERS), pathway-driven apoptosis. Notably, mitigates through activation. These findings highlight as critical factor rutin's protective against offering valuable insights clinical prevention treatment toxicity.

Язык: Английский

Процитировано

0